phosphoric acid ethyl ester-butyl ester-propyl ester | 114945-32-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: phosphoric acid ethyl ester-butyl ester-propyl ester
• 英文别名: Phosphorsaeure-aethylester-butylester-propylester；Phosphorsaeure-aethyl-butyl-propyl-ester；Butyl ethyl propyl phosphate
• CAS: 114945-32-3
• 化学式: C₉H₂₁O₄P
• 分子量: 224.237
• InChiKey: VOSBUBHATVNQIK-UHFFFAOYSA-N

物化性质

• 沸点：
  253.7±8.0 °C(Predicted)
• 密度：
  1.017±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  14
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  正溴丁烷 、 alkaline earth salt of/the/ methylsulfuric acid 在 乙醇 作用下， 生成 phosphoric acid ethyl ester-butyl ester-propyl ester
  参考文献：
  名称：

  Cheymol et al., Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1959, vol. 249, p. 2573

  摘要：

  DOI：

文献信息

• Synthesis of Mixed Alkylphosphites and Alkylphosphates
  作者：Gheorghe Ilia、Adriana Popa、Smaranda Iliescu、Alina Bora、Gheorghe Dehelean、Aurelia Pascariu

  DOI：10.1080/10426500307865

  日期：2003.7

  Some mixed phosphites having two different alkyl chain were obtained as forerunners for mixed phosphates Mixed dialkyl phosphates were obtained in good yields (40-80%) by phase transfer catalysis in liquid-liquid sistem, starting from different dialkyl phosphites and aliphatic alcohols. The reaction conditions were optimized in order to obtain good yields in phosphites and phosphates respectively.

  获得了一些具有两种不同烷基链的混合亚磷酸酯，作为混合磷酸酯的先导。从不同的亚磷酸二烷基酯和脂肪醇开始，在液-液系统中通过相转移催化以良好的收率（40-80%）获得了混合磷酸二烷基酯。优化反应条件以分别获得亚磷酸盐和磷酸盐的良好收率。通过IR、P 31 -NMR分析化合物。
• Composite membrane and method for making the same
  申请人：——

  公开号：US20010050252A1

  公开（公告）日：2001-12-13

  A composite membrane and method for making the same, comprising a porous support and a polyamide surface. The subject membrane provides improved flux and/or rejection rates. The subject membrane is further capable of operating at lower operating pressures. The subject method includes reacting a polyfunctional amine with a polyfunctional acyl halide to form a polyamide. The method includes the step of contacting a complexing agent with the polyfunctional acyl halide prior substantial reaction between the polyfunctional acyl halide and a polyfunctional amine. The subject process is easily adapted to commercial scale manufacturing processes and is particularly suited for making nanofiltration and reverse osmosis composite membranes.

  一种复合膜及其制造方法，包括多孔支架和聚酰胺表面。该膜提高了通量和/或排斥率。该膜还能在较低的工作压力下工作。该方法包括将多官能团胺与多官能团酰基卤反应生成聚酰胺。该方法包括在多官能酰基卤与多官能胺发生实质性反应之前，将络合剂与多官能酰基卤接触。该主题工艺很容易适用于商业规模的制造工艺，尤其适用于制造纳滤和反渗透复合膜。
• COMPOSITE MEMBRANE AND METHOD FOR MAKING THE SAME
  申请人：DOW GLOBAL TECHNOLOGIES INC.

  公开号：EP1276551A2

  公开（公告）日：2003-01-22
• Prodrugs of NH-Acidic Compounds
  申请人：Alkermes Pharma Ireland Limited

  公开号：US20150376143A1

  公开（公告）日：2015-12-31

  The invention provides a method of sustained delivery of a lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug by administering to a patient an effective amount of a prodrug compound of the invention wherein upon administration to the patient, release of the parent drug from the prodrug is sustained release. Prodrug compounds suitable for use in the methods of the invention are labile conjugates of parent drugs that are derivatized through carbonyl linked prodrug moieties. The prodrug compounds of the invention can be used to treat any condition for which the lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug is useful as a treatment.
• US6337018B1
  申请人：——

  公开号：US6337018B1

  公开（公告）日：2002-01-08