(2-Hydroxy-ethyl)-dimethyl-{10-[4-(4-octyloxy-phenylazo)-phenoxy]-decyl}-ammonium; bromide | 88774-98-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 偶氮苯
• 英文名称: (2-Hydroxy-ethyl)-dimethyl-{10-[4-(4-octyloxy-phenylazo)-phenoxy]-decyl}-ammonium; bromide
• CAS: 88774-98-5
• 化学式: Br*C₃₄H₅₆N₃O₃
• 分子量: 634.741
• InChiKey: COSOKNJFCJLUFG-KPYQYLATSA-M

反应信息

• 作为反应物：
  描述：

  (2-Hydroxy-ethyl)-dimethyl-{10-[4-(4-octyloxy-phenylazo)-phenoxy]-decyl}-ammonium; bromide 以 水 为溶剂， 生成 (2-Hydroxy-ethyl)-dimethyl-{10-[4-(4-octyloxy-phenylazo)-phenoxy]-decyl}-ammonium; bromide
  参考文献：
  名称：

  Design of Photofunctional Laminated Organized Thin Films: Photochromism of Ammoniumazobenzene Arenecarboxylates Cast on Silica Glass

  摘要：

  Arenecarboxylate counterions, i.e., benzoate (BA) and p-t-butylbenzoate (p-t-BBA), were observed to be effective in facilitating E-to-Z photoisomerizations in cast films of 1:1 ion-pair salts of cationic surfactant azobenzene (C8AzoC10N+). Such an effect of the arenecarboxylate ions in C8AzoC10N+ salts showed a contrast to untreated, as-prepared bromide salts, which exhibited no such activity. A remarkable E-to-Z photoisomerization was observed to take place with the cast films of C8AzoC10N+ salts involving bulky anions, BA (or p-t-BBA); their photochromic behavior corresponded well with the aggregated structures of the 1:1 ion-pair salts. Analyses of the π–A isothermal profiles, XRD, and UV–vis spectroscopic investigations showed that C8AzoC10N+-Br stacked films form densely packed interdigitated monolayers, whereas films of the C8AzoC10N+-salt with BA (or p-t-BBA) were found to form loosely packed monolayers.

  DOI：

  10.1246/bcsj.78.698

文献信息

• CARRIER COMPOSITION FOR NUCLEIC ACID TRANSPORT
  申请人：Otsuka Pharmaceutical Co., Ltd.

  公开号：EP1946761A1

  公开（公告）日：2008-07-23

  An object of the present invention is to provide a nucleic acid delivery carrier composition of low toxicity and high safety, the carrier composition, when used to administer a nucleic acid such as an siRNA into an animal-derived cell or organism, being capable of delivering efficiently the nucleic acids into the cells while protecting it from being degraded; and a nucleic acid deliver composition containing the carrier and a nucleic acid. The carrier composition for delivery of a nucleic acid is prepared by mixing (A) a cationic lipid having a steroid skeleton with (B) a tertiary ammonium salt-type cationic lipid. The nucleic acid delivery composition is prepared by mixing the nucleic acid delivery carrier with a nucleic acid.

  本发明的目的是提供一种毒性低、安全性高的核酸递送载体组合物，该载体组合物用于将 siRNA 等核酸递送到动物源性细胞或生物体中时，能够有效地将核酸递送到细胞中，同时保护核酸不被降解；以及一种含有该载体和核酸的核酸递送组合物。 用于递送核酸的载体组合物是通过将(A)具有类固醇骨架的阳离子脂质与(B)叔铵盐型阳离子脂质混合而制备的。核酸递送组合物是通过将核酸递送载体与核酸混合制备的。
• NUCLEIC ACID COMPLEX AND NUCLEIC ACID DELIVERY COMPOSITION
  申请人：Otsuka Pharmaceutical Co., Ltd.

  公开号：EP2217208B1

  公开（公告）日：2011-08-31
• NUCLEIC ACID COMPLEX AND NUCLEIC ACID-DELIVERING COMPOSITION
  申请人：Takeuchi, Hirofumi

  公开号：EP2405001B1

  公开（公告）日：2015-07-08
• Carrier Composition for Nucleic Acid Transport
  申请人：Toyobuku Hidekazu

  公开号：US20090258923A1

  公开（公告）日：2009-10-15

  An object of the present invention is to provide a nucleic acid delivery carrier composition of low toxicity and high safety, the carrier composition, when used to administer a nucleic acid such as an siRNA into an animal-derived cell or organism, being capable of delivering efficiently the nucleic acids into the cells while protecting it from being degraded; and a nucleic acid deliver composition containing the carrier and a nucleic acid. The carrier composition for delivery of a nucleic acid is prepared by mixing (A) a cationic lipid having a steroid skeleton with (B) a tertiary ammonium salt-type cationic lipid. The nucleic acid delivery composition is prepared by mixing the nucleic acid delivery carrier with a nucleic acid.
• PROMPT NUCLEIC ACID DELIVERY CARRIER COMPOSITION
  申请人：Takeuchi Hirofumi

  公开号：US20100063131A1

  公开（公告）日：2010-03-11

  An object of the present invention is to provide a carrier composition for nucleic acid delivery, which can efficiently deliver a nucleic acid into cells when a nucleic acid such as siRNA is administered to animal-derived cells or animals, and also has low toxicity and high safety, and a composition for nucleic acid delivery containing the carrier composition and nucleic acid. A carrier for nucleic acid delivery is prepared by using (A) a diacylphosphatidylcholine, (B) at least one member selected from the group consisting of cholesterol and derivatives thereof, and (C) an aliphatic primary amine. Also, a composition for nucleic acid delivery is prepared by mixing the carrier for nucleic acid delivery with a nucleic acid.