N-heptyl-N'-(2-hydroxy-3-piperidino-propoxy)-urea | 186686-40-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-heptyl-N'-(2-hydroxy-3-piperidino-propoxy)-urea
• 英文别名: N-[2-Hydroxy-3-(1-piperidinyl)propoxy]-N'-heptyl-urea；1-heptyl-3-(2-hydroxy-3-piperidin-1-ylpropoxy)urea
• CAS: 186686-40-8
• 化学式: C₁₆H₃₃N₃O₃
• 分子量: 315.456
• InChiKey: DOOWUNBVULOPKQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  22
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  73.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  O-(2-hydroxy-3-piperidino-propyl)-hydroxylamine 、 异氰酸庚酯 以 氯仿 为溶剂， 生成 N-heptyl-N'-(2-hydroxy-3-piperidino-propoxy)-urea
  参考文献：
  名称：

  Anti-ischaemic hydroxylamine derivatives and pharmaceutical compositions

  摘要：

  本发明提供了一种由通式表示的新型羟胺衍生物：其中：X为O、-NH，或者是一个由通式NR'表示的基团，其中R和R'分别独立地选自烷基、环烷基、苯基烷基、苯基（可选择地取代卤素、卤代烷基、烷基、烷氧基或硝基）和含氮杂环；R^1为H或烷酰基，R^2为H或羟基（可选择地酰化为烷酰基），R^3为由通式-NR^4R^5表示的基团，其中R^4和R^5独立地选自H、烷基，以及由通式-CO-NH-R表示的基团，其中R如上所定义，或者当R^4和R^5结合在一起形成一个5-至7-成员的杂环，该杂环可选择地含有一个额外的氮、氧和硫中选择的杂原子，并且可选择地取代为烷基或苯基烷基。此外，还提供了上述化合物的药学上可接受的酸盐，以及含有这些化合物或它们的酸盐盐作为活性成分的药物组合物。该发明的化合物已被证明具有抗缺血作用。

  公开号：

  US06002002A1

文献信息

• Anti-ischaemic hydroxylamine derivatives and pharmaceutical compositions
  申请人：Biorex Research & Development Co.

  公开号：US06002002A1

  公开（公告）日：1999-12-14

  The present invention provides novel hydroxylamine derivatives represented by the general formula: wherein: X is O, --NH, or a group of formula NR', wherein R and R' are independently selected from alkyl, cycloalkyl, phenylalkyl, phenyl optionally substituted with halo, haloalkyl, alkyl, alkoxy or nitro; and a N-containing heterocyclic ring; R.sup.1 is H or alkanoyl, R.sup.2 is H or hydroxy optionally acylated with alkanoyl, and R.sup.3 is a group of the formula --NR.sup.4 R.sup.5 wherein R.sup.4 and R.sup.5 are independently selected from H, alkyl, and a group of the formula --CO--NH--R wherein R is as defined above, or wherein R.sup.4 and R.sup.5 when taken together form a 5- to 7-membered heterocyclic ring which may optionally contain one additional hetero atom selected from nitrogen, oxygen and sulfur and which is optionally substituted with alkyl or phenylalkyl. Also provided are pharmaceutically acceptable acid addition salts of the compounds defined above, as well as pharmaceutical compositions containing the compounds or their acid addition salts as active ingredients. The compounds of the invention have been shown to have anti-ischemic effects.

