(3R)-1-(2-methylpropyl)piperidin-3-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (3R)-1-(2-methylpropyl)piperidin-3-ol
• 化学式: C₉H₁₉NO
• 分子量: 157.25
• InChiKey: RQNTUABQBSMZDQ-SECBINFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Carboxamide derivatives and use thereof
  申请人：Purdue Pharma L.P.

  公开号：US10005768B2

  公开（公告）日：2018-06-26

  The present disclosure provides substituted pyridyl-, pyrimidinyl-, pyrazinyl-, pyridazinyl-, and triazinyl-based carboxamides of Formula I-A: and the pharmaceutically acceptable salts and solvates thereof, wherein Z, HET, R10, and E are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I-A to treat a disorder responsive to the blockade of sodium channels. Compounds of the present disclosure are especially useful for treating pain.

  本公开提供了式 I-A 的取代吡啶基、嘧啶基、吡嗪基、哒嗪基和三嗪基羧酰胺： 及其药学上可接受的盐和溶液，其中 Z、HET、R10 和 E 的定义如说明书所述。本公开还涉及使用式 I-A 的化合物治疗对钠离子通道阻断有反应的疾病。本公开的化合物尤其适用于治疗疼痛。
• Indole derivatives and use thereof
  申请人：Purdue Pharma L.P.

  公开号：US10730866B2

  公开（公告）日：2020-08-04

  The Invention provides indole derivatives of Formula I: and pharmaceutically acceptable salts and solvates thereof, wherein R1e, R1f, A, X, Y, Z, and W4 are defined as set forth in the specification. The Invention also provides the use of compounds of Formula I and the pharmaceutically acceptable salts and solvates thereof to treat pain. In certain embodiments, the Compounds of the Invention are effective in treating a disorder responsive to blockade of one or more sodium channels.

  本发明提供了式 I 的吲哚衍生物：及其药学上可接受的盐和溶液，其中 R1e、R1f、A、X、Y、Z 和 W4 的定义如说明书所述。 本发明还提供了式 I 化合物及其药学上可接受的盐和溶解物治疗疼痛的用途。 在某些实施方案中，本发明的化合物对治疗一种或多种钠通道阻断反应性紊乱有效。
• Isoquinoline derivatives and use thereof
  申请人：Purdue Pharma L.P.

  公开号：US10738026B2

  公开（公告）日：2020-08-11

  The Invention provides compounds of Formula (I) and pharmaceutically acceptable salts, solvates, hydrates, N-oxides, or diastereomers thereof: wherein W1, W2, W3, J1, J2, A, R1, R2, R3, R4, R5, a, and b are defined as set forth in the specification. The Invention also provides uses of the compounds of any one of Formulae (I)-(VIII) and the pharmaceutically acceptable salts, solvates, hydrates, N-oxides, or diastereomers thereof. Compounds of the Invention are useful for treating a disorder responsive to blockade of one or more sodium channels. In certain embodiments, Compounds of the Invention are useful for treating pain.

  本发明提供了式(I)化合物及其药学上可接受的盐、溶液剂、水合物、N-氧化物或非对映异构体：其中W1、W2、W3、J1、J2、A、R1、R2、R3、R4、R5、a和b的定义如说明书所述。本发明还提供了式(I)-(VIII)中任一种化合物及其药学上可接受的盐、溶液剂、水合物、N-氧化物或非对映异构体的用途。本发明的化合物可用于治疗对阻断一种或多种钠通道有反应的疾病。在某些实施方案中，本发明化合物可用于治疗疼痛。
• ISOQUINOLINE DERIVATIVES AND USE THEREOF
  申请人：Purdue Pharma L.P.

  公开号：US20170057942A1

  公开（公告）日：2017-03-02

  The Invention provides compounds of Formula (I) and pharmaceutically acceptable salts, solvates, hydrates, N-oxides, or diastereomers thereof: wherein W 1 , W 2 , W 3 , J 1 , J 2 , A, R 1 , R 2 , R 3 , R 4 , R 5 , a, and b are defined as set forth in the specification. The Invention also provides uses of the compounds of any one of Formulae (I)-(VIII) and the pharmaceutically acceptable salts, solvates, hydrates, N-oxides, or diastereomers thereof. Compounds of the Invention are useful for treating a disorder responsive to blockade of one or more sodium channels. In certain embodiments, Compounds of the Invention are useful for treating pain.
• Carboxamide Derivatives and Use Thereof
  申请人：PURDUE PHARMA L.P.

  公开号：US20170096421A1

  公开（公告）日：2017-04-06

  The present disclosure provides substituted pyridyl-, pyrimidinyl-, pyrazinyl-, pyridazinyl-, and triazinyl-based carboxamides of Formula I-A: and the pharmaceutically acceptable salts and solvates thereof, wherein Z, HET, R 10 , and E are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I-A to treat a disorder responsive to the blockade of sodium channels. Compounds of the present disclosure are especially useful for treating pain.