Methyl-2-chloraethyl-phosphinsaeure-2-chloraethylester | 36120-71-5

• 分子结构分类: 有机化合物 - 有机磷化合物
• 英文名称: Methyl-2-chloraethyl-phosphinsaeure-2-chloraethylester
• 英文别名: 2-Chloroethyl-methyl-2-chloromethylphosphinat；1-Chloro-2-[2-chloroethyl(methyl)phosphoryl]oxyethane
• CAS: 36120-71-5
• 化学式: C₅H₁₁Cl₂O₂P
• 分子量: 205.021
• InChiKey: OLUPRCPCOSGXIW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Methyl-2-chloraethyl-phosphinsaeure-2-chloraethylester 在 三乙胺 作用下， 生成 methyl-vinyl-phosphinic acid 2-chloro-ethyl ester
  参考文献：
  名称：

  Weissermel; Kleiner; Finke, Angewandte Chemie, 1981, vol. 93, # 3, p. 256 - 265

  摘要：

  DOI：
• 作为产物：
  描述：

  Methylphosphinsaeure-bis(2-chlorethylester) 生成 Methyl-2-chloraethyl-phosphinsaeure-2-chloraethylester
  参考文献：
  名称：

  Weissermel; Kleiner; Finke, Angewandte Chemie, 1981, vol. 93, # 3, p. 256 - 265

  摘要：

  DOI：

文献信息

• Process for producing alkyl 4-(alkoxy methyl phosphinoyl)butyrates and alkyl-(2-amino-4-(alkoxy methyl phosphinoyl)) butyrates
  申请人：MEIJI SEIKA KAISHA LTD.

  公开号：EP0018415A1

  公开（公告）日：1980-11-12

  Dialkyl 4-methylphosphinobutyrates represented by the following general formula; (wherein R, represents hydrogen atom or acylamino group, and R2 and Rs each represents C1-C5 alkyl group) are intermediates for D,L-2-amino-4-methylphosphinobutyric acid useful as a herbicide, and are prepared by reacting a corresponding vinylacetic acid ester with methylphosphorous acid monoalkyl ester at 100-200"C in the presence of a radical-generating agent or under irradiation with ultraviolet rays.

  由以下通式表示的 4-甲基膦酰基丁酸二烷基酯 (其中 R 代表氢原子或酰基氨基，R2 和 Rs 各代表 C1-C5 烷基）是用作除草剂的 D,L-2-氨基-4-甲基膦丁酸的中间体，其制备方法是在自由基生成剂存在下或在紫外线照射下，使相应的乙烯基乙酸酯与甲基磷酸单烷基酯在 100-200 "C 下反应。
• Gross; Gnauk Th., Journal fur praktische Chemie (Leipzig 1954), 1976, vol. 318, # 1, p. 157 - 160
  作者：Gross、Gnauk Th.

  DOI：——

  日期：——
• Inhibition of the Antibacterial Target UDP-(3-<i>O</i>-acyl)-<i>N</i>-acetylglucosamine Deacetylase (LpxC):  Isoxazoline Zinc Amidase Inhibitors Bearing Diverse Metal Binding Groups
  作者：Michael C. Pirrung、L. Nathan Tumey、Christian R. H. Raetz、Jane E. Jackman、Karnem Snehalatha、Amanda L. McClerren、Carol A. Fierke、Stephanie L. Gantt、Kristin M. Rusche

  DOI：10.1021/jm020183v

  日期：2002.9.1

  UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase (LpxC) is a zinc amidase that catalyzes the second step of lipid A biosynthesis in Gram negative bacteria. Known inhibitors of this enzyme are oxazolines incorporating a hydroxamic acid at the 4-position, which is believed to coordinate to the single essential zinc ion. A new structural class of inhibitors was designed to incorporate a more stable and more synthetically. versatile isoxazoline core. The synthetic versatility of the isoxazoline allowed for a broad study of metal binding. groups. Nine of 17 isoxazolines, each incorporating a different potential metal binding functional group, were found to exhibit enzyme inhibitory activity, including one that is more active than the corresponding hydroxamic acid. Additionally, a designed affinity label inhibits LpxC in a time-dependent manner.
• TAKIGAVA, SINITIRO;NIIKEH, SYUDZO
  作者：TAKIGAVA, SINITIRO、NIIKEH, SYUDZO

  DOI：——

  日期：——
• TANAKA, MASATO;SAKAKURA, TOSIYASU;TAKIGAVA, SINITIRO;ARAYA, SYUDZO
  作者：TANAKA, MASATO、SAKAKURA, TOSIYASU、TAKIGAVA, SINITIRO、ARAYA, SYUDZO

  DOI：——

  日期：——