  本发明提供了一种由通式表示的新型羟胺衍生物：其中：X为O、-NH，或者是一个由通式NR'表示的基团，其中R和R'分别独立地选自烷基、环烷基、苯基烷基、苯基（可选择地取代卤素、卤代烷基、烷基、烷氧基或硝基）和含氮杂环；R^1为H或烷酰基，R^2为H或羟基（可选择地酰化为烷酰基），R^3为由通式-NR^4R^5表示的基团，其中R^4和R^5独立地选自H、烷基，以及由通式-CO-NH-R表示的基团，其中R如上所定义，或者当R^4和R^5结合在一起形成一个5-至7-成员的杂环，该杂环可选择地含有一个额外的氮、氧和硫中选择的杂原子，并且可选择地取代为烷基或苯基烷基。此外，还提供了上述化合物的药学上可接受的酸盐，以及含有这些化合物或它们的酸盐盐作为活性成分的药物组合物。该发明的化合物已被证明具有抗缺血作用。
• [EN] HYDROXYLAMINE DERIVATIVES USEFUL FOR ENHANCING THE MOLECULAR CHAPERON PRODUCTION AND THE PREPARATION THEREOF<br/>[FR] DERIVES D'HYDROXYLAMINE UTILISES POUR AMELIORER LA PRODUCTION DE CHAPERONS MOLECULAIRES ET LEUR PREPARATION
  申请人：BIOREX KUTATÓ ÉS FEJLESZTÓ RT.

  公开号：WO1997016439A1

  公开（公告）日：1997-05-09

  (EN) A method of increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed to a physiological stress which induces expression of a molecular chaperon by the cell with an effective amount of a certain hydroxylamine derivative to increase the stress. Alternatively, a hydroxylamine derivative can be administrated to a cell before it is exposed to a physiological stress which induces expression of a molecular chaperon by the cell. Preferably, the cell to which a hydroxylamine derivative is administered is a eukaryotic cell. The hydroxylamine derivative corresponds to the formulae (I) or (II). The invention also provides novel hydroxylamine derivatives falling within the scope of the formulae (I) and (II) as well as pharmaceutical and/or cosmetical compositions comprising the said compounds.(FR) Procédé visant à accroître l'expression d'un chaperon moléculaire par une cellule et/ou à intensifier l'activité de celui-ci dans les cellules. Le procédé consiste à traiter une cellule qui est exposée à une tension physiologique induisant l'expression d'un chaperon moléculaire par la cellule avec une quantité efficace d'un certain dérivé d'hydroxylamine afin d'augmenter la tension. Selon une autre variante, un dérivé d'hydroxylamine peut être administré à une cellule avant d'être exposé à une tension physiologique induisant l'expression d'un chaperon moléculaire par la cellule. De préférence, la cellule dans laquelle est administré le dérivé d'hydroxylamine est une cellule eucaryote. Le dérivé d'hydroxylamine correspond aux formules (I) et (II). L'invention se rapporte également à des nouveaux dérivés d'hydroxylamine relevant des formules (I) et (II), ainsi qu'à des compositions pharmaceutiques et/ou cosmétiques comprenant ces composés.

  本发明提供了一种增加细胞分子伴侣表达和/或增强细胞中分子伴侣活性的方法。该方法包括使用一定量的某种羟胺衍生物处理受到诱导细胞分子伴侣表达的生理压力的细胞，以增加压力。或者，在细胞暴露于诱导细胞分子伴侣表达的生理压力之前，可以向细胞中注入羟胺衍生物。最好注入羟胺衍生物的细胞是真核细胞。该羟胺衍生物对应于式（I）或（II）。本发明还提供了在式（I）和（II）范围内的新的羟胺衍生物，以及包含这些化合物的药物和/或化妆品组合物。
• Method of enhancing cellular production of molecular chaperon, hydroxylamine derivatives useful for enhancing the chaperon production and the preparation thereof
  申请人：Biorex Research & Development Co.

  公开号：US20040067940A1

  公开（公告）日：2004-04-08

  A method of increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed to a physiological stress which induces expression of a molecular chaperon by the cell with an effective amount of a certain hydroxylamine derivative to increase the stress. Alternatively, an hydroxylamine derivative can be administrated to a cell before it is exposed to a physiological stress which induces expression of a molecular chaperon by the cell. Preferably, the cell to which an hydroxylamine derivative is administered is an eukaryotic cell. The hydroxylamine derivative corresponds to the formulae (I) or (II). The invention also provides novel hydroxylamine derivatives falling within the scope of the formulae (I) and (II) as well as pharmaceutical and/or cosmetical compositions comprising the said compounds.

