毒理性
◉ 母乳喂养期间使用总结：本记录中的信息是指将碘氟潘I 123作为诊断剂的使用。核医学协会建议在给予碘氟潘I 123示踪剂后至少中断母乳喂养1天，可能长达6天；制造商表示，在给予哺乳母亲碘氟潘I 123后，应中断母乳喂养6天。然而，这段时间是基于I 123被其他碘同位素污染的假设，这种情况已不再存在。可能适当缩短这段时间。在中断期间，应定期且完全排空乳房。如果母亲在检查前已经挤出并保存了乳汁，她可以在哺乳中断期间用这些乳汁喂养婴儿。母亲在哺乳中断期间泵出的乳汁可以丢弃，或者冷藏保存，并在泵奶后经过10个物理半衰期，大约5.5天后，给予婴儿。
担心乳汁中放射性水平的母亲可以要求在医院核医学科进行检测。当放射性水平达到安全水平时，她可以恢复母乳喂养。已经发布了一种测量乳汁放射性并确定母亲可以安全恢复母乳喂养的时间的方法。
◉ 对哺乳婴儿的影响：截至修订日期，没有找到相关的已发布信息。
◉ 对泌乳和母乳的影响：截至修订日期，没有找到相关的已发布信息。
◉ Summary of Use during Lactation:Information in this record refers to the use of ioflupane I 123 as a diagnostic agent. The Society of Nuclear Medicine recommends that breastfeeding be interrupted for at least 1 day and possibly up to 6 days following tracer doses of ioflupane I 123; the manufacturer states that breastfeeding should be interrupted for 6 days after administration of ioflupane I 123 to a nursing mother. However, this time period is based on the presumption that I 123 is contaminated with other iodine isotopes, which is no longer the case. A shorter time might be appropriate. During the period of interruption, the breasts should be emptied regularly and completely. If the mother has expressed and saved milk prior to the examination, she can feed it to the infant during the period of nursing interruption. The milk that is pumped by the mother during the time of breastfeeding interruption can either be discarded or stored refrigerated and given to the infant after 10 physical half-lives, or about 5.5 days, have elapsed since pumping.
Mothers concerned about the level of radioactivity in their milk could ask to have it tested at a nuclear medicine facility at their hospital. When the radioactivity is at a safe level, she may resume breastfeeding. A method for measuring milk radioactivity and determining the time when a mother can safely resume breastfeeding has been published.
◉ Effects in Breastfed Infants:Relevant published information was not found as of the revision date.
◉ Effects on Lactation and Breastmilk:Relevant published information was not found as of the revision date.
来源:Drugs and Lactation Database (LactMed)
