二水合氯化钡

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 碱土金属盐
• 中文名称: 二水合氯化钡
• 中文别名: 二水合氯酸钡；氯化钡，二水；氯化钡(二水)；二水氯化钡；氯化钡,二水
• 英文名称: barium(2+);dichloride;dihydrate
• 化学式: BaCl2H4O2
• 分子量: 244.26
• InChiKey: PWHCIQQGOQTFAE-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -8.02
• 重原子数：
  5
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  2
• 氢给体数：
  2
• 氢受体数：
  4

ADMET

毒理性

• 暴露途径

该物质可以通过吸入其气溶胶和通过吞食被吸收进人体。

The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

来源:ILO-WHO International Chemical Safety Cards (ICSCs)

毒理性

• 吸入症状

咳嗽。喉咙痛。请参阅摄入部分。

Cough. Sore throat. See Ingestion.

来源:ILO-WHO International Chemical Safety Cards (ICSCs)

毒理性

• 皮肤症状

Redness.

Redness.

来源:ILO-WHO International Chemical Safety Cards (ICSCs)

毒理性

• 眼睛症状

Redness.

Redness.

来源:ILO-WHO International Chemical Safety Cards (ICSCs)

毒理性

• 摄入症状

腹部疼痛。恶心。腹泻。呕吐。虚弱。迟钝。昏迷。

Abdominal pain. Nausea. Diarrhoea. Vomiting. Weakness. Dullness. Unconsciousness.

来源:ILO-WHO International Chemical Safety Cards (ICSCs)

反应信息

• 作为反应物：
  描述：

  4,5-Diamino-6-hydroxy-2-mercaptopyrimidine hemisulfate hydrate 、 二水合氯化钡 在 barium sulfate 作用下， 以 水 为溶剂， 反应 0.5h， 以to provide 9.22 g (66% yield) of 5,6-diamino-2-mercapto-pyrimidin-4-ol hydrochloride as beige solid的产率得到5,6-diamino-2-mercapto-pyrimidin-4-ol hydrochloride
  参考文献：
  名称：

  SUBSTITUTED PTERIDINES FOR THE TREATMENT AND PREVENTION OF VIRAL INFECTIONS

  摘要：

  三取代喜树碱和四取代喜树碱对某些类型的病毒感染表现出显著和选择性的活性，特别是它们选择性地抑制丙型肝炎病毒的复制，并且对于预防和治疗此类感染是有用的。

  公开号：

  US20090318456A1

文献信息

• Immunosuppressive effects of pteridine derivatives
  申请人：Waer Jozef Albert Mark

  公开号：US20060287314A1

  公开（公告）日：2006-12-21

  This invention relates to a group of trisubstituted and tetrasubstituted pteridine derivatives, their pharmaceutically acceptable salts, N-oxides, solvates, dihydro- and tetrahydro-derivatives and enantiomers, possessing unexpectedly desirable pharmaceutical properties, in particular which are highly active immunosuppressive agents, and as such are useful in the treatment in transplant rejection and/or in the treatment of certain inflammatory diseases. These compounds are also useful in preventing or treating cardiovascular disorders, allergic conditions, disorders of the central nervous system and cell proliferative disorders.

  本发明涉及一组三取代和四取代喋啉衍生物，其药学上可接受的盐、N-氧化物、溶剂合物、二氢和四氢衍生物和对映体，具有意外的理想药理特性，特别是高度活性的免疫抑制剂，并因此在移植排斥和/或治疗某些炎症性疾病方面有用。这些化合物还有助于预防或治疗心血管疾病、过敏症、中枢神经系统疾病和细胞增殖性疾病。
• SUBSTITUTED PYRIMIDIN-5-CARBOXAMIDES 281
  申请人：GILL Adrian Liam

  公开号：US20090264401A1

  公开（公告）日：2009-10-22

  A compound of formula (I): and pharmaceutically-acceptable salts thereof wherein the variable groups are defined within; their use in the inhibition of 11βHSD1, processes for making them and pharmaceutical compositions comprising them are also described.

  公式（I）的化合物及其药用可接受盐，其中变量基团的定义如下；还描述了它们在抑制11βHSD1中的用途，制造它们的过程以及包含它们的制药组合物。
• Pteridine derivatives for the treatment of septic shock and tnf-a-related diseases
  申请人：Waer Mark Jozef Albert

  公开号：US20070004721A1

  公开（公告）日：2007-01-04

  This invention relates to the use of a group of pteridine derivatives, their pharmaceutically acceptable salts, N-oxides, solvates, dihydro- and tetrahydroderivatives and enantiomers, for the manufacture of a medicament for the prevention or treatment of TNF-α related disorders.

  该发明涉及使用一组黄素衍生物及其医药上可接受的盐、N-氧化物、溶剂合物、二氢-和四氢衍生物和对映体，制造用于预防或治疗与TNF-α相关的疾病的药物。
• Pteridine derivatives useful for making pharmaceutical compositions
  申请人：Waer Jozef Albert Mark

  公开号：US20070032477A1

  公开（公告）日：2007-02-08

  This invention relates to a group of substituted pteridine derivatives, their pharmaceutically acceptable salts, N-oxides, solvates, dihydro- and tetrahydro-derivatives, and enantiomers, possessing unexpectedly desirable pharmaceutical properties, in particular which are highly active immunosuppressive agents, and as such are useful in the treatment in transplant rejection and/or in the treatment of certain inflammatory diseases. These derivatives are also useful in preventing or treating cardiovascular disorders, allergic conditions, disorders of the central nervous system, TNF-α related disorders, viral diseases, inflammatory bowel diseases and cell proliferative disorders.

  本发明涉及一类取代的喹噁啉衍生物，其药学上可接受的盐、N-氧化物、溶剂合物、二氢和四氢衍生物以及对映体，具有出乎意料的理想药理特性，尤其是高活性的免疫抑制剂，因此在移植排斥和/或某些炎症性疾病的治疗中非常有用。这些衍生物还可用于预防或治疗心血管疾病、过敏性疾病、中枢神经系统疾病、TNF-α相关疾病、病毒性疾病、炎症性肠病和细胞增殖性疾病。

表征谱图