1,3,5-Triazine-2,4-diamine, 6-methyl-N-(phenylmethyl)- | 112878-50-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: 1,3,5-Triazine-2,4-diamine, 6-methyl-N-(phenylmethyl)-
• 英文别名: 2-N-benzyl-6-methyl-1,3,5-triazine-2,4-diamine
• CAS: 112878-50-9
• 化学式: C₁₁H₁₃N₅
• 分子量: 215.25
• InChiKey: STZWLZUMSSQFTO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  76.7
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  N-benzyl-4-chloro-6-methyl-1,3,5-triazin-2-amine 、 氨 以93%的产率得到
  参考文献：
  名称：

  DOKINA O. B.; NAUMOVA I. I.; STREPIXEEV YU. A.; VIRIN L. I.; POPOVA I. YU+, ZH. BCEC. XIM. O-BA, 32,(1987) N 1, 115-117

  摘要：

  DOI：

文献信息

• [EN] HETEROARYL COMPOUNDS AND THEIR USE<br/>[FR] COMPOSÉS HÉTÉROARYLE ET LEUR UTILISATION
  申请人：MINORYX THERAPEUTICS S L

  公开号：WO2018122775A1

  公开（公告）日：2018-07-05

  The application is directed to compounds of formula (I): and their salts and solvates, wherein R1, R2, R3, A1, A2, A3, and n are as set forth in the specification, as well as to a method for their preparation, pharmaceutical compositions comprising the same, and use thereof for the treatment and/or prevention of a lysosomal storage disease, such as Gaucher's, and other diseases or disorders that are synucleinopathies.

  该申请涉及式(I)的化合物及其盐和溶剂合物，其中R1、R2、R3、A1、A2、A3和n如规范中所述，以及它们的制备方法，包含它们的药物组合物，以及用于治疗和/或预防溶酶体贮积病（如高雪氏病）和其他α-突触核蛋白病的用途。
• Biguanide compositions and methods of treating metabolic disorders
  申请人：Elcelyx Therapeutics, Inc.

  公开号：US10028923B2

  公开（公告）日：2018-07-24

  Provided herein are methods for treating certain conditions, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a biguanide or related heterocyclic compound, e.g., metformin. Also provided herein are biguanide or related heterocyclic compound compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.

  本文提供了通过施用包含双胍类或相关杂环化合物（如二甲双胍）的组合物来治疗某些疾病（包括糖尿病、肥胖症和其他代谢性疾病、失调或病症）的方法。本文还提供了双胍类或相关杂环化合物组合物及其用于本发明方法的制备方法。本文还提供了包含二甲双胍及其盐类的组合物和使用方法。
• DOKINA O. B.; NAUMOVA I. I.; STREPIXEEV YU. A.; VIRIN L. I.; POPOVA I. YU+, ZH. BCEC. XIM. O-BA, 32,(1987) N 1, 115-117
  作者：DOKINA O. B.、 NAUMOVA I. I.、 STREPIXEEV YU. A.、 VIRIN L. I.、 POPOVA I. YU+

  DOI：——

  日期：——
• Biguanide Compositions and Methods of Treating Metabolic Disorders
  申请人：Baron Alain D.

  公开号：US20130095140A1

  公开（公告）日：2013-04-18

  Provided herein are methods for treating certain conditions, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a biguanide or related heterocyclic compound, e.g., metformin. Also provided herein are biguanide or related heterocyclic compound compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.
• US20140341986A1
  申请人：——

  公开号：US20140341986A1

  公开（公告）日：2014-11-20