N,N,3-三甲基-4-哌啶胺 | 396133-23-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: N,N,3-三甲基-4-哌啶胺
• 中文别名: 环丁烷甲酰胺，N- [3-[[5-环丙基-2-[[6-[[(3S)-3-(二甲基氨基)-1-吡咯烷基]甲基] -3-吡啶基]氨基] -4-嘧啶基]氨基]丙基]-
• 英文名称: 4-dimethylamino-3-methylpiperidine
• 英文别名: N,N,3-trimethylpiperidin-4-amine
• CAS: 396133-23-6
• 化学式: C₈H₁₈N₂
• mdl: MFCD13178939
• 分子量: 142.244
• InChiKey: FZVOPHDUSUCYND-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-(oxo-κO)-3-quinoline-carboxylato-κO3)difluoro-Boron 、 N,N,3-三甲基-4-哌啶胺 在 三乙胺 作用下， 以 乙腈 、 乙醇 为溶剂， 反应 22.0h， 以74%的产率得到1-cyclopropyl-6-fluoro-8-methoxy-7-(4-dimethylamino-3-methylpiperidin-1-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
  参考文献：
  名称：

  WCK 1152, WCK 1153: Discovery and structure activity relationship for the treatment of resistant pneumococcal and staphylococcal respiratory infections

  摘要：

  DOI：

  10.1016/j.bmcl.2022.128665
• 作为产物：
  描述：

  1-carbethoxy-4-dimethylamino-3-methylpiperidine 在 乙酸乙酯 、 Sodium sulfate-III 作用下， 以 sodium hydroxide 为溶剂， 反应 48.0h， 以to afford 4-dimethylamino-3-methylpiperidine的产率得到N,N,3-三甲基-4-哌啶胺
  参考文献：
  名称：

  Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments

  摘要：

  本发明涉及新一代三重靶向手性广谱抗菌7-取代哌啶酮羧酸衍生物，其光学异构体、对映异构体或对映体，以及其药学上可接受的盐、水合物、前药、多晶形和伪多晶形，以及其制备方法、组成和用途。

  公开号：

  US07393957B2

文献信息

• Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation,compositions and use as medicaments
  申请人：WOCKHARDT LIMITED

  公开号：US20030216568A1

  公开（公告）日：2003-11-20

  This invention relates to new generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, to their optical isomers, diastereomers or enantiomers, as well as pharmaceutically acceptable salts, hydrates, prodrugs, polymorphs and pseudopolymorphs thereof, to their preparation, to their compositions and to their use.

  本发明涉及新一代三重靶向手性广谱抗菌7-取代哌啶酮羧酸衍生物，以及它们的光学异构体、对映异构体或对映体，以及其药学上可接受的盐、水合物、前药、多晶形和假多晶形，以及它们的制备、组成和用途。
• Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-Quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
  申请人：WOCKHARDT LIMITED

  公开号：US20030096812A1

  公开（公告）日：2003-05-22

  This invention relates to new generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, to their optical isomers, diastereomers or enantiomers, as well as pharmaceutically acceptable salts, hydrates, prodrugs, polymorphs and pseudopolymorphs thereof, to their preparation, to their compositions and to their use.

  本发明涉及新一代三重靶向手性广谱抗微生物7-取代哌啶酮羧酸衍生物，其光学异构体，对映异构体或对映体，以及其药学上可接受的盐，水合物，前药，多晶形和假多晶形，以及其制备，组成和使用。
• Inhibitors of cellular efflux pumps of microbes
  申请人：WOCKHARDT LIMITED

  公开号：US20020177559A1

  公开（公告）日：2002-11-28

  Compounds are described which are efflux pump inhibitors of cellular efflux pumps of microbes. Also described are methods of preparing such compounds, methods of using such efflux pump inhibitor compounds and pharmaceutical compositions which include such compounds.

  描述了一些化合物，它们是微生物细胞外输泵的外输泵抑制剂。还描述了制备这些化合物的方法，使用这些外输泵抑制剂化合物的方法以及包括这些化合物的制药组合物。
• New generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
  申请人：De Souza Noel John

  公开号：US20080214608A1

  公开（公告）日：2008-09-04

  This invention relates to new generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, to their optical isomers, diastereomers or enantiomers, as well as pharmaceutically acceptable salts, hydrates, prodrugs, polymorphs and pseudopolymorphs thereof, to their preparation, to their compositions and to their use.

  本发明涉及新一代三重靶向手性广谱抗微生物7-取代哌啶酮羧酸衍生物，以及它们的光学异构体、对映异构体或对映体，以及药学上可接受的盐、水合物、前药、多晶形和伪多晶形，以及它们的制备、组成和使用。
• INHIBITORS OF CELLULAR EFFLUX PUMPS OF MICROBES
  申请人：Wockhardt Limited

  公开号：EP1305048A2

  公开（公告）日：2003-05-02