(3E,5E)-3,5-bis[(3,4-dichlorophenyl)methylidene]-1-prop-2-enoylpiperidin-4-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (3E,5E)-3,5-bis[(3,4-dichlorophenyl)methylidene]-1-prop-2-enoylpiperidin-4-one
• 化学式: C₂₂H₁₅Cl₄NO₂
• 分子量: 467.2
• InChiKey: FBZOBWNZGBPYHT-BGPOSVGRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Spiro and cyclic bis-benzylidene proteasome inhibitor for the treatment of cancer, diabetes and neurological disorders
  申请人：UP THERAPEUTICS, INC.

  公开号：US10947199B2

  公开（公告）日：2021-03-16

  Described herein are spiro and cyclic bis-benzylidine proteasome inhibitors, which inhibit the proteasome function through either ubiquitin receptor ADRM1/RPN13 or proteasome DUB enzymes (USP14, UCH37 and RPN11), and which can be used for the treatment of cancers/diabetes/neurological disorders.

  本文描述了螺环和环双苄啶蛋白酶体抑制剂，它们通过泛素受体 ADRM1/RPN13 或蛋白酶体 DUB 酶（USP14、UCH37 和 RPN11）抑制蛋白酶体功能，可用于治疗癌症/糖尿病/神经系统疾病。
• Novel Spiro and Cyclic Bis-Benzylidine Proteasome Inhibitor for the Treatment of Cancer, Diabetes and Neurological Disorders
  申请人：UP THERAPEUTICS, INC.

  公开号：US20210163420A1

  公开（公告）日：2021-06-03

  Described herein are spiro and cyclic bis-benzylidine proteasome inhibitors, which inhibit the proteasome function through either ubiquitin receptor ADRM1/RPN13 or proteasome DUB enzymes (USP14, UCH37 and RPN11), and which can be used for the treatment of cancers/diabetes/neurological disorders.
• [EN] NOVEL SPIRO AND CYCLIC BIS-BENZYLIDINE PROTEASOME INHIBITOR FOR THE TREATMENT OF CANCER, DIABETES AND NEUROLOGICAL DISORDERS<br/>[FR] NOUVEL INHIBITEUR DU PROTÉASOME SPIRO ET CYCLIQUE BIS-BENZYLIDINE POUR LE TRAITEMENT DU CANCER, DU DIABÈTE ET DE TROUBLES NEUROLOGIQUES
  申请人：UP THERAPEUTICS INC

  公开号：WO2018140907A1

  公开（公告）日：2018-08-02

  Described herein are spiro and cyclic bis-benzylidine proteasome inhibitors, which inhibit the proteasome function through either ubiquitin receptor ADRM1/RPN13 or proteasome DUB enzymes (USP14, UCH37 and RPN11), and which can be used for the treatment of cancers/diabetes/neurological disorders.