Disodium;sulfanide

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 碱金属有机物
• 英文名称: Disodium;sulfanide
• 化学式: HNa2S+
• 分子量: 79.06
• InChiKey: VDQVEACBQKUUSU-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -6.26
• 重原子数：
  3
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  1
• 氢给体数：
  1
• 氢受体数：
  1

ADMET

代谢

硫化氢或任何挥发性硫代谢物在小鼠呼出的气体中都没有发现，即使它们被给予了高达LD50的硫化钠IP剂量。检测系统对给定剂量中不到0.1%的硫是敏感的。

NEITHER H2S2 NOR ANY VOLATILE SULFUR METABOLITES WERE FOUND IN EXPIRED BREATH OF MICE GIVEN SODIUM SULFIDE IP IN DOSES UP TO LD50. DETECTION SYSTEM WAS SENSITIVE TO LESS THAN 0.1% OF SULFUR IN GIVEN DOSES.

来源:Hazardous Substances Data Bank (HSDB)

代谢

硫酸盐...溶于水的硫化物会迅速且完全地在体液中水解... /硫化物/

SODIUM...SOL SULFIDES ARE PROMPTLY & COMPLETELY HYDROLYZED IN BODY FLUIDS... /SULFIDE/

来源:Hazardous Substances Data Bank (HSDB)

代谢

含有钠(35)S-硫化物的肝素化大鼠血液通过孤立的大鼠肺、肾脏或肝脏进行灌注。硫化物氧化的速率和程度因器官而异。在孤立灌注的肺系统中，(35)S-硫化物缓慢氧化为(35)S-硫代硫酸盐；只能检测到少量的(35)S-硫酸盐，可能是由于缺乏硫化物氧化酶。在孤立灌注的肾脏系统中，(35)S-硫化物氧化为(35)S-硫酸盐，(35)S-硫代硫酸盐可能是中间产物。在肝脏灌注实验中，(35)S-硫化物迅速且几乎专门氧化为(35)S-硫酸盐。加入未标记的硫代硫酸盐抑制了(35)S-硫酸盐的形成，并导致孤立肝脏释放(35)S-硫代硫酸盐。硫代硫酸盐是硫化物氧化为硫酸盐的中间产物。大鼠肝脏线粒体中存在一种机制，可以迅速将硫化物氧化为硫代硫酸盐，在谷胱甘肽的存在下，硫代硫酸盐被氧化为硫酸盐。

Heparinized rat blood containing sodium (35)S-sulfide was perfused through isolated rat lungs, kidney or liver. The rate and extent of sulfide oxidation varied from one organ to another. In the isolated perfused lung system, (35)S-sulfide was oxidized slowly to (35)S-thiosulfate; only small amounts of (35)S-sulfate were detectable, possibly due to the absence of sulfide oxidase. In the isolated perfused kidney system, (35)S-sulfide was oxidized to (35)S-sulfate with (35)S-thiosulfate as a possible intermediate. In liver perfusion expt, (35)S-sulfide was oxidized rapidly and almost exclusively to (35)S-sulfate. The addition of unlabeled thiosulfate inhibited the formation of (35)S-sulfate and caused the release of (35)S-thiosulfate from the isolated liver. Thiosulfate is an intermediate in sulfide oxidation to sulfate. A mechanism for the rapid oxidation of sulfide to thiosulfate was present in rat liver mitochondria and, in the presence of glutathione, the thiosulfate was oxiized to sulfate.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 暴露途径

这种物质可以通过吸入、皮肤接触和摄入被身体吸收。

The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

来源:ILO-WHO International Chemical Safety Cards (ICSCs)

毒理性

• 吸入症状

咳嗽。灼热感。呼吸困难。气短。喉咙痛。

Cough. Burning sensation. Laboured breathing. Shortness of breath. Sore throat.

来源:ILO-WHO International Chemical Safety Cards (ICSCs)

毒理性

• 皮肤症状

红斑。疼痛。皮肤灼伤。水疱。

Redness. Pain. Skin burns. Blisters.

来源:ILO-WHO International Chemical Safety Cards (ICSCs)

毒理性

• 眼睛症状

红肿。疼痛。视力模糊。严重深度烧伤。

Redness. Pain. Blurred vision. Severe deep burns.

来源:ILO-WHO International Chemical Safety Cards (ICSCs)

毒理性

• 摄入症状

腹痛。灼热感。休克或昏厥。

Abdominal pain. Burning sensation. Shock or collapse.

来源:ILO-WHO International Chemical Safety Cards (ICSCs)

吸收、分配和排泄

硫化物会迅速从肠道吸收。皮肤吸收的量是否足以引起全身性中毒尚有疑问。/硫化物/

ALKALI SULFIDES ARE RAPIDLY ABSORBED FROM INTESTINE. IT IS DOUBTFUL WHETHER SKIN ABSORBS ENOUGH TO CAUSE SYSTEMIC POISONING. /SULFIDES/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

硫化物自由基部分通过肺和肾脏排出，部分以金属硫化物形式通过肠道排出，还有一部分被氧化成硫酸盐和硫代硫酸盐，并通过肾脏排出。/硫化物/

THE SULFIDE RADICAL IS IN PART EXCRETED BY LUNGS AND KIDNEYS AND AS METALLIC SULFIDES...BY THE BOWEL, AND IN PART OXIDIZED TO SULFATE AND THIOSULFATE AND EXCRETED BY THE KIDNEYS. /SULFIDES/

来源:Hazardous Substances Data Bank (HSDB)