5-Methylsulfonylsulfanylpentan-1-amine

• 分子结构分类: 有机化合物 - 有机硫化合物 - 磺酰类
• 英文名称: 5-Methylsulfonylsulfanylpentan-1-amine
• 化学式: C₆H₁₅NO₂S₂
• 分子量: 197.3
• InChiKey: WWKICMZNTINRMO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  93.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Enzyme-linked immunoassay, assay kits and pair-binding compounds
  申请人：THE UPJOHN COMPANY

  公开号：EP0117693A2

  公开（公告）日：1984-09-05

  An immunoassay, for measuring the amount of a ligand present in a medium, uses a luciferase-labelled binding pair member selected from a ligand and a receptor, in which the luciferase is linked to the binding pair member via its reactive sulfhydryl group and is thereby reversibly inactivated. A kit, for use in an immunoassay to determine the presence of a ligand in a medium, which comprises a plurality of containers, a first container containing luciferase-labelled receptor or ligand (a purified version of the ligand to be assayed) and a second container containing receptor which may be immobilised. New compounds have a reactive group which can react to cause reversible inactivation of luciferase and a group which can react with one or more sites on a binding receptor or ligand.

  一种用于测量培养基中配体存在量的免疫测定，使用荧光素酶标记的配对结合体，该结合体选自配体和受体，其中荧光素酶通过其活性巯基与配对结合体相连，从而可逆地失活。 用于免疫测定介质中配体存在的试剂盒，由多个容器组成，第一个容器装有荧光素酶标记的受体或配体（待测配体的纯化版本），第二个容器装有可固定的受体。 新化合物具有可导致荧光素酶可逆失活的反应基团，以及可与结合受体或配体上的一个或多个位点发生反应的基团。
• Ligand/receptor pair-binding compounds
  申请人：THE UPJOHN COMPANY

  公开号：EP0234600A1

  公开（公告）日：1987-09-02

  Novel compounds include the group R₇-SO₂-S-C(R₃)₂-C(R₄)₂-(CH₂)n- Either one such group is bonded to R₆ or one or more such groups are bonded to a ligand or receptor, whereupon R₇ may be replaced by a radical derived by removal of the sulfhydryl group from luciferase. Either R₃ is H, CH₃ or C₂H₅ and R₄ is H, CH₃ or C₂H₅ or -C(R₃)₂-C(R₄)₂ - is C4-6 alkylene or 1,4-phenylene; R₆ is -COOH, -COOsuccinimide, -COCl, -COBr, Cl, Br, SCN, NH₂, CN 4-cyanophenyl, -C(OCH₃)=NH.HCl or -(1,4-phenylene)-C(OCH₃)=NH.HCl; R₇ is C1-6 alkyl, phenyl, fluorophenyl, nitrophenyl, (C1-4 alkyl)phenyl, 2-pyridyl or 4-pyridyl; and n is 0 or an integer of 1 to 15; with the proviso that the compound is not CH₃-SO₂-S-CH₂-CH₂-NH₂ or C₆H₅-SO₂-S-CH₂-CH₂-NH₂.

  新型化合物包括以下基团 R₇-SO₂-S-C(R₃)₂-C(R₄)₂-(CH₂)n- 一个这样的基团与 R₆ 键合，或者一个或多个这样的基团与配体或受体键合，此时 R₇ 可被去掉荧光素酶中的巯基而得到的基团取代。 R₃ 是 H、CH₃ 或 C₂H₅ 和 R₄ 是 H、CH₃ 或 C₂H₅ 或 -C(R₃)₂-C(R₄)₂ - 是 C4-6 亚烷基或 1,4-亚苯基； R₆是-COOH、-COO琥珀酰亚胺、-COCl、-COBr、Cl、Br、SCN、NH₂、CN 4-氰基苯基、-C(OCH₃)=NH.HCl 或-(1,4-苯基)-C(OCH₃)=NH.HCl； R₇ 是 C1-6 烷基、苯基、氟苯基、硝基苯基、(C1-4 烷基)苯基、2-吡啶基或 4-吡啶基；以及 n 是 0 或 1 至 15 的整数； 但该化合物不是 CH₃-SO₂-S-CH₂-CH₂-NH₂ 或 C₆H₅-SO₂-S-CH₂-CH₂-NH₂。
• US4614712A
  申请人：——

  公开号：US4614712A

  公开（公告）日：1986-09-30
• US4879249A
  申请人：——

  公开号：US4879249A

  公开（公告）日：1989-11-07