Barium(2+);dinitrate

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 碱土金属氧阴离子化合物
• 英文名称: Barium(2+);dinitrate
• 化学式: BaN2O6
• 分子量: 261.34
• InChiKey: IWOUKMZUPDVPGQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.86
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  126
• 氢给体数：
  0
• 氢受体数：
  6

ADMET

代谢

硫酸钡化合物通过摄入和吸入被吸收，其程度取决于个别化合物。在人体内，大部分的钡存在于骨骼中，而少量存在于肌肉、脂肪、皮肤和结缔组织中。钡在体内不被代谢，但它可能会被运输或结合到复合物或组织中。钡通过尿液和粪便排出。摄入一定量的硝酸盐和亚硝酸盐是人类氮循环的正常部分。在适当的条件下，硝酸盐可以在胃肠道内转化为亚硝酸盐，显著增加硝酸盐的毒性。硝酸盐的主要代谢途径是转化为亚硝酸盐，然后转化为氨。亚硝酸盐、硝酸盐及其代谢物通过尿液排出。(L1137, L214)

Barium compounds are absorbed via ingestion and inhalation, the extent of which depends on the individual compound. In the body, the majority of the barium is found in the bone, while small amounts exists in the muscle, adipose, skin, and connective tissue. Barium is not metabolized in the body, but it may be transported or incorporated into complexes or tissues. Barium is excreted in the urine and faeces. Intake of some amount of nitrates and nitrites is a normal part of the nitrogen cycle in humans. In vivo conversion of nitrates to nitrites can occur in the gastrointestional tract under the right conditions, significantly enhancing nitrates' toxic potency. The major metabolic pathway for nitrate is conversion to nitrite, and then to ammonia. Nitrites, nitrates, and their metabolites are excreted in the urine. (L1137, L214)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 毒性总结

钡是一种竞争性的钾通道拮抗剂，它可以阻止细胞内钾离子的被动外流，导致钾离子从细胞外向细胞内转移。细胞内钾离子的转移导致静息膜电位的降低，使得肌肉纤维在电学上不可兴奋，从而引起瘫痪。钡的这些效应部分也可能是因为钡引起的神经肌肉阻滞和膜去极化。硝酸盐的毒性是由于它进入体内后转化为亚硝酸盐。亚硝酸盐会导致氧合血红蛋白的自催化氧化，转化为过氧化氢和高铁血红蛋白。高铁血红蛋白水平的升高是一种称为高铁血红蛋白血症的条件，其特征是组织缺氧，因为高铁血红蛋白无法结合氧气。(A2450, L1613, L214)

Barium is a competitive potassium channel antagonist that blocks the passive efflux of intracellular potassium, resulting in a shift of potassium from extracellular to intracellular compartments. The intracellular translocation of potassium results in a decreased resting membrane potential, making the muscle fibers electrically unexcitable and causing paralysis. Some of these barium's effects may also be due to barium induced neuromuscular blockade and membrane depolarization. Nitrate's toxicity is a result of it's conversion to nitrite once in the body. Nitrite causes the autocatalytic oxidation of oxyhemoglobin to hydrogen peroxide and methemoglobin. This elevation of methemoglobin levels is a condition known as methemoglobinemia, and is characterized by tissue hypoxia, as methemoglobin cannot bind oxygen. (A2450, L1613, L214)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 致癌性证据

A4；不能分类为人类致癌物。/钡和可溶性化合物，如Ba/

A4; Not classifiable as a human carcinogen. /Barium and soluble compounds, as Ba/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌物分类

摄入硝酸盐或亚硝酸盐，在导致内源性亚硝化的条件下，可能对人类具有致癌性（2A组）。

Ingested nitrate or nitrite under conditions that result in endogenous nitrosation is probably carcinogenic to humans (Group 2A). (L135)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 健康影响

不同钡化合物的健康影响取决于化合物在水中或胃内容物中的溶解程度。在低剂量时，钡作为一种肌肉刺激剂，而较高剂量则影响神经系统，导致心脏不规律、震颤、虚弱、焦虑、呼吸困难、麻痹甚至可能死亡。钡还可能引起胃肠功能紊乱，损害肾脏并导致体重下降。硝酸盐和亚硝酸盐中毒会导致高铁血红蛋白血症。亚硝酸盐可能导致妊娠并发症和发育影响。它们也可能具有致癌性。

The health effects of the different barium compounds depend on how well the compound dissolves in water or the stomach contents. At low doses, barium acts as a muscle stimulant, while higher doses affect the nervous system, causing cardiac irregularities, tremors, weakness, anxiety, dyspnea, paralysisand possibly death. Barium may also cause gastrointestinal disturbances, damage the kidneys and cause decreases in body weight. Nitrate and nitrite poisoning causes methemoglobinemia. Nitrites may cause pregnancy complications and developmental effects. They may also be carcinogenic. (L1137, L214)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 暴露途径

该物质可以通过吸入和摄入被身体吸收。

The substance can be absorbed into the body by inhalation and by ingestion.

