2-Ethyl-s-triazolo<1,5-a>pyridin | 4931-16-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三唑并吡啶类
• 英文名称: 2-Ethyl-s-triazolo<1,5-a>pyridin
• 英文别名: 2-Ethyl(1,2,4)triazolo(1,5-a)pyridine；2-ethyl-[1,2,4]triazolo[1,5-a]pyridine
• CAS: 4931-16-2
• 化学式: C₈H₉N₃
• 分子量: 147.18
• InChiKey: OIWHGYGUHGWJOI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  30.2
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• QUINUCLIDINE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS
  申请人：Cook, II James H.

  公开号：US20090270405A1

  公开（公告）日：2009-10-29

  The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic α7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.

  该披露提供了公式I的化合物，包括它们的盐，以及使用这些化合物的组合物和方法。这些化合物是烟碱性α7受体的配体，可能对治疗中枢神经系统的各种疾病，特别是情感和神经退行性疾病，有用。
• Quinuclidine Compounds as Alpha-7 Nicotinic Acetylcholine Receptor Ligands
  申请人：Cook, II James H.

  公开号：US20120035178A1

  公开（公告）日：2012-02-09

  The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic α7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.

  该披露提供了I式化合物，包括它们的盐，以及使用这些化合物的组合物和方法。这些化合物是尼古丁酸α7受体的配体，可以用于治疗各种中枢神经系统的疾病，特别是情感和神经退行性疾病。
• DIPEPTIDE ANALOGS AS COAGULATION FACTOR INHIBITORS
  申请人：Pinto Donald J.P.

  公开号：US20100173899A1

  公开（公告）日：2010-07-08

  Disclosed are novel dipeptide analogs compounds of Formula (I), (II) or (III): or a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a solvate, or a prodrug thereof, which are inhibitors of factor XIa and/or plasma kallikrein, compositions containing them, and methods of using them, for example, for the treatment or prophylaxis of thrombotic diseases.

  本发明涉及化合物的新型二肽类似物，其化学式为(I)、(II)或(III)：或其立体异构体、互变异构体、药学上可接受的盐、溶剂化物或前药，其为血凝酶因子XIa和/或血浆卡利肌酶的抑制剂，含有它们的组合物以及使用它们的方法，例如用于治疗或预防血栓性疾病。
• IMIDAZOTRIAZINONE COMPOUNDS
  申请人：FORUM Pharmaceuticals

  公开号：US20140330014A1

  公开（公告）日：2014-11-06

  The present invention provides imidazotriazinone compounds which are inhibitors of phosphodiesterase 9. The present invention further provides processes, pharmaceutical compositions, pharmaceutical preparations and pharmaceutical use of the compounds in the treatment of PDE9 associated diseases or disorders in mammals, including humans.

  本发明提供了咪唑三嗪酮化合物，它们是磷酸二酯酶9的抑制剂。本发明还提供了制备该化合物的方法，以及在哺乳动物（包括人类）治疗PDE9相关疾病或障碍的制药组合物、制药制剂和制药用途。
• Imidazotriazinone Compounds
  申请人：FORUM Pharmaceuticals, Inc.

  公开号：US20150191476A1

  公开（公告）日：2015-07-09

  The present invention provides imidazotriazinone compounds which are inhibitors of phosphodiesterase 9 and pharmaceutically acceptable salt thereof. The present invention further provides processes, pharmaceutical compositions, pharmaceutical preparations and pharmaceutical use of the compounds in the treatment of PDE9 associated diseases or disorders in mammals, including humans.

  本发明提供了咪唑三嗪酮类化合物及其医药上可接受的盐，这些化合物是磷酸二酯酶9的抑制剂。本发明还提供了制备该化合物的方法、药物组合物、药物制剂以及在哺乳动物，包括人类中治疗PDE9相关疾病或疾病的药物用途。