5-[(叔丁氧基)羰基]-5-氮杂螺[3.4]辛烷-2-羧酸 | 1363381-67-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂螺癸烷衍生物
• 中文名称: 5-[(叔丁氧基)羰基]-5-氮杂螺[3.4]辛烷-2-羧酸
• 英文名称: 5-(tert-butoxycarbonyl)-5-azaspiro[3.4]octane-2-carboxylic acid
• 英文别名: 5-[(2-methylpropan-2-yl)oxycarbonyl]-5-azaspiro[3.4]octane-2-carboxylic acid
• CAS: 1363381-67-2
• 化学式: C₁₃H₂₁NO₄
• 分子量: 255.314
• InChiKey: JPRDSXJTSHIDCU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  66.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-[(叔丁氧基)羰基]-5-氮杂螺[3.4]辛烷-2-羧酸 、 N-[7-isopropoxy-2-(4-piperidyl)imidazo[1,2-a]pyridin-6-yl]-6-(trifluoromethyl)pyridine-2-carboxamide 在 N,N-二异丙基乙胺 、 Methanaminium,N-[(dimethylamino)(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methyl-, hexafluorophosphate(1-) 作用下， 以 二甲基亚砜 为溶剂， 生成
  参考文献：
  名称：

  [EN] COMPOUNDS FOR TARGETING DEGRADATION OF IRAK4 PROTEINS
  [FR] COMPOSÉS POUR LE CIBLAGE DE LA DÉGRADATION DE PROTÉINES IRAK4

  摘要：

  This disclosure relates to compounds of Formula (A): Formula (A), or a pharmaceutically acceptable salt thereof, wherein DSM is a degradation signaling moiety that is covalently attached to the linker L, L is a linker that covalently attaches IRAK to DSM; and IRAK is an IRAK4 binding moiety represented by Formula (I) that is covalently attached to linker L; Formula (I) in which all of the variables are as defined in the application. Compounds or pharmaceutically acceptable salts thereof as described herein are capable of activating the selective ubiqitination of IRAK4 proteins via the ubiquitin-proteasome pathways (UPP) and cause degradation of IRAK4 proteins. The present disclosure also provides methods of treating disorders responsive to modulation of IRAK4 activity and/or degradation of IRAK4 with at least one compound described herein.

  公开号：

  WO2023283372A1