Trans-1,2-dimethylpiperidin-4-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: Trans-1,2-dimethylpiperidin-4-amine
• 英文别名: (2R,4S)-1,2-dimethylpiperidin-4-amine
• 化学式: C₇H₁₆N₂
• 分子量: 128.22
• InChiKey: BVVHNDKLDKPYCI-RQJHMYQMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] PROTEIN TYROSINE PHOSPHATASE INHIBITORS<br/>[FR] INHIBITEURS DE PROTÉINE TYROSINE PHOSPHATASE
  申请人：ARRAY BIOPHARMA INC

  公开号：WO2020081848A1

  公开（公告）日：2020-04-23

  Compounds of Formula la or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative diseases in the view of their ability to inhibit SHP2. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.