But-2-enedioic acid;1-methyl-4-(3-methylsulfanyl-5,6-dihydrobenzo[b][1]benzothiepin-5-yl)piperazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并硫平类
• 英文名称: But-2-enedioic acid;1-methyl-4-(3-methylsulfanyl-5,6-dihydrobenzo[b][1]benzothiepin-5-yl)piperazine
• 化学式: C24H28N2O4S2
• 分子量: 472.6
• InChiKey: IWDBEHWZGDSFHR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.12
• 重原子数：
  32
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  132
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Modulation of microbiota function by gene therapy of the microbiome to prevent, treat or cure microbiome-associated diseases or disorders
  申请人：Eligo Bioscience

  公开号：US11224621B2

  公开（公告）日：2022-01-18

  The invention encompasses compositions, kits and methods for modifying bacteria, preferably naturally occurring bacteria, in situ. These can be used to treat, prevent or cure microbiome-associated diseases or disorders by modulating the molecules expressed and/or secreted by bacterial populations of the microbiome in a specific manner. The genomic modifications can modify the interactions between part or all of these populations and the host in a way that decreases their deleterious potential on host health. The compositions, kits and methods of the invention do not result in the direct death of these populations or a direct significant inhibition of their growth. The invention further includes methods for screening for genetic modifications in the bacteria, for determining the efficiency of vectors at inducing these genetic mutations, and for determining the effects of these mutations on bacterial growth.

  本发明包括原位修饰细菌（最好是天然存在的细菌）的组合物、试剂盒和方法。通过以特定方式调节微生物组细菌群表达和/或分泌的分子，可用于治疗、预防或治愈与微生物组相关的疾病或失调。基因组修饰可以改变部分或全部这些菌群与宿主之间的相互作用，从而降低它们对宿主健康的潜在危害。本发明的组合物、试剂盒和方法不会导致这些种群直接死亡或直接显著抑制其生长。本发明还包括筛选细菌中的基因修饰、确定载体诱导这些基因突变的效率以及确定这些突变对细菌生长的影响的方法。
• METHODS OF DECREASING DYSBIOSIS AND RESTORING A MICROBIOME
  申请人：Vedanta Biosciences, Inc.

  公开号：EP3836946A1

  公开（公告）日：2021-06-23
• MODULATION OF MICROBIOTA FUNCTION BY GENE THERAPY OF THE MICROBIOME TO PREVENT, TREAT OR CURE MICROBIOME-ASSOCIATED DISEASES OR DISORDERS
  申请人：Eligo Bioscience

  公开号：EP4069840A1

  公开（公告）日：2022-10-12
• Method of Treating Transplant Rejection and Autoimmune Diseases
  申请人：Wisconsin Alumni Research Foundation

  公开号：US20140050694A1

  公开（公告）日：2014-02-20

  A method of treating autoimmune diseases and transplant rejection, comprising the step of treating the autoimmune or transplant patient with an effective amount of SU-5416 is disclosed.
• [EN] METHODS OF DECREASING DYSBIOSIS AND RESTORING A MICROBIOME<br/>[FR] MÉTHODES DE DIMINUTION DE LA DYSBIOSE ET DE RESTAURATION D'UN MICROBIOME
  申请人：VEDANTA BIOSCIENCES INC

  公开号：WO2020037271A1

  公开（公告）日：2020-02-20

  Provided herein are methods for decreasing dysbiosis, restoring the microbiome, and/or increasing recovery of a healthy microbiome ( e.g. following a dysbiosis inducing event), by administering pharmaceutical compositions to a subject. Also provided are methods for protecting the microbiome of a subject and/or colonizing the microbiome of a subject by administering pharmaceutical compositions to the subject.