5-O-methyl 3-O-propan-2-yl 2-(2-aminoethoxymethyl)-4-(2,1,3-benzoxadiazol-4-yl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶二唑类
• 英文名称: 5-O-methyl 3-O-propan-2-yl 2-(2-aminoethoxymethyl)-4-(2,1,3-benzoxadiazol-4-yl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
• 化学式: C₂₁H₂₆N₄O₆
• 分子量: 430.5
• InChiKey: KZDURHXEEVEPLY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  31
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  139
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• [EN] COMPOSITIONS OF A CYCLOOXYGENASE-2 SELECTIVE INHIBITOR AND A CALCIUM MODULATING AGENT FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DAMAGE<br/>[FR] COMPOSITIONS RENFERMANT UN INHIBITEUR SELECTIF DE CYCLO-OXYGENASE-2 ET UN AGENT MODULATEUR DE CALCIUM POUR LE TRAITEMENT DE DOMMAGES AU SYSTEME NERVEUX CENTRAL
  申请人：PHARMACIA CORP

  公开号：WO2004093816A2

  公开（公告）日：2004-11-04

  The present invention provides compositions and methods for the treatment of central nervous system damage in a subject. More particularly, the invention provides a combination therapy for the treatment of a vaso-occlusive event, such as a stroke, comprising the administration to a subject of a calcium modulating agent and a cyclooxygenase-2 selective inhibitor.