Pt(6-mp)(dmso)Cl | 809238-00-4

• 英文名称: Pt(6-mp)(dmso)Cl
• 英文别名: [Pt(6-mercaptopurine(-1H))(dmso)Cl]
• CAS: 809238-00-4
• 化学式: C₇H₉ClN₄OPtS₂
• 分子量: 459.84
• InChiKey: MZPRYLRSAFVGLU-UHFFFAOYSA-L

反应信息

• 作为产物：
  描述：

  dichlorobis(dimethyl sulfoxide)platinum(II) 、 6-巯基嘌呤(一水合物) 以 甲醇 为溶剂， 生成 Pt(6-mp)(dmso)Cl
  参考文献：
  名称：

  Multinuclear NMR spectroscopy and antiproliferative activity in vitro of platinum(II) and palladium(II) complexes with 6-mercaptopurine

  摘要：

  A series of Pd(II) and Pt(II) complexes with 6-mercaptopurine (6-Hmp) of formulae Pd(6-HMP)(2)Cl-2 (1), Pd(6-mp)(2)(.)2H(2)O (2), Pt(6-MP)(2).2H(2)O (3), Pt(6-mp)(dmso)Cl (4) was synthesized and studied by IR, far-IR, H-1, C-13, N-15 NMR. (1) has an ionic character and consists of distinct [Pd(6-Hmp)(2)](2+) cations and uncoordinated Cl- anions, whereas (2,3) are neutral species with central atoms bis-chelated by the deprotonated 6-mp(-) ligands. NMR studies suggest that S and N(7) are the complexation sites, while far-IR spectra indicate the squareplanar geometry of Pd(II) or Pt(II). In (4) the Pt(II) atom is coordinated by one chelating 6-mp(-) anion, S-bonded dmso molecule and a terminal chloride. The antiproliferative activity in vitro of (2-4) was tested against human leukaemia HL-60 cells, being exhibited for (2) at the level ca. six times lower than in case of cisplatin. (C) 2004 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molstruc.2004.07.027