6-(allylamino)-4-amino-2-chloro-1,3,5-triazine | 30355-01-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: 6-(allylamino)-4-amino-2-chloro-1,3,5-triazine
• 英文别名: N²-allyl-6-chloro-[1,3,5]triazine-2,4-diyldiamine；N²-Allyl-6-chlor-[1,3,5]triazin-2,4-diyldiamin；6-chloro-2-N-prop-2-enyl-1,3,5-triazine-2,4-diamine
• CAS: 30355-01-2
• 化学式: C₆H₈ClN₅
• 分子量: 185.616
• InChiKey: DJHBMFMPJKLATN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  76.7
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  6-(allylamino)-4-amino-2-chloro-1,3,5-triazine 在 phosphonium iodide 、 氢碘酸 作用下， 生成 N²-allyl-[1,3,5]triazine-2,4-diyldiamine
  参考文献：
  名称：

  CH261812

  摘要：

  公开号：
• 作为产物：
  描述：

  2-氨基-4,6-二氯-S-三嗪 、 丙烯胺 生成 6-(allylamino)-4-amino-2-chloro-1,3,5-triazine
  参考文献：
  名称：

  Substituted Chlorodiamino-s-triazines¹

  摘要：

  DOI：

  10.1021/ja01191a053

文献信息

• Triazine derivatives and herbicides containing said derivatives
  申请人：IDEMITSU KOSAN COMPANY LIMITED

  公开号：EP0273328A2

  公开（公告）日：1988-07-06

  Novel triazine derivatives represented by the general formula (I): (wherein all the symbols are as defined in the appended claims), and herbicides containing the triazine derivatives of the general formula (I) as effective component. These triazine derivatives can exhibit their herbicidal activity against various types of weeds from annual weeds to perennial weeds while causing no injury against paddy rice plants. Thus the herbicides of the present invention have advantages in that the herbicidal effect is great, the chemical damage is low, and the weed-killing spectral width is broad.

  通式(I)代表的新型三嗪衍生物： (其中所有符号如所附权利要求中所定义），以及含有通式（I）的三嗪衍生物作为有效成分的除草剂。这些三嗪衍生物可对从一年生杂草到多年生杂草等各种类型的杂草发挥除草活性，同时不会对水稻植株造成伤害。因此，本发明的除草剂具有除草效果好、化学伤害低、杀草谱宽等优点。
• New triazine derivatives as potent modulators of multidrug resistance
  作者：Alain Dhainaut、Gilbert Regnier、Ghanem Atassi、Alain Pierre、Stephane Leonce、Laurence Kraus-Berthier、Jean Francois Prost

  DOI：10.1021/jm00091a017

  日期：1992.6

  A series of 70 triazine derivatives have been synthesized and tested for their capacity to modulate multidrug resistance (MDR) in DC-3F/AD and KB-A1 tumor cells in vitro, in comparison with verapamil (VRP), a calcium channel antagonist currently used in therapy as an antihypertensive drug, which also shows MDR modulating activity. Among the 12 selected compounds, 16 (S9788) showed high MDR reversing properties in vitro (300- and 6-fold VRP at 5-mu-M in DC-3F/AD and KB-A1 cells, respectively) and induced a strong accumulation of adriamycin. The relationship between the increase of ADR accumulation and the fold reversal induced by these compounds and their lack of effects on the sensitive DC-3F cells suggest that they act mainly by inhibiting the P-glycoprotein (Pgp) catalyzed efflux of cytotoxic agents, as already described for a majority of MDR modulators. In vivo, in association with the antitumor drug vincristine (0.25 mg/kg), 16 (100 mg/kg) increased the TIC by 39% in mice bearing the resistant tumor cell line P388/VCR. According to these interesting properties, 16 was selected for a clinical development because it was more bioavailable than 34, even though it was less active.
• Triazine derivatives, a process for preparation of the derivatives, and herbicides containing the derivatives as the effective component
  申请人：IDEMITSU KOSAN COMPANY LIMITED

  公开号：EP0216259B1

  公开（公告）日：1990-02-28
• US4740230A
  申请人：——

  公开号：US4740230A

  公开（公告）日：1988-04-26
• US4745064A
  申请人：——

  公开号：US4745064A

  公开（公告）日：1988-05-17