来源:ILO-WHO International Chemical Safety Cards (ICSCs)

反应信息

• 作为反应物：
  描述：

  Barium(2+);dinitrate 生成 无水氧化钡
  参考文献：
  名称：

  ODAN, KEDZI;SAKATO, YASUO

  摘要：

  DOI：
• 作为产物：
  描述：

  barium carbonate 、 硝酸 以9%的产率得到
  参考文献：
  名称：

  NIKOLOVA, D.;MANEVA, M., GOD. VISSH. XIMIKOTEXNOL. INST., SOFIYA, 30,(1988) N, S. 123-131

  摘要：

  DOI：

文献信息

• Synthesis of hydroxylamine salts
  申请人：The United States of America as represented by the Secretary of the Navy

  公开号：US04954328A1

  公开（公告）日：1990-09-04

  Hydroxylamine perchlorate or nitrate is prepared by forming an alcohol-hyxylamine solution from reacting a slurry of hydroxylamine sulfate in alcohol with sodium alkoxide, reacting perchloric acid or nitric and therewith to form the desired salt, and separating the salt.

  羟胺硫酸盐在醇中形成醇-羟胺溶液，并与钠醇化物反应，生成羟胺高锰酸盐或硝酸盐，并将高氯酸或硝酸与之反应，形成所需的盐，并分离盐。
• Polyester polymerization catalyst, polyester produced by using the same, and process for producing polyester
  申请人：——

  公开号：US20030083191A1

  公开（公告）日：2003-05-01

  This invention provides a novel polymerization catalyst other than antimony compounds, polyester produced by using the same and a process for producing polyester. The polycondensation catalyst of this invention is a polyester polymerization catalyst comprising an aluminum compound and a phosphorus compound having a specific structure. Further, this invention relates to polyester produced by using this polyester polymerization catalyst and a process for producing polyester. Further, this invention relates to fibers, films and hollow molded articles mprising the polyester.

  本发明提供了一种新型聚合催化剂，除了锑化合物外，还提供了由该催化剂制备的聚酯以及制备聚酯的方法。本发明的聚酯缩聚催化剂是一种聚酯聚合催化剂，包括一种铝化合物和一种具有特定结构的磷化合物。此外，本发明还涉及使用该聚酯聚合催化剂制备的聚酯和制备聚酯的方法。此外，本发明还涉及由该聚酯制备的纤维、薄膜和空心成型制品。
• Insecticidal composition
  申请人：——

  公开号：US04873084A1

  公开（公告）日：1989-10-10

  It was discovered that the chemical compositions, comprising ammoniumpentaborate and alkali metal and/or alkaline earth metal: sulfates, -sulfites and/or -hydrophosphates are excellent pesticides against wood decaying insects and fungi. The compositions of matter are also useful as fire retardants and anti-smoldering agents in textiles, wood materials and synthetic polymers. Mixtures of bariumtriborate and these barium salts (SO.sub.3, SO.sub.4, and/or HPO.sub.4) are useful as fire retardants in cellulose materials, paints, adhesives and synthetic polymers. The barium- and calcium-triborate compositions also act as pesticides and are useful in wood preservation against wood boring insects and wood decaying fungi. Ammoniumpentaborate (NH.sub.4.B.sub.5 O.sub.8.4 H.sub.2 O), ammoniumtetraborate [(NH.sub.4).sub.2.B.sub.4 O.sub.7.4 H.sub.2 O] and disodiumoctaborate (Na.sub.2 B.sub.8 O.sub.13.4 H.sub.2 O) undergo reaction in water solution with barium and calcium salts providing bariumtriborate and calciumtriborate, respectively.

  发现由氨基五硼酸盐和碱金属和/或碱土金属：硫酸盐，-亚硫酸盐和/或-磷酸盐组成的化学成分对木材腐朽昆虫和真菌是优秀的杀虫剂。这些物质的组成也可用作纺织品，木材和合成聚合物的阻燃剂和防烟剂。钡三硼酸盐和这些钡盐（SO.sub.3，SO.sub.4和/或HPO.sub.4）的混合物在纤维素材料，油漆，粘合剂和合成聚合物中作为阻燃剂有用。钡-和钙-三硼酸盐组合物也具有杀虫剂作用，并可用于防止木材蛀虫和木材腐朽真菌。氨基五硼酸盐（NH.sub.4.B.sub.5 O.sub.8.4 H.sub.2 O），氨基四硼酸盐[(NH.sub.4).sub.2.B.sub.4 O.sub.7.4 H.sub.2 O]和八水合硼酸二钠（Na.sub.2 B.sub.8 O.sub.13.4 H.sub.2 O）在水溶液中与钡盐和钙盐反应，分别提供钡三硼酸盐和钙三硼酸盐。
• 2-Pyrimidinyl Pyrazolopyridine Erbb Kinase Inhibitors
  申请人：Uehling Edward David

  公开号：US20080051395A1

  公开（公告）日：2008-02-28

  The present invention provides 2-pyrimidinyl pyrazolopyridine compounds, compositions containing the same, as well as processes for the preparation and their use as pharmaceutical agents.

  本发明提供了2-嘧啶基吡唑并[3,4-d]吡啶化合物，包含它们的组合物，以及制备它们的过程和它们作为药物的用途。
• COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM
  申请人：Whitten Jeffrey P.

  公开号：US20110263612A1

  公开（公告）日：2011-10-27

  Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

  本文描述了一些化合物和含有这些化合物的药物组合物，这些化合物可以调节储存操作钙（SOC）通道的活性。本文还介绍了使用这种SOC通道调节剂的方法，单独或与其他化合物结合，用于治疗需要抑制SOC通道活性的疾病或病症。