(3S,6R)-1,6-dimethylpiperidin-3-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (3S,6R)-1,6-dimethylpiperidin-3-amine
• 化学式: C₇H₁₆N₂
• 分子量: 128.22
• InChiKey: LTXJSFOJLSNNLC-RQJHMYQMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] HETEROARYL INHIBITORS OF PAD4<br/>[FR] INHIBITEURS HÉTÉROARYLES DE PAD4
  申请人：PADLOCK THERAPEUTICS INC

  公开号：WO2017147102A1

  公开（公告）日：2017-08-31

  The present invention provides compounds useful as inhibitors of PAD4, compositions thereof, and methods of treating PAD4-related disorders.

  本发明提供了作为PAD4抑制剂有用的化合物，其组成物，以及治疗PAD4相关疾病的方法。
• [EN] HETEROCYCLIC PAD4 INHIBITORS<br/>[FR] INHIBITEURS DE PAD4 HÉTÉROCYCLIQUES
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2021163254A1

  公开（公告）日：2021-08-19

  The disclosure generally relates to substituted heterocyclic compounds of Formula (Ia), which are inhibitors of PAD4, method for preparing these compounds, pharmaceutical compositions comprising these compounds and use of these compounds in the treatment of a disease or a disorder associated with PAD4 enzyme activity.

  该披露通常涉及Formula (Ia)的取代杂环化合物，这些化合物是PAD4的抑制剂，制备这些化合物的方法，包含这些化合物的药物组合物以及使用这些化合物治疗与PAD4酶活性相关的疾病或障碍的方法。
• AZA-BENZIMIDAZOLE INHIBITORS OF PAD4
  申请人：Padlock Therapeutics, Inc.

  公开号：EP3386505B1

  公开（公告）日：2020-09-23
• HETEROCYCLIC SPIRO-COMPOUNDS AS AM2 RECEPTOR INHIBITORS
  申请人：THE UNIVERSITY OF SHEFFIELD

  公开号：US20220023281A1

  公开（公告）日：2022-01-27

  Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts thereof: wherein HET, R 1 , R 2 , R 3 , R 4 , R 5 , L, L 1 , X 1 , X 2 , X 3 and q are as defined herein. The compounds are inhibitors of adrenomedullin receptor subtype 2 (AM 2 ). Also disclosed are the compounds for use in the treatment of diseases modulated AM 2 , including proliferative diseases such as cancer; pharmaceutical compositions comprising the compounds; methods for preparing the compounds; and intermediates useful in the preparation of the compounds.
• US9765093B2
  申请人：——

  公开号：US9765093B2

  公开（公告）日：2017-09-19