1-[(3S)-1-methylpiperidin-3-yl]propan-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-[(3S)-1-methylpiperidin-3-yl]propan-2-one
• 化学式: C₉H₁₇NO
• 分子量: 155.24
• InChiKey: FCSIGUJMODLKOE-VIFPVBQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• INHIBITORS OF TRANSGLUTAMINASES
  申请人：Zedira GmbH

  公开号：EP3342779A1

  公开（公告）日：2018-07-04

  The invention relates to the compound of general formula (I) as novel inhibitors of transglutaminases, to methods for producing the inventive compounds, to pharmaceutical compositions containing said inventive compounds and to their use for the prophylaxis and treatment of diseases associated with transglutaminases.

  这项发明涉及通式（I）的化合物作为新型转谷氨酰胺酶抑制剂，以及生产这些创新化合物的方法，含有这些创新化合物的药物组合物，以及它们用于预防和治疗与转谷氨酰胺酶相关疾病的用途。
• [EN] INHIBITORS OF BLOOD COAGULATION FACTOR XIII<br/>[FR] INHIBITEURS DU FACTEUR XIII DE COAGULATION DU SANG
  申请人：ZEDIRA GMBH

  公开号：WO2019202052A1

  公开（公告）日：2019-10-24

  The invention relates to a compound of general formula (I) as novel inhibitor of blood coagulation factor XIII, methods for synthesis thereof and to use thereof for the prophylaxis or treatment of diseases associated with blood coagulation factor XIII.

  该发明涉及一种一般式（I）化合物，作为新型抑制血凝因子XIII的抑制剂，其合成方法以及用于预防或治疗与血凝因子XIII相关疾病的用途。
• SELECTIVE TMPRSS2 INHIBITORS AND MEDICAL USE THEREOF
  申请人：Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

  公开号：EP3925667A1

  公开（公告）日：2021-12-22

  The invention relates to the compound of general formula (I) as novel inhibitors of TMPRSS2 and their use for the prophylaxis and treatment of influenza virus infection or coronavirus infection, in particular, SARS-CoV2 (COVID-19) infection.

  该发明涉及一种一般式（I）的化合物，作为TMPRSS2的新型抑制剂，用于预防和治疗流感病毒感染或冠状病毒感染，特别是SARS-CoV2（COVID-19）感染。
• [EN] INHIBITORS OF TRANSGLUTAMINASES<br/>[FR] INHIBITEURS DE TRANSGLUTAMINASES
  申请人：ZEDIRA GMBH

  公开号：WO2018122419A1

  公开（公告）日：2018-07-05

  The invention relates to the compound of general formula (I) as novel inhibitors of transglutaminases, to methods for producing the inventive compounds, to pharmaceutical compositions containing said inventive compounds and to their use for the prophylaxis and treatment of diseases associated with transglutaminases.
• [EN] INHIBITORS OF BLOOD COAGULATION FACTOR XIII<br/>[FR] INHIBITEURS DU FACTEUR XIII DE COAGULATION SANGUINE
  申请人：ZEDIRA GMBH

  公开号：WO2019201432A1

  公开（公告）日：2019-10-24

  The invention relates to a compound of general formula (I) as novel inhibitor ofblood coagulation factor XIII, methods for synthesisthereofand to use thereof for the prophylaxis ortreatment of diseases associated with blood coagulation factor XIII.