3β-(Hydroxy)-8-methyl-8-azabicyclo[3.2.1]octane-2β-carboxylic acid methyl ester | 7143-09-1

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 托烷生物碱
• 英文名称: 3β-(Hydroxy)-8-methyl-8-azabicyclo[3.2.1]octane-2β-carboxylic acid methyl ester
• 英文别名: 8-azabicyclo[3.2.1]octane-2-carboxylic acid, 3-hydroxy-8-methyl-, methyl ester, (1R,2R,3S,5S)-；methyl (2R,3S)-3-hydroxy-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate
• CAS: 7143-09-1
• 化学式: C₁₀H₁₇NO₃
• 分子量: 199.25
• InChiKey: QIQNNBXHAYSQRY-ABIFROTESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3β-(Hydroxy)-8-methyl-8-azabicyclo[3.2.1]octane-2β-carboxylic acid methyl ester 、 苯甲酰氯 以55%的产率得到
  参考文献：
  名称：

  CARROLL, F. IVY;LEWIN, ANITA H.;ABRAHAM, PHILIP;PARHAM, KAROL;BOJA, JOHN +, J. MED. CHEM., 34,(1991) N, C. 883-886

  摘要：

  DOI：
• 作为产物：
  描述：

  Methyl (2R)-8-methyl-3-oxo-8-azabicyclo[3.2.1]octane-2-carboxylate 、 硼氢化钠 以52%的产率得到
  参考文献：
  名称：

  CARROLL, F. IVY;LEWIN, ANITA H.;ABRAHAM, PHILIP;PARHAM, KAROL;BOJA, JOHN +, J. MED. CHEM., 34,(1991) N, C. 883-886

  摘要：

  DOI：

文献信息

• NOVEL COCAINE HAPTENS AND NANOFIBER-BASED COCAINE VACCINES
  申请人：Zhou Jia

  公开号：US20170239346A1

  公开（公告）日：2017-08-24

  Certain embodiments are directed to chemically defined self-adjuvanting cocaine vaccines composed of novel cocaine haptens and self-assembling peptide domains.

  某些实施例涉及化学定义的自免疫可升级的可卡因疫苗，由新型可卡因半抗原和自组装的肽结构域组成。
• Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same
  申请人：Xenova Research Limited

  公开号：US20030069400A1

  公开（公告）日：2003-04-10

  Hapten-carrier conjugates capable of eliciting anti-hapten antibodies in vivo by administering, in a therapeutic composition, are disclosed. Methods of preparing said conjugates and therapeutic compositions are also disclosed. Where the hapten is a drug of abuse, a therapeutic composition containing the hapten-carrier conjugate is particularly useful in the treatment of drug addiction, more particularly, cocaine addiction. Passive immunization using antibodies raised against conjugates of the instant invention is also disclosed. The therapeutic composition is suitable for co-therapy with other conventional drugs.

  本发明公开了能够通过在治疗组合物中给予而在体内引发抗半抗原抗体的半抗原-载体偶联物。本发明还公开了制备该偶联物和治疗组合物的方法。当半抗原是一种药物成瘾时，含有半抗原-载体偶联物的治疗组合物在治疗药物成瘾，尤其是可卡因成瘾方面特别有用。还公开了使用针对本发明偶联物所产生的抗体进行被动免疫的方法。该治疗组合物适用于与其他常规药物一起进行联合治疗。
• Hapten-carrier conjugates for use in drug abuse therapy and methods for preparation of same
  申请人：Swain Philip A.

  公开号：US20100068222A1

  公开（公告）日：2010-03-18

  Hapten-carrier conjugates capable of eliciting anti-hapten antibodies in vivo by administering, in a therapeutic composition, are disclosed. Methods of preparing said conjugates and therapeutic compositions are also disclosed. Where the hapten is a drug of abuse, a therapeutic composition containing the hapten-carrier conjugate is particularly useful in the treatment of drug addiction, more particularly, cocaine addiction. Passive immunization using antibodies raised against conjugates of the instant invention is also disclosed. The therapeutic composition is suitable for co-therapy with other conventional drugs.

  本发明揭示了能够通过在治疗组合物中给予而在体内引起抗卟胶原抗体的卟胶原载体共轭物。本发明还揭示了制备该共轭物和治疗组合物的方法。当卟胶原是一种药物滥用物时，含有卟胶原载体共轭物的治疗组合物在治疗药物成瘾，更特别地，在可卡因成瘾的治疗中特别有用。本发明还揭示了使用针对本发明共轭物所提高的抗体进行被动免疫的方法。该治疗组合物适用于与其他传统药物联合治疗。
• HAPTEN-CARRIER CONJUGATES FOR USE IN DRUG-ABUSE THERAPY AND METHODS FOR PREPARATION OF SAME
  申请人：Swain Philip A.

  公开号：US20100209449A1

  公开（公告）日：2010-08-19

  Hapten-carrier conjugates capable of eliciting anti-hapten antibodies in vivo by administering, in a therapeutic composition, are disclosed. Methods of preparing said conjugates and therapeutic compositions are also disclosed. Where the hapten is a drug of abuse, a therapeutic composition containing the hapten-carrier conjugate is particularly useful in the treatment of drug addiction, more particularly, cocaine addiction. Passive immunization using antibodies raised against conjugates of the instant invention is also disclosed. The therapeutic composition is suitable for co-therapy with other conventional drugs.

  本发明揭示了能够通过在治疗组合物中给予而在体内引发抗卟胶原抗体的卟胶原载体共轭物。本发明还揭示了制备该共轭物和治疗组合物的方法。当卟胶原是药物滥用时，含有卟胶原载体共轭物的治疗组合物在治疗药物成瘾，特别是可卡因成瘾方面特别有用。本发明还揭示了使用针对本发明共轭物所产生的抗体进行被动免疫的方法。该治疗组合物适用于与其他传统药物联合治疗。
• HAPTEN-CARRIER CONJUGATES WITH BACTERIAL TOXINS HAVING A SIGNAL PEPTIDE AS CARRIER AND THEIR USE IN IMMUNOGENIC COMPOSITIONS
  申请人：Henry William

  公开号：US20120100171A1

  公开（公告）日：2012-04-26

  This invention relates to immunogenic compositions for inducing an immune response against an antigen of interest. In particular, the invention provides immunogenic compositions comprising an antigen-carrier conjugate, wherein the carrier is a bacterial toxin that contains a signal peptide. The invention also provides methods of generating immunogenic compositions with enhanced immunogenicity, comprising adding a signal peptide to the bacterial carrier in an antigen-carrier conjugate, such as a hapten-carrier conjugate. The invention also provides methods for inducing an immune response to a hapten in a subject using these immunogenic compositions.

  本发明涉及用于诱导针对感兴趣抗原的免疫反应的免疫原性组合物。具体而言，本发明提供包含抗原-载体共轭物的免疫原性组合物，其中载体是含有信号肽的细菌毒素。本发明还提供了增强免疫原性的免疫原性组合物的生成方法，包括将信号肽添加到细菌载体中的抗原-载体共轭物中，例如半抗原-载体共轭物。本发明还提供了使用这些免疫原性组合物诱导受体中半抗原的免疫反应的方法。