3-乙基-2-[(E,3Z)-3-(3-乙基-1,3-苯并恶唑-2-亚基)丙-1-烯基]-1,3-苯并恶唑-3-鎓碘化物 | 37069-75-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶唑啉
• 中文名称: 3-乙基-2-[(E,3Z)-3-(3-乙基-1,3-苯并恶唑-2-亚基)丙-1-烯基]-1,3-苯并恶唑-3-鎓碘化物
• 英文名称: 3,3'-diethyloxacarbocyanine
• 英文别名: 3,3'-Diaethyloxacarbocyanin；3,3'-Diethylcarbocyanin；3.3'-Diethyloxacarbocyaninkation；1,3-bis-(3-ethyl-benzooxazol-2-yl)-trimethinium；3-ethyl-2-[3-(3-ethyl-3H-benzooxazol-2-ylidene)-propenyl]-benzooxazolium；(2Z)-3-ethyl-2-[3-(3-ethyl-1,3-benzoxazol-3-ium-2-yl)prop-2-enylidene]-1,3-benzoxazole
• CAS: 37069-75-3
• 化学式: C₂₁H₂₁N₂O₂
• 分子量: 333.41
• InChiKey: VZUFSMBGWBLOCB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-乙基-2-[(E,3Z)-3-(3-乙基-1,3-苯并恶唑-2-亚基)丙-1-烯基]-1,3-苯并恶唑-3-鎓碘化物 在 氨 作用下， 生成 4-(3-ethyl-3H-benzoxazol-2-ylidene)-crotonic acid-(N-ethyl-2-hydroxy-anilide)
  参考文献：
  名称：

  Hishiki, Journal of the Scientific Research Institute, Tokyo, 1954, vol. 48, p. 130,140

  摘要：

  DOI：

文献信息

• COMPOSITION, SYNTHESIS, AND USE OF A NEW CLASS OF FLUOROPHORES
  申请人：Basu Partha

  公开号：US20080182337A1

  公开（公告）日：2008-07-31

  A new class of fluorophores is presented. The fluorophores include a conjugated ring system, such as a dithiolone, a pyran, and a pyrazine containing ring system. The structure is designed with the flexibility to have multiple substitution patterns. The fluorophores may be used in applications including, but not limited to, biomarker applications, pH sensors, metal sensors, and as components for molecular electronics.

  提供了一类新的荧光物质。这些荧光物质包括一个共轭环系统，比如二硫醚酮、吡喃和含有吡嗪的环系统。该结构设计具有多种取代模式的灵活性。这些荧光物质可用于生物标记物应用、pH传感器、金属传感器以及作为分子电子学组件等应用。
• MACROPHAGE IDENTIFICATION AGENT, AND IDENTIFICATION METHOD, SORTING METHOD, EVALUATION METHOD, SCREENING METHOD AND KIT USING THE MACROPHAGE IDENTIFIER AGENT
  申请人：CANON KABUSHIKI KAISHA

  公开号：US20160018389A1

  公开（公告）日：2016-01-21

  An object of the present invention is to provide an identification method for a macrophage subtype using an organic compound. Another object of the present invention is to provide a macrophage identification agent containing an organic compound in which a spectral characteristic obtained when the organic compound is added is different depending on a macrophage subtype. Still another object of the present invention is to provide an evaluation method for a macrophage subtype using a macrophage identification agent, an analysis method for correlation between a macrophage subtype and a test substance, a screening method for correlation between a macrophage subtype and a test substance, and a kit. An identification method for a macrophage subtype utilizing that a spectral characteristic obtained with an organic compound added is different depending on a macrophage subtype is provided.

  本发明的一个目的是提供一种利用有机化合物对巨噬细胞亚型进行识别的方法。本发明的另一个目的是提供一种巨噬细胞识别试剂，其中当添加有机化合物时得到的光谱特征取决于巨噬细胞亚型而不同。本发明的另一个目的是提供一种利用巨噬细胞识别试剂进行巨噬细胞亚型评估的方法，一种用于巨噬细胞亚型与测试物之间相关性分析的方法，一种用于巨噬细胞亚型与测试物之间相关性筛选的方法，以及一种试剂盒。提供了一种利用添加有机化合物得到的光谱特征不同取决于巨噬细胞亚型的巨噬细胞亚型识别方法。
• PHOSPHONYLATED FLUORESCENT DYES AND CONJUGATES
  申请人：Lukhtanov Eugeny

  公开号：US20080207887A1

  公开（公告）日：2008-08-28

  Reagents are provided for the introduction of phosphonate groups into fluorescent dyes. Methods are also provided for preparing dye conjugates.

  试剂提供了将膦酸酯基团引入荧光染料中的方法。同时还提供了制备染料偶联物的方法。
• Phosphonate fluorescent dyes and conjugates
  申请人：Lukhtanov Eugeny

  公开号：US20070172832A1

  公开（公告）日：2007-07-26

  Reagents are provided for the introduction of phosphonate groups into fluorescent dyes. Methods are also provided for preparing dye conjugates.

  提供试剂用于将膦酸基团引入荧光染料中。同时还提供了制备染料共轭物的方法。
• Lead sensor and methods of use
  申请人：Basu Partha

  公开号：US20100041158A1

  公开（公告）日：2010-02-18

  A fluorophore that forms a complex with Pb ions is disclosed. The fluorophore/lead complex fluoresces with an intensity greater than complexes formed by the fluorophore with other metals. The fluorophore may be used as a sensor/detector for lead ions in various samples. Methods for detecting and calculating the concentration of lead ions in samples are also disclosed.

  本发明公开了一种与Pb离子形成复合物的荧光物质。荧光物质/铅复合物的荧光强度大于荧光物质与其他金属形成的复合物。该荧光物质可用作各种样品中铅离子的传感器/检测器。本发明还公开了检测和计算样品中铅离子浓度的方法。

表征谱图