2-ethyl-6-(2-thienyl)imidazo<2,1-b>thiazole | 53531-05-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并噻唑类
• 英文名称: 2-ethyl-6-(2-thienyl)imidazo<2,1-b>thiazole
• 英文别名: 2-Ethyl-6-thiophen-2-ylimidazo[2,1-b][1,3]thiazole
• CAS: 53531-05-8
• 化学式: C₁₁H₁₀N₂S₂
• 分子量: 234.346
• InChiKey: MFRKIGWOQRFVEH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  73.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  5-ethyl-2-imino-3-(2-thenoylmethyl)-2,3-dihydrothiazole 以 甲苯 为溶剂， 反应 4.0h， 以1.08 g的产率得到2-ethyl-6-(2-thienyl)imidazo<2,1-b>thiazole
  参考文献：
  名称：

  Meakins, G. Denis; Musk, Sally R. R.; Robertson, Colin A., Journal of the Chemical Society. Perkin transactions I, 1989, # 3, p. 643 - 648

  摘要：

  DOI：

文献信息

• 6-Thienyl and 6-phenylimidazo[2,1-b]thiazoles as inhibitors of mitochondrial NADH dehydrogenase
  作者：A Andreani

  DOI：10.1016/s0223-5234(99)00203-2

  日期：1999.10

  Starting from the potent inhibitory effect of the previously described 2 methyl-6-(2-thienyl)imidazo[2,1-b]thiazol on mitochondrial complex I, we prepared a series of derivatives in order to study the effect of a different substitution at the positions 2, 5 and 6. The replacement of the thienyl group at position 6 with a phenyl group does not modify the biological behaviour of the lead compound, whereas the shift of the methyl group from position 2 to position 5 yields a compound devoid of inhibitory effects. In both the 6-thienyl and 6-phenyl series, the lengthening of the chain at position 2 has provided useful information to outline the structural determinants of the ubiquinone antagonist action in imidazothiazole derivatives. (C) 1999 Editions scientifiques et medicales Elsevier SAS.