N-烯丙基六亚甲基亚胺 | 53678-65-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂环庚烷
• 中文名称: N-烯丙基六亚甲基亚胺
• 英文名称: N-allylhexamethyleneimine
• 英文别名: N-Allylperhydroazepine；1-allyl-azepane；1-Allyl-hexahydro-azepin；N-allylhomopiperidine；1-prop-2-enylazepane
• CAS: 53678-65-2
• 化学式: C₉H₁₇N
• 分子量: 139.241
• InChiKey: JZLPQYWRRUCUNJ-UHFFFAOYSA-N

物化性质

• 沸点：
  177.3±9.0 °C(Predicted)
• 密度：
  0.846±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.777
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-烯丙基六亚甲基亚胺 、 2,4-喹唑啉二酮 在 三正丙胺 、 三氯氧磷 作用下， 以 1,4-二氧六环 为溶剂， 反应 1.0h， 以54%的产率得到2-(Azepan-1-yl)-4-chloroquinazoline
  参考文献：
  名称：

  Reaction of quinazoline-2,4(1H,3H)-dione with N-substituted cyclic amines in combination with phosphoryl trichloride

  摘要：

  The reaction of quinazoline-2,4(1H,3H)-dione with N-allyl, N-benzyl and N-methyl cyclic amines in combination with phosphoryl trichloride in the presence of tripropylamine in 1,4-dioxane afforded 4-chloro-2-(cycloalkylamino)quinazolines. In the case of N-substituted pyrrolidines, 4-chloro-2-(N-substituted 4-chlorobutylamino) quinazolines were also obtained.

  DOI：

  10.1039/p19910001279
• 作为产物：
  描述：

  环己亚胺 、 3-溴丙烯 在 苯 作用下， 生成 N-烯丙基六亚甲基亚胺
  参考文献：
  名称：

  Kolesnikow; Michailowskaja, Zhurnal Obshchei Khimii, 1957, vol. 27, p. 458;engl.Ausg.S.517

  摘要：

  DOI：

文献信息

• [EN] N-4-(6- (HETEO) ARYL-PYRIMIDIN-4-YLAMINOPHENYL) -BEZENESULFONAMIDES AS KINASE INHIBITORS<br/>[FR] N-4-(6-(HETERO)ARYLE-PYRIMIDINE-4-YLAMINOPHENYLE)-BEZENESULFONAMIDES EN TANT QU'INHIBITEURS DE KINASE
  申请人：ALTANA PHARMA AG

  公开号：WO2005070900A1

  公开（公告）日：2005-08-04

  Compounds of a certain formula 1 in which R1 and R2 have the meanings indicated in the description are novel kinase inhibitors. Formula (1), in which R1 is phenyl, phenyl substituted by R3 and/or R4, naphthalenyl, naphthalenyl substituted by R5 and/or R6, aryl1, aryl1 substituted by R7 and/or R8, R9, R10 or R11, R2 is phenyl, phenyl substituted by R12 and/or R13, naphthalenyl, naphthalenyl substituted by R14 and/or R15, aryl2, aryl2 substituted by R16 and/or R17 or a radical selected from Formula (2).

  某种化学式1的化合物中，其中R1和R2具有描述中指示的含义，是新型激酶抑制剂。化学式（1）中，R1为苯基，苯基被R3和/或R4取代，萘基，萘基被R5和/或R6取代，芳基1，芳基1被R7和/或R8取代，R9，R10或R11，R2为苯基，苯基被R12和/或R13取代，萘基，萘基被R14和/或R15取代，芳基2，芳基2被R16和/或R17取代或从化学式（2）中选取的基团。
• Synthesis, structure and cytotoxicity of new 2-[(3-aminopropyl)dimethylsilyl]-5-furfural diethylacetals and 2-[(3-aminopropyl)dimethylsilyl]-5-phenylfurans
  作者：Luba Ignatovich、Velta Muravenko、Jana Spura、Jury Popelis、Ilona Domrachova、Irina Shestakova

  DOI：10.1002/aoc.2995

  日期：2013.7

  Novel 2‐[(3‐aminopropyl)dimethylsilyl]‐5‐furfural diethylacetals and 2‐[(3‐aminopropyl)di‐methylsilyl]‐5‐phenylfurans have been synthesized by a hydrosilylation reaction of aliphatic and heterocyclic N‐allylamines in the presence of the Speier's catalyst. The effects of the structure of the amine and nature of organic substituent at the furan ring on the cytotoxicity of the new compounds have been

  新型2-[（（3-氨基丙基）二甲基甲硅烷基] -5-糠醛二乙缩醛和2-[（（3-氨基丙基）二甲基甲硅烷基] -5-苯基呋喃）是通过脂肪族和杂环N-烯丙胺的氢化硅烷化反应合成的Speier的催化剂。研究了胺的结构和呋喃环上有机取代基的性质对新化合物的细胞毒性的影响。版权所有©2013 John Wiley＆Sons，Ltd.
• Polymers containing spirobicyclic ammonium moieties as bile acid sequestrants
  申请人：GelTex Pharmaceuticals, Inc.

  公开号：US06271264B1

  公开（公告）日：2001-08-07

  The present invention relates to a method for sequestering bile acids in a patient and to particular polymers for use in the method. The method comprises administering a therapeutically effective amount of a spirobicyclic ammonium moiety-containing polymer composition to a mammal, such as a human, whereby bile acids are sequestered. The polymers of the invention comprise spirobicyclic ammonium moieties and optionally, further comprise a hydrophobic substituent, a quaternary ammonium-containing substituent or a combination thereof.

  本发明涉及一种在患者中固定胆汁酸的方法，以及用于该方法的特定聚合物。该方法包括向哺乳动物（如人类）施用含有螺环双环铵基团的聚合物组合物的治疗有效量，从而固定胆汁酸。本发明的聚合物包括螺环双环铵基团，可选地还包括疏水取代基、季铵基取代基或两者的组合。
• Synthesis and cytotoxic activity of new 2-[(3-aminopropyl)dimethylsilyl]-5-triethylsilylfurans
  作者：Luba Ignatovich、Velta Muravenko、Irina Shestakova、Ilona Domrachova、Juris Popelis、Edmunds Lukevics

  DOI：10.1002/aoc.1538

  日期：2010.3

  Highly cytotoxic 3‐aminopropyl derivatives of 5‐triethylsilyl‐2‐dimethylsilylfuran (LC501–3 µg ml−1) have been prepared by hydrosilylation of heterocyclic N‐allylamines with corresponding hydrosilane in the presence of Speier's catalyst. The influence of the amine structure on the cytotoxicity has been investigated. Copyright © 2009 John Wiley & Sons, Ltd.

  在Speier催化剂的存在下，通过杂环N-烯丙胺与相应的氢硅烷的氢化硅烷化反应，制得了5-三乙基甲硅烷基-2-二甲基甲硅烷基呋喃具有高度细胞毒性的3-氨基丙基衍生物（LC 50 1–3 µg ml -1）。已经研究了胺结构对细胞毒性的影响。版权所有©2009 John Wiley＆Sons，Ltd.
• ADENYLYL CYCLASE INHIBITORS FOR NEUROPATHIC AND INFLAMMATORY PAIN
  申请人：Purdue Research Foundation

  公开号：US20160272572A1

  公开（公告）日：2016-09-22

  The invention generally relates to adenylyl cyclase inhibitor compounds and methods for treating neuropathic or inflammatory pain by using those compounds.

  这项发明通常涉及腺苷酸环化酶抑制剂化合物及利用这些化合物治疗神经病理性或炎症性疼痛的方法。