sphingosine-1-phosphate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: sphingosine-1-phosphate
• 英文别名: S1P；C16 Sphingosine-1-phosphate；[(E,2S,3R)-2-amino-3-hydroxyhexadec-4-enyl] dihydrogen phosphate
• 化学式: C₁₆H₃₄NO₅P
• 分子量: 351.423
• InChiKey: IQHNJQKWEMCXAD-YYZTVXDQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  23
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  113
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  C16-鞘氨醇 在 吡啶 、 sodium hydroxide 、 三甲基溴硅烷 、 四溴化碳 作用下， 以 1,4-二氧六环 、 二氯甲烷 为溶剂， 生成 sphingosine-1-phosphate
  参考文献：
  名称：

  Syntheses of sphingosine-1-phosphate analogues and their interaction with EDG/S1P receptors

  摘要：

  Sphingosine-I-phosphate (SIP) is an important regulator of a wide variety of biological processes acting as an endogenous ligand to EDG/S1P receptors. In an effort to establish structure-activity relationship between EDG/S1P and ligands, we report herein homology modeling study of EDG-1/S1P(1), syntheses of S I P analogues, and cell based binding affinity study for EDG/S1P receptors. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.03.001

文献信息

• ARTIFICIALLY SYNTHESIZED SPHINGOSINE DERIVATIVE LIPOID MONOMER AND USE OF SAME FOR DELIVERING NUCLEIC ACID
  申请人：INSTITUTE OF BASIC MEDICAL SCIENCES CHINESE ACADEMY OF MEDICAL SCIENCES

  公开号：US20210015767A1

  公开（公告）日：2021-01-21

  The invention provides an artificially synthesized single sphingosine lipid and use of delivering a nucleic acid thereof. More particularly, the invention provides Use or method for delivering a nucleic acid to a cell or a subject using a compound of Formula (I), a stereoisomer or a pharmaceutical acceptable salt thereof, or a combination comprising a compound of Formula (I), a stereoisomer or a pharmaceutical acceptable salt thereof,
• Syntheses of sphingosine-1-phosphate analogues and their interaction with EDG/S1P receptors
  作者：Hyun-Suk Lim、Jeong-Ju Park、Kwangseok Ko、Mee-Hyun Lee、Sung-Kee Chung

  DOI：10.1016/j.bmcl.2004.03.001

  日期：2004.5

  Sphingosine-I-phosphate (SIP) is an important regulator of a wide variety of biological processes acting as an endogenous ligand to EDG/S1P receptors. In an effort to establish structure-activity relationship between EDG/S1P and ligands, we report herein homology modeling study of EDG-1/S1P(1), syntheses of S I P analogues, and cell based binding affinity study for EDG/S1P receptors. (C) 2004 Elsevier Ltd. All rights reserved.