1-Guanidinium-7-aminoheptane

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 原羧酸衍生物
• 英文名称: 1-Guanidinium-7-aminoheptane
• 英文别名: N"-(7-aminoheptyl)methanetriamine
• 化学式: C₈H₂₂N₄
• 分子量: 174.29
• InChiKey: SKGAVCHIFDRDTK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  12
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  90.1
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• COMPOUNDS WEAKENING SAICAR SYNTHASE ACTIVITY, AND APPLICATIONS
  申请人：Geneheal Biotechnology Co., Ltd.

  公开号：EP3524614A1

  公开（公告）日：2019-08-14

  Provided are compounds reducing SAICAR accumulation, and applications. On the basis of existing protein structure data and small molecule structure data, calculations and analysis are performed using software to screen and obtain compounds capable of effectively interfering with PAICS activity, reducing SAICAR synthesis, and ultimately reducing SCICAR accumulation, in order to achieve the goal of treating or improving ADSL deficiency. A better effect in the treatment or improvement of ADSL deficiency is expected from the joint use of at least two of the described compounds.

  提供了减少 SAICAR 积累的化合物及其应用。在现有蛋白质结构数据和小分子结构数据的基础上，利用软件进行计算和分析，筛选并获得能够有效干扰 PAICS 活性、减少 SAICAR 合成并最终减少 SCICAR 积累的化合物，以达到治疗或改善 ADSL 缺乏症的目的。通过联合使用至少两种所述化合物，有望在治疗或改善 ADSL 缺乏症方面取得更好的效果。
• REGULATED BIOCIRCUIT SYSTEMS
  申请人：Obsidian Therapeutics, Inc.

  公开号：US20190192691A1

  公开（公告）日：2019-06-27

  The present invention provides regulatable biocircuit systems. Such systems provide modular and tunable protein expression systems in support of the discovery and development of therapeutic modalities.
• COMPOUNDS WEAKENING SAICAR SYNTHETASE ACTIVITY AND APPLICATIONS
  申请人：GENEHEAL BIOTECHNOLOGY CO., LTD.

  公开号：US20190209499A1

  公开（公告）日：2019-07-11

  Provided are compounds reducing SAICAR accumulation, and applications. On the basis of existing protein structure data and small molecule structure data, calculations and analysis are performed using software to screen and obtain compounds capable of effectively interfering with PAICS activity, reducing SAICAR synthesis, and ultimately reducing SAICAR accumulation, in order to achieve the goal of treating or improving ADSL deficiency. A better effect in the treatment or improvement of ADSL deficiency is expected from the joint use of at least two of the described compounds.
• METHODS OF DETECTION USING X-RAY FLUORESCENCE
  申请人：Icagen, Inc.

  公开号：US20200278346A1

  公开（公告）日：2020-09-03

  The present invention relates, in part, to methods of using X-ray fluorescence (XRF) spectrometry for analyzing (e.g., measuring) the binding of a soluble target to an insoluble material.