2,2,2-trifluoro-1-[(3R)-3-hydroxypiperidin-1-yl]ethanone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 2,2,2-trifluoro-1-[(3R)-3-hydroxypiperidin-1-yl]ethanone
• 化学式: C₇H₁₀F₃NO₂
• 分子量: 197.15
• InChiKey: PBTYRDMHPNDRSR-RXMQYKEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] METHODS FOR TREATING HEPATITIS B INFECTIONS<br/>[FR] MÉTHODES DE TRAITEMENT DES INFECTIONS DE TYPE HÉPATITE B
  申请人：ARBUTUS BIOPHARMA CORP

  公开号：WO2019051257A2

  公开（公告）日：2019-03-14

  Certain embodiments of the invention provide a method for identifying a patient that has a higher likelihood of responding to an HBV antigen inhibitor, such a method comprising detecting a hepatitis B virus (HBV) infected patient's genotype at one or more of the IL28B/A associated SNPs described herein, wherein the relevant genotype(s) described herein are indicative of a patient that has a higher likelihood of responding to an HBV antigen inhibitor as compared to an HBV infected patient having different genotypes at these locations.