dibenzo-1,4-dioxin-1,3,6,8-tetraol | 121449-71-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并二恶英
• 英文名称: dibenzo-1,4-dioxin-1,3,6,8-tetraol
• 英文别名: dibenzo[1,4]dioxine-2,4,7,9-tetraol；dibenzodioxine-1,3,6,8-tetraol；Dibenzo-p-dioxin-1,3,6,8-tetrol
• CAS: 121449-71-6
• 化学式: C₁₂H₈O₆
• 分子量: 248.192
• InChiKey: YGRMPMIDAOECSI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  99.4
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-溴-3,5-二甲氧基苯酚 生成 dibenzo-1,4-dioxin-1,3,6,8-tetraol
  参考文献：
  名称：

  FUKUYAMA, YOSHIYASU;KODAMA, MITSUAKI;MIURA, IWAO;KINZYO, ZYUNEI;KIDO, MAS+, CHEM. AND PHARM. BULL., 37,(1989) N, C. 349-353

  摘要：

  DOI：

文献信息

• Structure of an anti-plasmin inhibitor, eckol, isolated from the brown alga Ecklonia kurome OKAMURA and inhibitory activities of its derivatives on plasma plasmin inhibitors.
  作者：Yoshiyasu FUKUYAMA、Mitsuaki KODAMA、Iwao MIURA、Zyunei KINZYO、Masaru KIDO、Hideo MORI、Yasuo NAKAYAMA、Masayuki TAKAHASHI

  DOI：10.1248/cpb.37.349

  日期：——

  Eckol (1), a novel phlorotannin with a dibenzo-1, 4-dioxin skeleton, has been isolated from the brown alga Ecklonia kurome OKAMURA as a potent and specifif and specific anti-plasmin inhibitor. Its structure has been elucidated based on the spectral data, in particular, by means of negative nuclear Overhauser effect (NOE), and finally established as 1-(3, 5-dihydroxyphenoxy)-2, 4, 7, 9-tetrahydroxydibenzo-1, 4-dioxin by X-ray analysis. Some partially methoxylated derivatives of eckol wre prepared by methylation with diazomethane and also by selective demethylation of eckol permethylate (1b) to establish the structural requirements for inhibitory activities on α2-macroglobulin and α2-plasmin inhibitor, the main plasmin inhibitors in plasma.

  Eckol (1)是从褐藻 Ecklonia kurome OKAMURA 中分离出来的一种具有二苯并-1，4-二恶英骨架的新型绿单宁，是一种强效、特异性和专一性的抗浆细胞蛋白抑制剂。根据光谱数据，特别是通过负核奥弗豪泽尔效应（NOE）阐明了其结构，并通过 X 射线分析最终确定其为 1-（3，5-二羟基苯氧基）-2，4，7，9-四羟基二苯并-1，4-二恶英。通过与重氮甲烷的甲基化反应以及过甲酸埃克醇（1b）的选择性去甲基化反应，制备了一些埃克醇的部分甲氧基化衍生物，以确定其对血浆中主要的血浆蛋白酶抑制剂--α2-巨球蛋白和α2-血浆蛋白酶抑制剂的抑制活性的结构要求。
• FUKUYAMA, YOSHIYASU;KODAMA, MITSUAKI;MIURA, IWAO;KINZYO, ZYUNEI;KIDO, MAS+, CHEM. AND PHARM. BULL., 37,(1989) N, C. 349-353
  作者：FUKUYAMA, YOSHIYASU、KODAMA, MITSUAKI、MIURA, IWAO、KINZYO, ZYUNEI、KIDO, MAS+

  DOI：——

  日期：——
• ANTI-VIRAL COMPOUND
  申请人：Byotrol PLC

  公开号：US20220023254A1

  公开（公告）日：2022-01-27

  Phlorotannins with anti-viral properties, in particular those with a molecular mass of from about 1000 g/mol to about 3000 g/mol, are described. The phlorotannins may be obtained or obtainable as an extract from seaweed, and may be used in compositions or extracts as anti-viral agents. Methods for producing the extracts and their use for treating or preventing viral infections and for reducing or controlling a virus on a surface using the phlorotannins are also described.
• [EN] COMPOSITION FOR PREVENTING OR TREATING INFLUENZA, CONTAINING, AS ACTIVE INGREDIENT, ECKLONIA CAVA EXTRACT OR PHLOROTANNIN-BASED COMPOUND ISOLATED THEREFROM<br/>[FR] COMPOSITION POUR LA PRÉVENTION OU LE TRAITEMENT DE LA GRIPPE, CONTENANT, EN TANT QUE SUBSTANCE ACTIVE, UN EXTRAIT D'ECKLONIA CAVA OU UN COMPOSÉ À BASE DE TANNIN ISOLÉ À PARTIR DE CELUI-CI<br/>[KO] 감태 추출물 또는 이로부터 분리한 플로로탄닌계 화합물을 유효성분으로 포함하는 인플루엔자의 예방 또는 치료용 조성물
  申请人：UNIV CHOSUN IACF

  公开号：WO2018088777A1

  公开（公告）日：2018-05-17

  본 발명은 감태(Ecklonia cava) 추출물 또는 이로부터 분리한 플로로탄닌계 화합물을 유효성분으로 포함하는 인플루엔자의 예방 또는 치료용 조성물에 관한 것이다. 감태 추출물 또는 이로부터 분리한 플로로탄닌계 화합물인 디벤조[1,4]디오신-2,4,7,9-테트라올(Dibenzo[1,4]dioxine-2,4,7,9-tetraol)(화합물 1), 디옥시노데히드로에콜(Dioxinodehydroeckol)(화합물 2) 및 6,6'-비에콜(6,6'-bieckol)(화합물 3)이 조류 인플루엔자 바이러스 또는 돼지 인플루엔자 바이러스에 대해 항바이러스 활성을 가지고 있어, 인플루엔자 예방 및 치료용 조성물 개발에 유용하게 이용할 수 있을 것으로 기대된다.