6-phenyl-6,7-dihydro-thieno[3,2-d]pyrimidine-2,4-diol | 157414-89-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并嘧啶酮衍生物
• 英文名称: 6-phenyl-6,7-dihydro-thieno[3,2-d]pyrimidine-2,4-diol
• 英文别名: 6-Phenyl-6,7-dihydrothieno[3,2-d]pyrimidine-2,4-diol；6-phenyl-6,7-dihydro-1H-thieno[3,2-d]pyrimidine-2,4-dione
• CAS: 157414-89-6
• 化学式: C₁₂H₁₀N₂O₂S
• 分子量: 246.29
• InChiKey: BTLHGUFEUSTGAN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  83.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-phenyl-6,7-dihydro-thieno[3,2-d]pyrimidine-2,4-diol 在 硫酸氢铵 、 氨 、 四氯化锡 作用下， 反应 21.0h， 生成 1H,3H-1-<(benzyloxy)methyl>-6-phenyl-6,7-dihydrothieno<3,2-d>pyrimidine-2,4-dione
  参考文献：
  名称：

  Synthesis and Antiviral Study of Dihydrothieno and Thianopyrimidine Diones Acyclic Nucleosides As Potential Anti-HIV Agents

  摘要：

  Acyclic nucleosides were prepared by alkylation of dihydrothieno and thianopyrimidines diones following Vorbruggen and Niedballa's method.((1))None of these HEPT analogues showed significant activity against Human Immunodeficiency Virus-1 (HIV-1).

  DOI：

  10.1080/15257779408011884
• 作为产物：
  描述：

  5-phenyl-3-ureido-4,5-dihydro-thiophene-2-carboxylic acid methyl ester 在 水 、 sodium hydroxide 、 盐酸 作用下， 以 水 为溶剂， 以89%的产率得到6-phenyl-6,7-dihydro-thieno[3,2-d]pyrimidine-2,4-diol
  参考文献：
  名称：

  [EN] SYNTHESIS OF DIHYDROTHIENO[3,2-d]PYRIMIDINE DIOLS AND SIMILAR PYRIMIDINE DIOLS
  [FR] SYNTHÈSE DE DIOLS DIHYDROTHIÉNO[3,2-d]PYRIMIDINIQUES ET DE DIOLS PYRIMIDINIQUES ANALOGUES

  摘要：

  公开号：

  WO2009140127A3

文献信息

• SYNTHESIS OF DIHYDROTHIENO[3,2-d]PYRIMIDINE DIOLS AND SIMILAR PYRIMIDINE DIOLS
  申请人：Boehringer Ingelheim International GmbH

  公开号：EP2315755A2

  公开（公告）日：2011-05-04
• SYNTHESIS IF DIHYDROTHIENO[3,2-D]PYRIMIDINE DIOLS
  申请人：Frutos Rogelio Perez

  公开号：US20110130563A1

  公开（公告）日：2011-06-02

  The present invention relates to an improved process for the preparation of dihydrothieno[3,2-d]pyrimidine diols, and similar pyrimidine diols, that is efficient, high-yielding, and does not require expensive and potentially unstable intermediates. The diols are used as intermediates in the synthesis of pyrimidine compounds which inhibit PDE4, and are thus useful in the treatment of respiratory or gastrointestinal diseases and complaints, peripheral or central nervous system diseases and disorders, inflammatory conditions, and cancers.
• US8471010B2
  申请人：——

  公开号：US8471010B2

  公开（公告）日：2013-06-25
• Synthesis and Antiviral Study of Dihydrothieno and Thianopyrimidine Diones Acyclic Nucleosides As Potential Anti-HIV Agents
  作者：Jacques Renault、Daniel Laduree、Max Robba

  DOI：10.1080/15257779408011884

  日期：1994.6

  Acyclic nucleosides were prepared by alkylation of dihydrothieno and thianopyrimidines diones following Vorbruggen and Niedballa's method.((1))None of these HEPT analogues showed significant activity against Human Immunodeficiency Virus-1 (HIV-1).
• [EN] SYNTHESIS OF DIHYDROTHIENO[3,2-d]PYRIMIDINE DIOLS AND SIMILAR PYRIMIDINE DIOLS<br/>[FR] SYNTHÈSE DE DIOLS DIHYDROTHIÉNO[3,2-d]PYRIMIDINIQUES ET DE DIOLS PYRIMIDINIQUES ANALOGUES
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2009140127A3

  公开（公告）日：2010-01-28