5-chloro-2-hydroxy-biphenyl-3-carboxylic acid phenyl ester | 4906-71-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 缩酚酸和缩酚酸环醚类
• 英文名称: 5-chloro-2-hydroxy-biphenyl-3-carboxylic acid phenyl ester
• 英文别名: 5-Chlor-2-hydroxy-biphenyl-3-carbonsaeure-phenylester；Phenyl 5-chloro-2-hydroxy-3-phenylbenzoate
• CAS: 4906-71-2
• 化学式: C₁₉H₁₃ClO₃
• 分子量: 324.763
• InChiKey: VZDCHIPWHJFPCH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-chloro-2-hydroxy-biphenyl-3-carboxylic acid phenyl ester 、 正丁胺 生成 5-chloro-2-hydroxy-biphenyl-3-carboxylic acid butylamide
  参考文献：
  名称：

  Jules et al., 1956, vol. 45, p. 277,281

  摘要：

  DOI：
• 作为产物：
  描述：

  5-Chlor-3-phenylsalicylsaeure 、 苯酚 在 三氯氧磷 作用下， 生成 5-chloro-2-hydroxy-biphenyl-3-carboxylic acid phenyl ester
  参考文献：
  名称：

  Specific immune response to parietaria judaica plant profilin: a low t cell proliferative response supports high ige and skin prick test

  摘要：

  Background: allergic disease caused by Parietaria judaica (Pj) has been widely documented in Mediterranean area. Profilins have been identified as widely distributed allergenic proteins. The role of Pj profilin in specific immune response in Pj-sensitized patients is unknown. Methods: skin prick test and determination of specific and total IgE levels in serum were performed in all patients (n = 28) and non-allergic controls (n = 18). Peripheral blood mononuclear cells (PBMC) were isolated from both groups and stimulated with crude extract or highly purified Pj profilin. The production of type I and type II cytokines was determined by specific and polyclonal stimuli in patients and controls. T-cell lines specific to Pj profilin were established and cross-reactivity with another highly purified profilin from Phleum pratense (Phl p) was evaluated. Results: Pj profilin-sensitized patients showed a small but significantly increased in T-cell proliferative response to this profilin compared with non-atopic controls. The production of interleukin (IL)-4 and interferon (IFN)-γ in response to the specific stimulus was undetectable. However, the production of IL-4 in response to a polyclonal stimulus [phytohemagglutinin (PHA)] was significantly higher in atopic patients than in controls. The T-cell response did not correlate with the magnitude of response to skin prick tests with Pj profilin or with Pj-specific serum IgE levels. In addition, the production of IL-4 in response to a polyclonal stimulus (PHA) did not correlate with the individual skin prick tests to Pj profilin or with Pj-specific IgE levels in serum. The T-cell lines tested showed no cross-reactivity with Phl p profilin. Conclusions: our results suggest that Pj profilin is partly responsible for the T-cell-mediated response in patients allergic to Pj. The high skin reactivity to Pj profilin is these patients was accompanied by a small increase in the T-cell response to this profilin. The response was highly specific since Pj profilin specific T-cell lines showed no cross-reactivity with a highly homologous profilin from Phl p. The lack of correlation between the proliferative T-cell response and polyclonal IL-4 production with allergen-specific serum IgE and skin reactivity probably indicates that some of the responding T-cells may be involved in immune reactions other than those supporting IgE production.

  DOI：

  10.1016/s0301-0546(02)79092-7

文献信息

• Halogenated-3-phenylsalicylanilides
  申请人：MONSANTO CHEMICALS

  公开号：US02865861A1

  公开（公告）日：1958-12-23