butyryl-phosphoric acid diethyl ester | 118019-51-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: butyryl-phosphoric acid diethyl ester
• 英文别名: Butyryl-phosphorsaeure-diaethylester；ethyl (diethoxyphosphinyl) acetate；ethyl diethylphosphono acetate；O-Butyryl-O,O-diethylphosphat；Diethoxyphosphoryl butanoate
• CAS: 118019-51-5
• 化学式: C₈H₁₇O₅P
• 分子量: 224.194
• InChiKey: VLXHBSIVQJISIW-UHFFFAOYSA-N

物化性质

• 沸点：
  79 °C(Press: 0.05 Torr)
• 密度：
  1.115±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  14
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-甲基-4-氧代哌啶-1-羧酸甲酯 、 butyryl-phosphoric acid diethyl ester 以 乙二醇二甲醚 为溶剂， 以56.9 parts (78.6%)的产率得到methyl-4-(2-ethoxy-2-oxoethylidene)-3-methyl-1-piperidinecarboxylate
  参考文献：
  名称：

  Novel pyridazinamine derivatives

  摘要：

  具有抗病毒活性的新型吡啶唑胺衍生物，含有这些化合物的组合物以及用所述化合物破坏或防止病毒生长的方法，用于治疗由这些病毒引起的疾病的温血动物。以及制备所述化合物和组合物的方法。

  公开号：

  US04992433A1
• 作为产物：
  描述：

  3-ethoxy-3-diethoxyphosphoryloxy-acrylic acid ethyl ester 、 丁酸 生成 butyryl-phosphoric acid diethyl ester
  参考文献：
  名称：

  Cramer; Gaertner, Chemische Berichte, 1958, vol. 91, p. 704,711,712

  摘要：

  DOI：

文献信息

• [EN] A NOVEL PROCESS FOR MAKING ALISKIREN, ITS NOVEL INTERMEDIATES AND CERTAIN NOVEL COMPOUNDS<br/>[FR] NOUVEAU PROCÉDÉ DE PRODUCTION D'ALISKIRÈNE, SES NOUVEAUX INTERMÉDIAIRES ET CERTAINS NOUVEAUX COMPOSÉS
  申请人：AVRA LAB PVT LTD

  公开号：WO2011064790A1

  公开（公告）日：2011-06-03

  A novel process for making Renin inhibitors like Aliskiren is disclosed. Its novel intermediate compounds and method of making them are also disclosed.

  揭示了一种制备类似阿利斯基仑的肾素抑制剂的新型工艺。同时还披露了其新型中间体化合物和制备方法。
• N-acylamino acid derivatives and their pharmaceutical compositions
  申请人：Banyu Pharmaceutical Co., Ltd.

  公开号：US05122523A1

  公开（公告）日：1992-06-16

  An N-acylamino acid derivative of the formula: ##STR1## wherein the substituents are herein defined or a salt thereof, which is useful as hypotensive drugs.

  一种公式为：##STR1## 的N-酰氨基酸衍生物，其中取代基如此定义或其盐，可用作降压药物。
• Receptor Function Regulator
  申请人：Fukatsu Kohji

  公开号：US20090012093A1

  公开（公告）日：2009-01-08

  The GPR40 receptor function regulator of the present invention, which comprises a compound having an aromatic ring and a group capable of releasing cation is useful as an insulin secretagogue or an agent for the prophylaxis or treatment of diabetes and the like.

  本发明的GPR40受体功能调节剂包括具有芳香环和能够释放阳离子的基团的化合物，可用作胰岛素分泌剂或预防或治疗糖尿病等疾病的药剂。
• 5-Substituted amino-4-hydroxy-pentanoic acid derivatives and their use
  申请人：Banyu Pharmaceutical Co., Ltd.

