1,2-Bis-<2-thioxo-5-methyl-tetrahydro-1,3,5-thiadiazinyl-(3)>-aethan | 27090-72-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 二硫代氨基甲酸及其衍生物
• 英文名称: 1,2-Bis-<2-thioxo-5-methyl-tetrahydro-1,3,5-thiadiazinyl-(3)>-aethan
• 英文别名: 3,3'-Ethylenbis(tetrahydro-5-methyl-2H-1,3,5-thiadiazine-2-thione)；5,5'-dimethyl-3,3'-ethane-1,2-diyl-bis-[1,3,5]thiadiazinane-2-thione；2H-1,3,5-Thiadiazine-2-thione, 3,3'-(1,2-ethanediyl)bis[tetrahydro-5-methyl-；5-methyl-3-[2-(5-methyl-2-sulfanylidene-1,3,5-thiadiazinan-3-yl)ethyl]-1,3,5-thiadiazinane-2-thione
• CAS: 27090-72-8
• 化学式: C₁₀H₁₈N₄S₄
• 分子量: 322.544
• InChiKey: RGFNAVKFMNZAEN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  128
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  聚合甲醛 、 盐酸甲胺 、 disodium ethylenebis(dithiocarbamate) 生成 1,2-Bis-<2-thioxo-5-methyl-tetrahydro-1,3,5-thiadiazinyl-(3)>-aethan
  参考文献：
  名称：

  RIECHE; MARTIN; SCHADE, Archiv der Pharmazie, 1963, vol. 296, p. 770 - 784

  摘要：

  DOI：

文献信息

• Synthesis and antifungal activity of 3,3'-ethylenebis(5-alkyl-1,3,5-thiadiazine-2-thiones)
  作者：Mostafa A. Hussein、Abdel-Nasser El-Shorbagi、Abdel-Raouf Khallil

  DOI：10.1002/1521-4184(200110)334:10<305::aid-ardp305>3.0.co;2-o

  日期：2001.10

  In a search for promising antifungal compounds, nine new 3,3'-ethylenebis(5-alkyl-1,3,5-thiadiazine-2-thiones) were synthesized by the reaction of ethylene diamine, carbon disulfide, formaldehyde, and the appropriate alkyl amine. The title compounds were tested for their antifungal activity in vitro against pathogenic (Trichophyton rubrum and Candida albicans), phytopathogenic (Penicillum expansum, Trichoderma hazianum, and Fasarium oxysporum), and aflatoxin producing (Aspergillus flavus) fungi. These compounds exhibited varied inhibitory effects on growth or sporulation of some tested fungal species.
• GHEORGHE, S. M.;BARBULESCU, N.;COSTEA, P.;IONESCU, E.;MIHALCEA, V.
  作者：GHEORGHE, S. M.、BARBULESCU, N.、COSTEA, P.、IONESCU, E.、MIHALCEA, V.

  DOI：——

  日期：——
• RIECHE; MARTIN; SCHADE, Archiv der Pharmazie, 1963, vol. 296, p. 770 - 784
  作者：RIECHE、MARTIN、SCHADE

  DOI：——

  日期：——