3-甲基-2-[3-(3-甲基-3H-苯并恶唑-2-亚基)丙-1-烯基]苯并恶唑鎓碘化物 | 14134-79-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶唑啉
• 中文名称: 3-甲基-2-[3-(3-甲基-3H-苯并恶唑-2-亚基)丙-1-烯基]苯并恶唑鎓碘化物
• 中文别名: 3-甲基-2-[3-(3-甲基-3H-苯并恶唑-2-亚基)丙-1-烯基]苯并恶唑碘化物；3,3-二甲基氧杂甲花青苷碘
• 英文名称: 3,3'-Dimethyloxacarbcyanin Iodid (9)
• 英文别名: 3-methyl-2-(3-(3-methylbenzoxazol-2(3H)-ylidene)prop-1-en-1-yl)benzoxazol-3-ium iodide；1,3-bis-(3-methyl-benzooxazol-2-yl)-trimethinium; iodide；3-methyl-2-[3-(3-methyl-3H-benzooxazol-2-ylidene)-propenyl]-benzooxazolium; iodide；1,3-bis-(3-methyl-benzoxazol-2-yl)-trimethinium ; iodide；3-methyl-2-[3-(3-methyl-3H-benzoxazol-2-ylidene)prop-1-enyl]benzoxazolium iodide；1,3-Bis-(3-methyl-benzoxazol-2-yl)-trimethinium; Jodid；3,3'-dimethyloxacarbocyanine iodide；Oxazolgelb；(2E)-3-methyl-2-[3-(3-methyl-1,3-benzoxazol-3-ium-2-yl)prop-2-enylidene]-1,3-benzoxazole;iodide
• CAS: 14134-79-3
• 化学式: C₁₉H₁₇N₂O₂*I
• 分子量: 432.261
• InChiKey: PXGXZGVGEDLSMW-UHFFFAOYSA-M

物化性质

• 熔点：
  262℃

计算性质

• 辛醇/水分配系数(LogP)：
  0.64
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S26,S36
• 危险类别码：
  R36/37/38

反应信息

• 作为反应物：
  描述：

  3-甲基-2-[3-(3-甲基-3H-苯并恶唑-2-亚基)丙-1-烯基]苯并恶唑鎓碘化物 在 Amberlite IRA-400 (Cl) 作用下， 以 甲醇 为溶剂， 生成 3-methyl-2-(3-(3-methylbenzoxazol-2(3H)-ylidene)prop-1-en-1-yl)benzoxazol-3-ium chloride
  参考文献：
  名称：

  A comparative study of symmetrical and unsymmetrical trimethine cyanine dyes bearing benzoxazolyl and benzothiazolyl groups

  摘要：

  Six symmetrical and unsymmetrical trimethine cyanine dyes bearing benzothiazolyl and benzoxazolyl groups were synthesized. Their linear optical properties were studied. It was found that the variation of hetero atoms play an important role in the spectral properties of the dyes. Sequential replacement of the oxygen atom by the sulfur atom resulted in a change in shade from yellow to purple. In order to understand the relationship between the molecular structures and the spectral properties of these dyes, theoretical calculations were made using the Gaussian programme. Key parameters related to absorption and emission spectra were reported and discussed. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.dyepig.2011.11.001
• 作为产物：
  描述：

  3,3'-dimethyl-2,2'-propanediyl-bis-benzoxazolium; diiodide 在 sodium hydroxide 、 potassium hexacyanoferrate(III) 作用下， 生成 3-甲基-2-[3-(3-甲基-3H-苯并恶唑-2-亚基)丙-1-烯基]苯并恶唑鎓碘化物
  参考文献：
  名称：

  Kiprianow; Uschenko, Zhurnal Obshchei Khimii, 1937, vol. 17, p. 1538,1540

  摘要：

  DOI：

文献信息

• Cellular analysis of body fluids
  申请人：Abbott Laboratories

  公开号：US10774359B2

  公开（公告）日：2020-09-15

  Herein is provided a simple, reliable and accurate method for cellular analysis on hematology analyzers. In various aspects, the methods provide separation and/or differentiation between red blood cells (RBCs) and white blood cells (WBCs) by utilizing a fluorescent dye to selectively stain WBCs such that they emit stronger fluorescence signals. The method provides optimal detection limits on WBCs and RBCs, thereby allowing analysis of samples with sparse cellular concentrations. As few as one reagent may be used to prepare a single dilution for body fluid analysis, in order to simplify the body fluid analysis. Minimal damage to WBCs is attained using the lysis-free approach described in aspects of the disclosure.

  本文提供了一种在血液分析仪上进行细胞分析的简单、可靠和准确的方法。在各个方面，该方法通过利用荧光染料选择性地染色白细胞，使其发出更强的荧光信号，从而分离和/或区分红细胞（RBC）和白细胞（WBC）。该方法可提供白细胞和红细胞的最佳检测限，从而对细胞浓度稀少的样本进行分析。为了简化体液分析，只需使用一种试剂就能配制出用于体液分析的单一稀释液。使用本公开各方面所述的无裂解方法可将对白细胞的损伤降至最低。
• Reagent and process for the identification and counting of biological cells
  申请人：——

  公开号：US20020182623A1

  公开（公告）日：2002-12-05

  The invention relates to a reagent and a process for the identification and counting of biological cells in a sample. This reagent comprises a cell lysing agent selected from at least one detergent in a concentration capable of specifically lysing a given type of cells in the sample, and a stain capable of marking the intracellular nucleic acids of the remaining unlysed cells. Application in particular for the identification and counting of cells using an automated analysis system based on flow cytometry.

  本发明涉及一种用于识别和计数样品中生物细胞的试剂和工艺。这种试剂包括一种细胞裂解剂，选自至少一种洗涤剂，其浓度能够特异性地裂解样品中的特定类型的细胞；还包括一种染色剂，能够标记剩余的未裂解细胞的细胞内核酸。特别适用于使用基于流式细胞仪的自动分析系统对细胞进行识别和计数。
• Ogata, Proceedings of the Imperial Academy (Tokyo), 1933, vol. 9, p. 602,604
  作者：Ogata

  DOI：——

  日期：——
• Koenig; Meier, Journal fur praktische Chemie (Leipzig 1954), 1925, vol. <2> 109, p. 341,342
  作者：Koenig、Meier

  DOI：——

  日期：——
• Ogata, Nippon Kagaku Kaishi/Journal of the Chemical Society of Japan, 1934, vol. 55, p. 394,411
  作者：Ogata

  DOI：——

  日期：——