  提供了一种通过细胞增加分子伴侣表达和/或增强细胞中分子伴侣活性的方法。该方法包括使用一定量的某种羟胺衍生物处理受到诱导细胞分子伴侣表达的生理应激的细胞，以增加应激。或者，在细胞暴露于诱导其表达分子伴侣的生理应激之前，可以向细胞施用羟胺衍生物。最好，施用羟胺衍生物的细胞是真核细胞。羟胺衍生物对应于式(I)或(II)。该发明还提供了落在式(I)和(II)范围内的新羟胺衍生物，以及包含上述化合物的药物和/或化妆品组合物。
• Method of enhancing cellular production of molecular chaperone, hydroxylamine derivatives useful for enhancing the chaperone production and the preparation thereof
  申请人：CytRx Corporation

  公开号：US07745465B2

  公开（公告）日：2010-06-29

  A method of increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed to a physiological stress which induces expression of a molecular chaperon by the cell with an effective amount of a certain hydroxylamine derivative to increase the stress. Alternatively, an hydroxylamine derivative can be administrated to a cell before it is exposed to a physiological stress which induces expression of a molecular chaperon by the cell. Preferably, the cell to which an hydroxylamine derivative is administered is an eukaryotic cell. The hydroxylamine derivative corresponds to the formulae (I) or (II). The invention also provides novel hydroxylamine derivatives falling within the scope of the formulae (I) and (II) as well as pharmaceutical and/or cosmetical compositions comprising the said compounds.

  提供了一种通过细胞增加分子伴侣的表达和/或增强细胞中分子伴侣活性的方法。该方法包括使用一定量的某种羟胺衍生物处理暴露于诱导细胞分子伴侣表达的生理应激下的细胞，以增加压力。另外，可以在细胞暴露于诱导细胞分子伴侣表达的生理应激之前给细胞施加羟胺衍生物。最好，接受羟胺衍生物处理的细胞是真核细胞。羟胺衍生物对应于公式（I）或（II）。本发明还提供了落在公式（I）和（II）范围内的新型羟胺衍生物，以及包含所述化合物的药物和/或化妆品组合物。
• METHOD OF ENHANCING CELLULAR PRODUCTION OF MOLECULAR CHAPERONE, HYDROXYLAMINE DERIVATIVES USEFUL FOR ENHANCING THE CHAPERONE PRODUCTION AND THE PREPARATION THEREOF
  申请人：Vígh László

  公开号：US20100267711A1

  公开（公告）日：2010-10-21

  A method of increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed to a physiological stress which induces expression of a molecular chaperon by the cell with an effective amount of a certain hydroxylamine derivative to increase the stress. Alternatively, an hydroxylamine derivative can be administrated to a cell before it is exposed to a physiological stress which induces expression of a molecular chaperon by the cell. Preferably, the cell to which an hydroxylamine derivative is administered is an eukaryotic cell. The hydroxylamine derivative corresponds to the formulae (I) or (II). The invention also provides novel hydroxylamine derivatives falling within the scope of the formulae (I) and (II) as well as pharmaceutical and/or cosmetical compositions comprising the said compounds.

  本发明提供了一种通过细胞增加分子伴侣的表达和/或增强细胞中分子伴侣活性的方法。该方法包括使用一定量的某种羟胺衍生物处理受到诱导细胞分子伴侣表达的生理应激的细胞，以增加应激。或者，在细胞暴露于诱导其表达分子伴侣的生理应激之前，可以向细胞中注入羟胺衍生物。最好，接受羟胺衍生物处理的细胞是真核细胞。羟胺衍生物对应于公式（I）或（II）。本发明还提供了落在公式（I）和（II）范围内的新羟胺衍生物，以及包含该化合物的药物和/或化妆品组合物。