2-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-3-methyl-cyclopent-2-enone | 480445-16-7

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: 2-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-3-methyl-cyclopent-2-enone
• 英文别名: 2-[3-[Tert-butyl(dimethyl)silyl]oxypropyl]-3-methylcyclopent-2-en-1-one；2-[3-[tert-butyl(dimethyl)silyl]oxypropyl]-3-methylcyclopent-2-en-1-one
• CAS: 480445-16-7
• 化学式: C₁₅H₂₈O₂Si
• 分子量: 268.472
• InChiKey: CABZXXAUAUKCGD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.47
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-3-methyl-cyclopent-2-enone 在 盐酸 作用下， 以 乙腈 为溶剂， 以85%的产率得到2-(3-Hydroxypropyl)-3-methyl-2-cyclopenten-1-on
  参考文献：
  名称：

  Thermal rearrangements of α-(ω-azidoalkyl) enones

  摘要：

  The thermal rearrangement of alpha-(omega-azidoalkyl) enones has been investigated. A variety of these substrates were synthesized and subjected to thermal rearrangement to investigate the scope and generality of their transformation to bicyclic lactams. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)01077-8
• 作为产物：
  描述：

  2-iodo-3-methyl-2-cyclopentenone 、 C₉H₂₁OSiZn 在 tris(dibenzylideneacetone)dipalladium (0) 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以20%的产率得到2-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-3-methyl-cyclopent-2-enone
  参考文献：
  名称：

  Thermal rearrangements of α-(ω-azidoalkyl) enones

  摘要：

  The thermal rearrangement of alpha-(omega-azidoalkyl) enones has been investigated. A variety of these substrates were synthesized and subjected to thermal rearrangement to investigate the scope and generality of their transformation to bicyclic lactams. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)01077-8

文献信息

• Thermal rearrangements of α-(ω-azidoalkyl) enones
  作者：Gary A. Molander、Christopher T. Bibeau

  DOI：10.1016/s0040-4039(02)01077-8

  日期：2002.7

  The thermal rearrangement of alpha-(omega-azidoalkyl) enones has been investigated. A variety of these substrates were synthesized and subjected to thermal rearrangement to investigate the scope and generality of their transformation to bicyclic lactams. (C) 2002 Elsevier Science Ltd. All rights reserved.