tert-butyl 3-methyl-2-oxo-1,8-diazaspiro[4.5]decane-8-carboxylate | 1234481-61-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂螺癸烷衍生物
• 英文名称: tert-butyl 3-methyl-2-oxo-1,8-diazaspiro[4.5]decane-8-carboxylate
• CAS: 1234481-61-8
• 化学式: C₁₄H₂₄N₂O₃
• 分子量: 268.356
• InChiKey: UFVFHFUJILFRAE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  58.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  tert-butyl 3-methyl-2-oxo-1,8-diazaspiro[4.5]decane-8-carboxylate 在 劳森试剂 作用下， 以 甲苯 为溶剂， 反应 2.0h， 以65%的产率得到Tert-butyl 3-methyl-2-sulfanylidene-1,8-diazaspiro[4.5]decane-8-carboxylate
  参考文献：
  名称：

  N-Boc 4-nitropiperidine: preparation and conversion into a spiropiperidine analogue of the eastern part of maraviroc

  摘要：

  Previously unreported N-Boc 4-nitropiperidine was prepared in two steps from N-Boc-piperidone. The synthetic utility of this new intermediate was demonstrated by the development of a new and simple route to spirolactam piperidines. Further synthetic work involving a challenging triazole cyclisation allowed the preparation of a spiropiperidine analogue of the eastern part of maraviroc. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.04.046
• 作为产物：
  描述：

  Tert-butyl 4-(2-(methoxycarbonyl)propyl)-4-nitropiperidine-1-carboxylate 在 氢气 作用下， 反应 12.0h， 生成 tert-butyl 3-methyl-2-oxo-1,8-diazaspiro[4.5]decane-8-carboxylate
  参考文献：
  名称：

  N-Boc 4-nitropiperidine: preparation and conversion into a spiropiperidine analogue of the eastern part of maraviroc

  摘要：

  Previously unreported N-Boc 4-nitropiperidine was prepared in two steps from N-Boc-piperidone. The synthetic utility of this new intermediate was demonstrated by the development of a new and simple route to spirolactam piperidines. Further synthetic work involving a challenging triazole cyclisation allowed the preparation of a spiropiperidine analogue of the eastern part of maraviroc. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.04.046

文献信息

• [EN] HETEROCYCLIC AMIDE AND UREA COMPOUNDS AS JAK2 INHIBITORS<br/>[FR] COMPOSÉS D'URÉE ET D'AMIDE HÉTÉROCYCLIQUES EN TANT QU'INHIBITEURS DE JAK2
  申请人：[en]AJAX THERAPEUTICS, INC.

  公开号：WO2024035627A1

  公开（公告）日：2024-02-15

  The present disclosure provides heterocyclic amide and urea compounds and compositions thereof useful for inhibiting JAK2.
• N-Boc 4-nitropiperidine: preparation and conversion into a spiropiperidine analogue of the eastern part of maraviroc
  作者：Philip Mullen、Hugues Miel、M. Anthony McKervey

  DOI：10.1016/j.tetlet.2010.04.046

  日期：2010.6

  Previously unreported N-Boc 4-nitropiperidine was prepared in two steps from N-Boc-piperidone. The synthetic utility of this new intermediate was demonstrated by the development of a new and simple route to spirolactam piperidines. Further synthetic work involving a challenging triazole cyclisation allowed the preparation of a spiropiperidine analogue of the eastern part of maraviroc. (C) 2010 Elsevier Ltd. All rights reserved.