4-methyl-3-(2-oxopropoxy)-8,9,10,11-tetrahydrocyclohepta[c]chromen-6-one | 578763-29-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 环庚吡喃类
• 英文名称: 4-methyl-3-(2-oxopropoxy)-8,9,10,11-tetrahydrocyclohepta[c]chromen-6-one
• 英文别名: 4-methyl-3-(2-oxopropoxy)-8,9,10,11-tetrahydrocyclohepta[c]chromen-6(7H)-one；4-methyl-3-(2-oxopropoxy)-8,9,10,11-tetrahydro-7H-cyclohepta[c]chromen-6-one
• CAS: 578763-29-8
• 化学式: C₁₈H₂₀O₄
• mdl: MFCD03722216
• 分子量: 300.354
• InChiKey: AKNVPVLDNRMSGG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-methyl-3-(2-oxopropoxy)-8,9,10,11-tetrahydrocyclohepta[c]chromen-6-one 在 sodium hydroxide 作用下， 以 异丙醇 为溶剂， 以83%的产率得到8,11-dimethyl-2,3,4,5-tetrahydrocyclohepta[c]furo[3,2-g]chromen-6-one
  参考文献：
  名称：

  Modified coumarins. 24. Synthesis of cycloheptane-annellated tetracyclic furocoumarins

  摘要：

  以2,3,4,5-四氢环庚[c]呋喃[3,2-g]色烯-6-酮为代表的取代物,这类修饰的补骨脂素类似物在呋喃[3,2-g]色烯-7-酮的5,6位置上稠合了一个环庚烷环,是由3-羟基-8,9,10,11-四氢环庚[c]色烯-6-酮合成得到。

  DOI：

  10.1007/s10600-006-0246-8
• 作为产物：
  描述：

  2-氧代-1-环庚烷甲酸甲酯 在 calcined potash 、 硫酸 作用下， 以 甲醇 、 丙酮 为溶剂， 生成 4-methyl-3-(2-oxopropoxy)-8,9,10,11-tetrahydrocyclohepta[c]chromen-6-one
  参考文献：
  名称：

  Modified coumarins. 24. Synthesis of cycloheptane-annellated tetracyclic furocoumarins

  摘要：

  以2,3,4,5-四氢环庚[c]呋喃[3,2-g]色烯-6-酮为代表的取代物,这类修饰的补骨脂素类似物在呋喃[3,2-g]色烯-7-酮的5,6位置上稠合了一个环庚烷环,是由3-羟基-8,9,10,11-四氢环庚[c]色烯-6-酮合成得到。

  DOI：

  10.1007/s10600-006-0246-8

文献信息

• Microrna modulators and method for identifying and using the same
  申请人：Huang Qihong

  公开号：US20100196357A1

  公开（公告）日：2010-08-05

  The present invention is a method for identifying agents which modulate microRNA activity. The invention involves contacting a cell harboring a microRNA and a microRNA binding sequence, which is operably linked to a nucleic acid molecule encoding a reporter protein, with a test agent and determining whether the test agent increases or decreases the expression of the reporter protein thereby identifying a microRNA modulator. Antagonists identified by this screening assay are provided, as are methods for using the same to inhibit microRNA activity and prevent or treat disease.
• MicroRNA Modulators and Method for Identifying And Using The Same
  申请人：Huang Qihong

  公开号：US20120010177A1

  公开（公告）日：2012-01-12

  The present invention is a method for identifying agents which modulate microRNA activity. The invention involves contacting a cell harboring a microRNA and a microRNA binding sequence, which is operably linked to a nucleic acid molecule encoding a reporter protein, with a test agent and determining whether the test agent increases or decreases the expression of the reporter protein thereby identifying a microRNA modulator. Antagonists identified by this screening assay are provided, as are methods for using the same to inhibit microRNA activity and prevent or treat disease.
• MicroRNA Modulators and Method for Identifying and Using the Same
  申请人：Huang Qihong

  公开号：US20130023498A1

  公开（公告）日：2013-01-24

  The present invention is a method for identifying agents which modulate microRNA activity. The invention involves contacting a cell harboring a microRNA and a microRNA binding sequence, which is operably linked to a nucleic acid molecule encoding a reporter protein, with a test agent and determining whether the test agent increases or decreases the expression of the reporter protein thereby identifying a microRNA modulator. Antagonists identified by this screening assay are provided, as are methods for using the same to inhibit microRNA activity and prevent or treat disease.
• US20140255386A1
  申请人：——

  公开号：US20140255386A1

  公开（公告）日：2014-09-11
• [EN] MICRORNA MODULATORS AND METHOD FOR IDENTIFYING AND USING THE SAME<br/>[FR] MODULATEURS DE MICROARN ET MÉTHODE D'IDENTIFICATION ET D'UTILISATION ASSOCIÉE
  申请人：WISTAR INST

  公开号：WO2013019469A1

  公开（公告）日：2013-02-07

  The present invention is a method for identifying agents which modulate microRNA activity. The invention involves contacting a cell harboring a microRNA and a microRNA binding sequence, which is operably linked to a nucleic acid molecule encoding a reporter protein, with a test agent and determining whether the test agent increases or decreases the expression of the reporter protein thereby identifying a microRNA modulator. Antagonists identified by this screening assay are provided, as are methods for using the same to inhibit microRNA activity and prevent or treat disease.