(3R,4R)-1-(2-cyanoethanoyl)-4-methylpiperidine | 79005-55-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (3R,4R)-1-(2-cyanoethanoyl)-4-methylpiperidine
• 英文别名: (3S,4S)-1-(2-cyanoethanoyl)-4-methylpiperidine；(3R,4R)-1-(2-cyanoacetyl)-4-methylpiperidine；(3S,4S)-1-(cyanoacetyl)-4-methylpiperidin；1-(2-cyanoacetyl)-4-methylpiperidin；3-(4-Methylpiperidino)-3-oxopropanenitrile；3-(4-methylpiperidin-1-yl)-3-oxopropanenitrile
• CAS: 79005-55-3
• 化学式: C₉H₁₄N₂O
• 分子量: 166.223
• InChiKey: OFLGUADWZSEQEI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  44.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (3R,4R)-1-(2-cyanoethanoyl)-4-methylpiperidine 在 氢氧化钾 作用下， 以 乙醇 为溶剂， 生成 (Z)-3-(2-Methyl-benzofuran-5-ylamino)-2-(4-methyl-piperidine-1-carbonyl)-3-[(S)-2-oxo-1-(2-oxo-2-pyrrolidin-1-yl-ethyl)-azepan-3-ylamino]-acrylonitrile
  参考文献：
  名称：

  Ketene aminal-based lactam derivatives as a novel class of orally active FXa inhibitors

  摘要：

  N,N'-Disubstituted ketene aminals are good bioisosteres of thiourea functional groups. We report the design and synthesis of a novel class of ketene aminal-based lactam derivatives as potent and orally active FXa inhibitors. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.08.107

文献信息

• [EN] DRUG DELIVERY SYSTEM FOR LOCALLY DELIVERING THERAPEUTIC AGENTS AND USES THEREOF<br/>[FR] SYSTÈME D'ADMINISTRATION DE MÉDICAMENT POUR ADMINISTRER LOCALEMENT DES AGENTS THÉRAPEUTIQUES ET UTILISATIONS DE CELUI-CI
  申请人：COVAL BIOPHARMA SHANGHAI CO LTD

  公开号：WO2022012492A1

  公开（公告）日：2022-01-20

  Provided herein are drug delivery systems and methods for locally delivering therapeutic agents, and methods for using such drug delivery systems for the treatment of diseases.

  本文提供了药物输送系统和方法，用于局部输送治疗剂，并提供了使用这种药物输送系统治疗疾病的方法。
• Azepine inhibitors of Janus kinases
  申请人：Arvanitis G. Argyrios

  公开号：US20070149506A1

  公开（公告）日：2007-06-28

  The present invention provides compounds that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.

  本发明提供了可调节Janus激酶活性并且在治疗与Janus激酶活性相关的疾病方面有用的化合物，包括但不限于免疫相关疾病、皮肤疾病、髓细胞增生性疾病、癌症和其他疾病。
• AZEPINE INHIBITORS OF JANUS KINASES
  申请人：Arvanitis Argyrios G.

  公开号：US20120329782A1

  公开（公告）日：2012-12-27

  The present invention provides compounds that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.

  本发明提供了一种可以调节Janus激酶活性的化合物，这些化合物在治疗与Janus激酶活性相关的疾病方面非常有用，例如免疫相关疾病、皮肤疾病、髓系增生性疾病、癌症和其他疾病。
• PYRIMIDO-PYRIDAZINONE COMPOUNDS AND METHODS OF USE THEREOF
  申请人：Asana Biosciences, LLC

  公开号：US20160257691A1

  公开（公告）日：2016-09-08

  The present application provides novel pyrimido-pyridazinone compounds and methods for preparing and using these compounds. These compounds are useful in treating inflammation in patients by administering one or more of the compounds to a patient. In one embodiment, the novel pyrimido-pyridazinone compound is of Formula (I) and R 1 and R 2 are defined herein.

  本申请提供了新颖的嘧啶并吡啶嗪酮化合物以及制备和使用这些化合物的方法。这些化合物通过向患者施用一种或多种化合物来治疗患者的炎症。在一个实施例中，新颖的嘧啶并吡啶嗪酮化合物是公式（I）中的化合物，其中R1和R2在此定义。
• TETRACYCLIC INHIBITORS OF JANUS KINASES
  申请人：Rodgers James D.

  公开号：US20090215766A1

  公开（公告）日：2009-08-27

  The present invention provides compounds that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases and cancer.

  本发明提供了一种可以调节Janus激酶活性的化合物，这些化合物可用于治疗与Janus激酶活性相关的疾病，例如免疫相关疾病和癌症。