| 1135619-82-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶唑啉
• CAS: 1135619-82-7
• 化学式: C₂₅H₂₂N₂O₃S
• 分子量: 430.527
• InChiKey: XJOGBERAMJDLRM-UDPYIURASA-N

物化性质

• 沸点：
  653.2±55.0 °C(predicted)
• 密度：
  1.318±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为产物：
  描述：

  1-氨基-3,5-二甲苯 、 (E)-N-(4-morpholinophenyl)-3-(3-((Z)-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-ylidene)methyl)phenyl)acrylamide 以 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  Synthesis of novel 1,4-benzoxazin-3-one derivatives as inhibitors against tyrosine kinases

  摘要：

  We designed and synthesized a novel 1,4-benzoxazin-3-one derivative 4 which would have inhibitory activities against tyrosine kinases. They could be synthesized easily from various carboxylic acids 10 and commercially available amines using TFP resin without purification. In this article, we will report the design and synthesis of a novel 1,4-benzoxazin-3-one chemical library 4 and the inhibitory activities against KDR and ABL which are closely related to chronic diseases such as cancer. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.11.060