N-(3-Methyl-piperidyl)-trifluoracetamid | 6442-85-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-(3-Methyl-piperidyl)-trifluoracetamid
• 英文别名: N-Trifluoracetyl-β-pipecolin；3-methyl-1-trifluoroacetyl-piperidine；2,2,2-Trifluoro-1-(3-methylpiperidin-1-yl)ethanone
• CAS: 6442-85-9
• 化学式: C₈H₁₂F₃NO
• 分子量: 195.185
• InChiKey: RFFFANRDPGCDDD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• AZEPINE INHIBITORS OF JANUS KINASES
  申请人：Arvanitis Argyrios G.

  公开号：US20120329782A1

  公开（公告）日：2012-12-27

  The present invention provides compounds that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.

  本发明提供了一种可以调节Janus激酶活性的化合物，这些化合物在治疗与Janus激酶活性相关的疾病方面非常有用，例如免疫相关疾病、皮肤疾病、髓系增生性疾病、癌症和其他疾病。
• MULTIHETEROARYL COMPOUNDS AS INHIBITORS OF H-PGDS AND THEIR USE FOR TREATING PROSTAGLANDIN D2 MEDIATED DISEASES
  申请人：Cayman Chemical Corporation, Incorporated

  公开号：US20150099748A1

  公开（公告）日：2015-04-09

  Multiheteroaryl compounds, their preparation, pharmaceutical compositions comprising these compounds, and their pharmaceutical use in the prevention and treatment of prostaglandin D 2 mediated diseases and conditions that may be modulated by the inhibition of hematopoietic prostaglandin D synthase (H-PGDS).

  多取代杂环芳香化合物，其制备方法，包括这些化合物的制药组合物，以及它们在预防和治疗可能通过抑制造血前列腺素D合酶（H-PGDS）调节的前列腺素D2介导的疾病和状况的制药用途。
• Azepine inhibitors of janus kinases
  申请人：Incyte Corporation

  公开号：EP2270014A1

  公开（公告）日：2011-01-05

  The invention provides compounds that modiste the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.

  本发明提供了可调节 Janus 激酶活性的化合物，可用于治疗与 Janus 激酶活性有关的疾病，例如免疫相关疾病、皮肤病、骨髓增生性疾病、癌症和其他疾病。
• US8450326B2
  申请人：——

  公开号：US8450326B2

  公开（公告）日：2013-05-28
• US8563541B2
  申请人：——

  公开号：US8563541B2

  公开（公告）日：2013-10-22