phenyl 2,3-dihydroxybenzoate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 缩酚酸和缩酚酸环醚类
• 英文名称: phenyl 2,3-dihydroxybenzoate
• 化学式: C₁₃H₁₀O₄
• 分子量: 230.22
• InChiKey: AQTQYIUNVPGYNL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  苯甲酸,二羟基- 、 苯酚 在 N,N'-二环己基碳二亚胺 、 4-二甲氨基吡啶 作用下， 以 乙腈 为溶剂， 反应 4.0h， 以49%的产率得到phenyl 2,3-dihydroxybenzoate
  参考文献：
  名称：

  Structural optimization and neurotrophic activity evaluation of neurotrophic gentiside derivatives

  摘要：

  C14 alkyl benzoate ABG001, derived from naturally occurring gentisides, was reported to exhibit neurotrophic activity which is similar to NGF (Nerve Growth Factor). In this research, ABG001 was modified by the strategy of isosteric replacement and conformational restriction with the purpose of improving the bioactivity. The cellular neurotrophic activity of those ABG001 derivatives were evaluated, among which 3-hydroxyquinolin-2-(1H)-one A3 and 4-decylphenol ester B7 displayed much better neurotrophic activity compared with ABG001, which highlights the potential of those novel scaffolds for future neurotrophic agent development.

  DOI：

  10.1016/j.bmcl.2019.126685

文献信息

• PROCESS FOR PRODUCING AROMATIC CARBONATE
  申请人：Asahi Kasei Chemicals Corporation

  公开号：EP1829854A1

  公开（公告）日：2007-09-05

  Production of an aromatic carbonic ester through an ester exchange reaction between a starting material and a reactant while distilling by-product alcohols and/or by-product dialkyl carbonates off the reaction system, wherein use is made of a specified catalyst.

  通过起始原料和反应物之间的酯交换反应生产芳香族碳酸酯，同时从反应体系中蒸馏出副产物醇和/或副产物二烷基碳酸酯，其中使用特定的催化剂。
• PROCESS FOR THE PREPARATION OF AROMATIC CARBONATES
  申请人：Asahi Kasei Kabushiki Kaisha

  公开号：EP1016648B1

  公开（公告）日：2003-05-14
• Process for Producing Aromatic Carbonate
  申请人：Miyake Nobuhisa

  公开号：US20080177099A1

  公开（公告）日：2008-07-24

  Production of an aromatic carbonic ester through an ester exchange reaction between a starting material and a reactant while distilling by-product alcohols and/or by-product dialkyl carbonates off the reaction system, wherein use is made of a specified catalyst.
• US4394389A
  申请人：——

  公开号：US4394389A

  公开（公告）日：1983-07-19
• US4448730A
  申请人：——

  公开号：US4448730A

  公开（公告）日：1984-05-15