1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[[di(propan-2-yl)amino]-hex-5-ynoxyphosphanyl]oxyoxolan-2-yl]-5-methylpyrimidine-2,4-dione | 1352942-20-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[[di(propan-2-yl)amino]-hex-5-ynoxyphosphanyl]oxyoxolan-2-yl]-5-methylpyrimidine-2,4-dione
• CAS: 1352942-20-1
• 化学式: C₄₃H₅₄N₃O₈P
• 分子量: 771.891
• InChiKey: HEBNQDJTPKTKFU-YWTNWLAESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.3
• 重原子数：
  55
• 可旋转键数：
  19
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  108
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  、 保护胸苷 在 4-二甲氨基吡啶 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以222 mg的产率得到1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[[di(propan-2-yl)amino]-hex-5-ynoxyphosphanyl]oxyoxolan-2-yl]-5-methylpyrimidine-2,4-dione
  参考文献：
  名称：

  Reversible modification of oligodeoxynucleotides: click reaction at phosphate group and alkali treatment

  摘要：

  We characterized click reaction between oligodeoxynucleotides (ODNs) possessing acetylene groups at the phosphate unit and azide compounds. Cu(I)-catalyzed cycloaddition proceeded efficiently to form the corresponding functional ODNs. The resulting ODNs could be converted into ordinary ODNs by treatment with aqueous methylamine. The present method successfully achieved a reversible modification of ODNs. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.10.109

文献信息

• Reversible modification of oligodeoxynucleotides: click reaction at phosphate group and alkali treatment
  作者：Kazuhito Tanabe、Yuichirou Ando、Sei-ichi Nishimoto

  DOI：10.1016/j.tetlet.2011.10.109

  日期：2011.12

  We characterized click reaction between oligodeoxynucleotides (ODNs) possessing acetylene groups at the phosphate unit and azide compounds. Cu(I)-catalyzed cycloaddition proceeded efficiently to form the corresponding functional ODNs. The resulting ODNs could be converted into ordinary ODNs by treatment with aqueous methylamine. The present method successfully achieved a reversible modification of ODNs. (C) 2011 Elsevier Ltd. All rights reserved.