{2-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-(2-hydroxy-ethyl)-carbamic acid 9H-fluoren-9-ylmethyl ester | 241489-71-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: {2-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-(2-hydroxy-ethyl)-carbamic acid 9H-fluoren-9-ylmethyl ester
• 英文别名: 9H-fluoren-9-ylmethyl N-[2-[bis(4-methoxyphenyl)-phenylmethoxy]ethyl]-N-(2-hydroxyethyl)carbamate
• CAS: 241489-71-4
• 化学式: C₄₀H₃₉NO₆
• 分子量: 629.753
• InChiKey: GJTJXZNLVMUUCS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  47
• 可旋转键数：
  14
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  77.5
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  {2-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-(2-hydroxy-ethyl)-carbamic acid 9H-fluoren-9-ylmethyl ester 在 哌啶 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.5h， 以1.6 g的产率得到O-(4,4'-dimethoxytrityl)diethanolamine
  参考文献：
  名称：

  Synthesis of Triple Helix Forming Oligonucleotides with a Phenanthroline Moiety into the 3′-3′ Inversion Site of Polarity

  摘要：

  A protocol for the synthesis of triplex forming oligonucleotides containing a chelating molecule in the 3'-3' inversion site of polarity is reported. A number of 16-mers have been synthesized and UV spectroscopy employed to evaluate the stability of their triple helix complexes with the pertinent double-strand oligonucleotide targets. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2002).

  DOI：

  10.1002/1099-0690(200212)2002:24<4228::aid-ejoc4228>3.0.co;2-n
• 作为产物：
  描述：

  (9H-芴-9-基)甲基 2,5-二氧代吡咯烷-1-羧酸 在 4-二甲氨基吡啶 作用下， 以 吡啶 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 生成 {2-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-(2-hydroxy-ethyl)-carbamic acid 9H-fluoren-9-ylmethyl ester
  参考文献：
  名称：

  Synthesis of Triple Helix Forming Oligonucleotides with a Phenanthroline Moiety into the 3′-3′ Inversion Site of Polarity

  摘要：

  A protocol for the synthesis of triplex forming oligonucleotides containing a chelating molecule in the 3'-3' inversion site of polarity is reported. A number of 16-mers have been synthesized and UV spectroscopy employed to evaluate the stability of their triple helix complexes with the pertinent double-strand oligonucleotide targets. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2002).

  DOI：

  10.1002/1099-0690(200212)2002:24<4228::aid-ejoc4228>3.0.co;2-n

文献信息

• ß2GPI GENE EXPRESSION-SUPPRESSING NUCLEIC ACID CONJUGATE
  申请人：Kyowa Hakko Kirin Co., Ltd.

  公开号：US20180193471A1

  公开（公告）日：2018-07-12

  The present invention provides a nucleic acid conjugate comprising: a double-stranded nucleic acid consisting of a sense strand and an antisense strand and comprising a duplex region of at least 11 base pairs; and a ligand part, wherein an oligonucleotide with a strand length of 17 to 30 nucleotides in the antisense strand is complementary to a target β2GPI mRNA sequence, and the 3′ end or 5′ end of the sense strand has a ligand part represented by following formula (I), formula (II), formula (III), formula (IV) or formula (V).
• Synthesis of Triple Helix Forming Oligonucleotides with a Phenanthroline Moiety into the 3′-3′ Inversion Site of Polarity
  作者：Veronica Esposito、Aldo Galeone、Luciano Mayol、Giorgia Oliviero、Antonio Randazzo、Michela Varra

  DOI：10.1002/1099-0690(200212)2002:24<4228::aid-ejoc4228>3.0.co;2-n

  日期：2002.12

  A protocol for the synthesis of triplex forming oligonucleotides containing a chelating molecule in the 3'-3' inversion site of polarity is reported. A number of 16-mers have been synthesized and UV spectroscopy employed to evaluate the stability of their triple helix complexes with the pertinent double-strand oligonucleotide targets. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2002).