2-ethyl-5-methyl-4,5-dihydro-oxazole | 57856-70-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑啉类
• 英文名称: 2-ethyl-5-methyl-4,5-dihydro-oxazole
• 英文别名: 2-ethyl-5-methyl oxazoline；2-ethyl-5-methyl-2-oxazoline；Oxazole, 2-ethyl-4,5-dihydro-5-methyl-；2-ethyl-5-methyl-4,5-dihydro-1,3-oxazole
• CAS: 57856-70-9
• 化学式: C₆H₁₁NO
• 分子量: 113.159
• InChiKey: OIEJUWWUWZFIFA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  21.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-ethyl-5-methyl-4,5-dihydro-oxazole 以80%的产率得到
  参考文献：
  名称：

  MAGUET M.; POIRIER Y.; GUGLIELMETTI R., BULL. SOC. CHIM. FRANCE, 1978, PART 2, NO 11-12, 550-560

  摘要：

  DOI：
• 作为产物：
  描述：

  N-(2-羟丙基)丙酰胺 生成 2-ethyl-5-methyl-4,5-dihydro-oxazole
  参考文献：
  名称：

  Maguet,M. et al., Bulletin de la Societe Chimique de France, 1978, vol. , p. 550 - 560

  摘要：

  DOI：

文献信息

• Process for preparing 2-oxazolines utilizing stannous salts of
  申请人：Robinson Brothers Limited

  公开号：US04673748A1

  公开（公告）日：1987-06-16

  This invention relates to a process for preparing 2-oxazolines which comprises cyclodehydrating a hydroxyalkylamide in the presence of a stannous salt of a carboxylic acid. The 2-oxazolines have a variety of uses such as pharmaceutical intermediates, pharmaceuticals and as stabilizers for resins.

  这项发明涉及一种制备2-噁唑啉的过程，包括在羧酸的锡盐存在下，对羟基烷酰胺进行环脱水反应。2-噁唑啉具有多种用途，如制药中间体、药物和树脂稳定剂。
• Nucleophilic Addition of 4,5-Dihydrooxazole Derivatives to Base Generated <i>o</i>-Quinone Methides: A Four-Component Reaction
  作者：Yuk Fai Wong、Ivan Hernandez、Thomas R. R. Pettus

  DOI：10.1021/acs.joc.2c02614

  日期：2023.2.17

  A novel method for joining four components together in a single pot leading to an assortment of N-amino-benzylated phenols is described. The method involves the addition of different Grignard reagents to various o-OBoc salicylaldehydes in the presence of assorted 4,5-dihydrooxazoles, followed by aqueous workup. Seventeen examples are presented with varied (-R, -R′ -R″, -R‴, -R⁗, and Cn) substituents

  描述了一种将四种成分连接在一个罐中从而产生各种 N-氨基苄化苯酚的新方法。该方法涉及在各种 4,5-二氢恶唑存在下向各种o -OBoc 水杨醛中添加不同的格氏试剂，然后进行水处理。提供了 17 个具有不同（-R、-R' -R″、-R‴、-R⁗ 和 C n）取代基的示例。
• Preparation of 2-oxazolines by cyclodehydration process employing inorganic iron salts as catalysts
  申请人：THE DOW CHEMICAL COMPANY

  公开号：EP0033752A1

  公开（公告）日：1981-08-19

  A cyclodehydration process for preparing 2-oxazolines by reacting in liquid phase (a) an N-(2-hydroxyalkyl)-carboxamide with (b) a small but catalytic amount of an ironcontaining compound that has minimum solubility of at least 100 parts per million in the reaction mixture. The reaction is normally conducted at temperatures of 180°C to 200°C and under reduced pressure. Both 2-H- and 2-substituted-2-oxazolines are prepared by this process. Yields of 83 percent or more are obtained.

  一种用于制备 2-噁唑类化合物的环状脱水工艺，其方法是在液相中使(a)N-(2-羟基烷基)-甲酰胺与(b)少量但具有催化作用的含铁化合物发生反应，该化合物在反应混合物中的溶解度至少为百万分之 100。反应通常在 180°C 至 200°C 的温度和减压条件下进行。2-H- 和 2-取代-2-恶唑啉都是通过这种工艺制备的。产量可达 83% 或更高。
• MAGUET M.; POIRIER Y.; GUGLIELMETTI R., C. R. ACAD. SCI <CHDC-AQ>, 1975, C 281, NO 14, 599-601
  作者：MAGUET M.、 POIRIER Y.、 GUGLIELMETTI R.

  DOI：——

  日期：——
• Complexes of polyoxazolines or polyoxazines with polyhalide anions, their preparation, method and sanitizing agents comprising them
  申请人：THE DOW CHEMICAL COMPANY

  公开号：EP0022148B1

  公开（公告）日：1984-11-07