trans-{Pt(Cl)(H2O)((15)NH3)2}(1+) | 142186-47-8

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物
• 英文名称: trans-{Pt(Cl)(H2O)((15)NH3)2}(1+)
• 英文别名: cis-{Pt((15)NH3)2Cl(H2O)}(1+)；cis-[Pt((15)NH3)2Cl(H2O)](1+)；cis-[PtCl((15)NH3)2(H2O)](1+)
• CAS: 142186-47-8；78039-62-0
• 化学式: ClH₈N₂OPt
• 分子量: 284.596
• InChiKey: ABAUMWKZAPJXJX-QYOIXUNQSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  trans-{Pt(Cl)(H2O)((15)NH3)2}(1+) 、 cis-Pt((15)NH3)2Cl2 、 cis-diamminediaquaplatinum(II) 在 NaOH 作用下， 以 水 为溶剂， 生成 cis-{Pt((15)NH3)2Cl(OH)} 、 {(Pt((15)NH3)2)2(μ-Cl)(μ-OH)}(2+)
  参考文献：
  名称：

  Appleton, Trevor G.; Hall, John R.; Ralph, Stephen F., Inorganic Chemistry, 1989, vol. 28, # 10, p. 1989 - 1993

  摘要：

  DOI：
• 作为产物：
  描述：

  在 sodium chloride 作用下， 以 水 为溶剂， 生成 trans-{Pt(Cl)(H2O)((15)NH3)2}(1+)
  参考文献：
  名称：

  Boreham, Christopher J.; Broomhead, John A.; Fairlie, David P., Australian Journal of Chemistry, 1981, vol. 34, # 3, p. 659 - 664

  摘要：

  DOI：

文献信息

• Formation of Carbonato and Hydroxo Complexes in the Reaction of Platinum Anticancer Drugs with Carbonate
  作者：Anthony J. Di Pasqua、Corey R. Centerwall、Deborah J. Kerwood、James C. Dabrowiak

  DOI：10.1021/ic801579h

  日期：2009.2.2

  other hydroxo and carbonato species, some of which may be dinuclear complexes, are produced. Furthermore, we show that the carbonato species cis-[Pt(CO3)(OH)(NH3)2]− is also produced when cisplatin is allowed to react in carbonate buffer. The study outlines the conditions under which carboplatin and cisplatin form carbonato and aqua/hydroxo species in carbonate media.

  第二代PT II抗癌药卡铂与血液，间质液，细胞溶质和培养基中存在的碳酸盐反应，生成铂-碳酸盐和-羟基化合物。使用[ 1 H- 15 N] HSQC NMR和15 N标记的卡铂，我们观察到顺式-[PT（CBDCA- O）（OH）（NH 3）2 ] -，顺式-[PT（OH）2（NH 3）2 ]，顺式-[PT（CO 3）（OH）（NH 3）2 ] -，什么可以是顺式- [PT（CO 3）（NH 3）2 ]时产生1被允许在23.8 mM至反应碳酸盐缓冲液。当15 N标记的卡铂在0.5 M碳酸盐缓冲液中反应时，会生成这些铂族以及其他羟基和碳酸盐类，其中一些可能是双核配合物。此外，我们显示了碳酸根物种的顺式-[PT（CO 3）（OH）（NH 3）2 ] -当顺铂在碳酸盐缓冲液中反应时，也会产生氯。该研究概述了在碳酸盐介质中卡铂和顺铂形成碳酸根和水/羟基物种的条件。
• ESMS and NMR investigations on the interaction of the anticancer drug cisplatin and chemopreventive agent selenomethionine †
  作者：Qin Liu、Junyong Zhang、Xiaokang Ke、Yuhua Mei、Longgen Zhu、Zijian Guo

  DOI：10.1039/b008611h

  日期：——

  The reactions of L-selenomethionine (L-Se-MetH) with cisplatin, cis-[PtCl2(NH3)2], were investigated using electrospray mass spectroscopy (ESMS) and 2-D [1H–15N] NMR spectroscopy. The reaction intermediates and products identified were cis-[PtCl(L-Se-MetH)(NH3)2]+, cis-[Pt(L-Se-Met)(NH3)2]+, [PtCl(L-Se-MetH)(NH3)]+ and [Pt(L-Se-Met)(L-Se-MetH)]+. Some binuclear adducts were also detected by ESMS during the reaction, although they existed in minor amounts. Similar reactions with L-MetH were also conducted under similar conditions for comparison. This work provides the first detailed studies on the reaction of a platinum-based drug with L-Se-MetH.

  研究了L-硒代蛋氨酸（L-Se-MetH）与顺铂（cis-[PtCl2(NH3)2]）的反应，采用了电喷雾质谱（ESMS）和二维[1H–15N] NMR光谱。识别出的反应中间体和产物包括cis-[PtCl(L-Se-MetH)(NH3)2]+、cis-[Pt(L-Se-Met)(NH3)2]+、[PtCl(L-Se-MetH)(NH3)]+和[Pt(L-Se-Met)(L-Se-MetH)]+。在反应过程中，还通过ESMS检测到一些双核加合物，尽管它们的存在量较小。为了比较，也在类似条件下对L-MetH进行了类似反应。本研究提供了关于铂类药物与L-Se-MetH反应的首次详细研究。
• Molecular Architecture of Nanocapsules, Bilayer-Enclosed Solid Particles of Cisplatin
  作者：Vladimir Chupin、Anton I. P. M. de Kroon、Ben de Kruijff

  DOI：10.1021/ja0468933

  日期：2004.10.1

  Cisplatin nanocapsules represent a lipid formulation of the anticancer drug cis-diamminedichlo-roplatinum(II) (cisplatin) characterized by an unprecedented cisplatin-to-lipid ratio and exhibiting strongly improved cytotoxicity against tumor cells in vitro as compared to the free drug (Burger, K. N. J., et al. Nat. Med. 2002, 8, 81-84). Cisplatin nanocapsules are prepared by the repeated freezing and thawing of an equimolar dispersion of phosphatidylserine (PS) and phosphatidylcholine (PC) in a concentrated aqueous solution of cisplatin. Here, the molecular architecture of these novel nanostructures was elucidated by solid-state NMR techniques. N-15 NMR and H-2 NMR spectra of nanocapsules containing N-15- and H-2-labeled cisplatin, respectively, demonstrated that the core of the nanocapsules consists of solid cisplatin devoid of free water. Magic-angle spinning N-15 NMR showed that similar to90% of the cisplatin in the core is present as the dichloro species. The remaining 10% was accounted for by a newly discovered dinuclear Pt compound that was identified as the positively charged chloride-bridged dimer of cisplatin. NMR techniques sensitive to lipid organization, P-31 NMR and H-2 NMR, revealed that the cisplatin core is coated by phospholipids in a bilayer configuration and that the interaction between solid core and bilayer coat exerts a strong ordering effect on the phospholipid molecules. Compared to phospholipids in liposomal membranes, the motion of the phospholipid headgroups is restricted and the ordering of the acyl chains is increased, particularly in PS. The implications of these findings for the structural organization, the mechanism of formation, and the mode of action of cisplatin nanocapsules are discussed.