  公开号：EP0264106A2

  公开（公告）日：1988-04-20

  A 5-substituted amino-4-hydroxy-pentanoic acid derivative having the formula: wherein R¹ is a hydrogen atom, a lower alkoxycarbonyl group, an aryloxycarbonyl group, an aralkyloxycarbonyl group or a lower alkanoyl group which may be substituted by from one to three substituents selected from the group consisting of an amino group, a hydroxyl group, a carboxyl group, an aryloxy group, an aralkyloxycarbonylamino group, a lower alkoxycarbonylamino group wherein each of X¹ and X² which may be the same or different is a hydrogen atom, a lower alkyl group, an aryl group or an aralkyl group, or X¹ and X² form together with the adjacent nitrogen atom a 5- or 6-membered heterocyclic group which may further contain a hereto atom selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom which may further contain a double bond in its carbon chain, each of R², R³ and R⁵ which may be the same or different is a hydrogen atom, a lower alkyl group or a residue of an acidic, neutral or basic amino acid, R⁴ is a hydrogen atom or a lower alkyl group, R⁶ is a lower alkyl, cycloalkyl, cycloalkylalkyl or aralkyl group which is substituted by one or two hydroxyl groups, R⁷ is a hydroxyl group, a -OY group wherein Y is a lower alkyl group, an aryl group, an aralkyl group, a lower alkoxyalkyl group, a lower alkanoyloxyalkyl group, a lower alkoxycarbonyloxyalkyl group or a 1-phthalidyl group, wherein each of Y¹ and Y² which may be the same or different is a hydrogen atom, a lower alkyl group, an aryl group, an aralkyl group or a cycloalkyl group, or Y¹ and Y² form together with the adjacent nitrogen atom 5- or 5-membered heterocyclic group which may further contain a hereto atom selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom, and each of n and m which may be the same or different is 0 or 1.

  5-取代氨基-4-羟基戊酸衍生物，其式如下 其中 R¹为氢原子、低级烷氧基羰基、芳氧基羰基、芳烷氧基羰基或低级烷酰基，该低级烷酰基可被选自氨基、羟基、羧基、芳氧基、芳烷氧基羰基氨基、低级烷氧基羰基氨基所组成的组中的一至三个取代基所取代 其中 X¹ 和 X² 可相同或不同，各自为氢原子、低级烷基、芳基或芳烷基，或 X¹ 和 X² 与邻近的氮原子一起形成 5 或 6 元杂环基团，该杂环基团可进一步包含一个从氮原子、氧原子和硫原子组成的组中选出的同族原子，该杂环基团可进一步在其碳链中包含一个双键，R²、R³ 和 R⁵ 可相同或不同，各自为氢原子、R⁴ 是氢原子或低级烷基，R⁶ 是被一个或两个羟基取代的低级烷基、环烷基、环烷基烷基或芳烷基、R⁷ 是羟基、-OY 基团，其中 Y 是低级烷基、芳基、芳烷基、低级烷氧基烷基、低级烷酰氧基烷基、低级烷氧羰氧基烷基或 1-邻苯二甲酰基、 其中Y¹和Y²可以相同或不同，各自为氢原子、低级烷基、芳基、芳烷基或环烷基，或Y¹和Y²与相邻的氮原子一起形成5元或5元杂环基团，该杂环基团可进一步包含一个从氮原子、氧原子和硫原子组成的组中选出的同位原子，且n和m可以相同或不同，各自为0或1。
• Optically active monophosphino carboxylic acid derivative
  申请人：NISSAN CHEMICAL INDUSTRIES LTD.

  公开号：EP0751141A1

  公开（公告）日：1997-01-02

  An optically active monophosphino carboxylic acid derivative of formula (I): wherein:    each R1 independently represents a C1-6 alkyl group or phenyl group which is unsubstituted or substituted with a C1-4 alkyl group or C1-4 alkoxy group;    R2 represents a C1-4 alkyl group; and    R3 and R4 each independently represents a hydrogen atom, or a C1-4 alkyl group or phenyl group which is unsubstituted or substituted with a C1-4 alkyl or C1-4 alkoxy group.

  一种具有光学活性的式 (I) 单磷羧酸衍生物： 其中 每个 R1 独立地代表未被取代或被 C1-4 烷基或 C1-4 烷氧基取代的 C1-6 烷基或苯基； R2 代表 C1-4 烷基；以及 R3 和 R4 各自独立地代表一个氢原子，或一个未被 C1-4 烷基或 C1-4 烷氧基取代或被 C1-4 烷基或 C1-4 烷氧基取代的 C1-4 烷基或苯基。