4-benzofuroxanaldehyde | 61062-98-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶二唑类
• 英文名称: 4-benzofuroxanaldehyde
• 英文别名: 4-formylbenzofurazan；4-Formylbenzofurazanoxid；1-oxy-benzo[1,2,5]oxadiazole-4-carbaldehyde；1-Oxo-2,1lambda~5~,3-benzoxadiazole-4-carbaldehyde；1-oxido-2,1,3-benzoxadiazol-1-ium-4-carbaldehyde
• CAS: 61062-98-4
• 化学式: C₇H₄N₂O₃
• 分子量: 164.12
• InChiKey: IMUDHCCNKIYKAR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  68.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-benzofuroxanaldehyde 以30%的产率得到
  参考文献：
  名称：

  BALASUBRAHMANYAM S. N.; RADHAKRISHNA A. S.; BOULTON A. J.; KAN-WOON T., J. ORG. CHEM. , 1977, 42, NO 5, 897-901

  摘要：

  DOI：
• 作为产物：
  描述：

  2-叠氮基-3-硝基苯甲醛 以 甲苯 为溶剂， 反应 5.0h， 生成 4-benzofuroxanaldehyde
  参考文献：
  名称：

  Furazans and furazan oxides. 7. Interconversions of anthranils, benzofurazan oxides, and indazoles

  摘要：

  DOI：

  10.1021/jo00425a030

文献信息

• Method and Means Relating to Multiple Herbicide Resistance in Plants
  申请人：Cummins Ian

  公开号：US20100184601A1

  公开（公告）日：2010-07-22

  Methods for overcoming multiple herbicide resistance (MHR) in plants using inhibitors of GST suppression of Formula (I), novel chemical inhibitors of Formula (Ia), compositions comprising compounds of Formula (I), and uses and methods relating thereto.

  使用公式(I)的GST抑制剂、公式(Ia)的新型化学抑制剂、含有公式(I)化合物的组合物以及与之相关的用途和方法，来克服植物中的多重除草剂抗性(MHR)的方法。
• Benzofurazanyl- and benzofuroxanyl-1,4-dihydropyridines: synthesis, structure and calcium entry blocker activity
  作者：AM Gasco、G Ermondi、R Fruttero、A Gasco

  DOI：10.1016/s0223-5234(96)80001-8

  日期：1996.1

  The synthesis, structural characterization and calcium blocking activity of a series of benzofurazanyl-1,4-dihydropyridines (18 and 19) and benzofuroxanyl analogues (20 and 21) are reported. H-1-NMR showed that all the benzofuroxan derivatives exist in solution as tautomeric mixtures. The predominant tautomeric form in solution of the derivative 20 (dimethyl 1,4-dihydro-2,6-dimethyl-4-(4-benzofuroxanyl)-3,5-pyridinedicarboxylate) is also the one preferred in the solid state as shown by X-ray analysis. The conformation in the solid state of the benzofurazanyl analogue is also reported. Calcium entry blocker activity of the dihydropyridine derivatives 18-21 has been evaluated in isolated rabbit basilar artery as relaxation of calcium-induced contractions in high K+-depolarizing solution. All the compounds displayed high potency. The activity of benzofurazan derivatives was not changed by the N-oxidation. The two most active compounds 18 and 20 were as potent as Nifedipine.
• ——
  作者：Claudio Medana、Antonella Di Stilo、Sonja Visentin、Roberta Fruttero、Alberto Gasco、Dario Ghigo、Amalia Bosia

  DOI：10.1023/a:1018974409622

  日期：——

  Purpose. To investigate the effect of benzofusion on NO donor properties and related biological activities of the furoxan system. The biological properties considered were the ability to increase the cytosolic levels of cCMP in C6 cells and vasodilation.Methods. NO donor properties were investigated either in the presence or the absence of cysteine by using the Griess reaction, chemiluminescence, and gas chromatography. Increase of cytosolic cGMP levels were evaluated by radioimmunoassay. Vasodilating activity was assessed on rat aorta strips precontracted with noradrenaline, in the presence and the absence of oxyhemoglobin (HbO(2)) and methylene blue (MB), respectively.Results. Benzofuroxan and its methyl and cyano derivatives were unable to release NO under the experimental conditions. Generally these compounds displayed feeble vasodilating properties and were able to weakly stimulate soluble guanylate cyclase (sGC). By contrast, benzodifuroxan and benzotrifuroxan were able to produce both NO. and its reduced form NO-, the nitroxyl anion. They displayed potent vasodilating properties and were able to increase cytosolic levels of cGMP in a concentration-dependent manner.Conclusions. The simple benzofuroxans considered here are devoid of the capability to release NO, they weakly stimulate sGC as well as manifest feeble vasodilating properties by a mechanism that does not involve a thiol-induced NO production. By contrast, benzodifuroxan and benzotrifuroxan behave as typical NO donor furoxans.
• USE OF BENZOFUROXAN DERIVATIVES IN TREATING ANGINA PECTORIS
  申请人：Torrent Pharmaceuticals Ltd

  公开号：EP1079829A1

  公开（公告）日：2001-03-07
• METHOD AND MEANS RELATING TO MULTIPLE HERBICIDE RESISTANCE IN PLANTS
  申请人：University Of Durham

  公开号：EP2190290A2

  公开（公告）日：2010-06-02