This invention provides thiomorpholinone compounds useful for treating multiple sclerosis of formula I wherein: R.sup.1 and R.sup.2 are each independently selected from C.sub.1 -C.sub.8 alkyl; C.sub.2 -C.sub.8 alkenyl; C.sub.2 -C.sub.8 alkynyl; C.sub.1 -C.sub.8 alkyloxy; C.sub.1 -C.sub.8 alkylthio; trifluoromethyl; C.sub.1 -C.sub.4 alkyl substituted with phenyl; phenyl; F; Cl; NO.sub.2 ; phenoxy; C.sub.1 -C.sub.4 alkyl substituted with phenoxy; thiophenyl; C.sub.1 -C.sub.4 alkylthiophenyl; --COOR.sup.7 ; --N(R.sup.7).sub.2 or --N(R.sup.7)SO.sub.2 R.sup.7 where each R.sup.7 is independently hydrogen or C.sub.1 -C.sub.6 alkyl; R.sup.3 is H or C.sub.1 -C.sub.4 alkyl; R.sup.4 and R.sup.5 are each individually H, or when taken together form a bond; R.sup.6 is H; C.sub.1 -C.sub.8 alkyl; C.sub.2 -C.sub.8 alkenyl; C.sub.2 -C.sub.8 alkynyl; --SO.sub.2 CH.sub.3 ; --(CH.sub.2).sub.n NR.sup.8 R.sup.9 ; --(CH.sub.2).sub.n CO.sub.2 R.sup.8 ; --(CH.sub.2).sub.n OR.sup.8 where n is an integer from 1 to 6, both inclusive, and R.sup.8 and R.sup.9 are each independently hydrogen; C.sub.1 -C.sub.6 alkyl; C.sub.2 -C.sub.6 alkenyl; C.sub.2 -C.sub.6 alkynyl; phenyl; C.sub.1 -C.sub.4 alkyl substituted with phenyl; --(CH.sub.2).sub.q OH; or (CH.sub.2).sub.q S(C.sub.1 -C.sub.4 alkyl) where q is an integer from 2 to 6, both inclusive; and ##STR1## where m is 0 or 1; or a pharmaceutically acceptable salt or optical isomer thereof.
该发明提供了用于治疗多发性硬化症的噻吗啉酮化合物,其
化学式为I,其中:R.sup.1和R.sup.2各自独立地选自C.sub.1-C.sub.8烷基;C.sub.2-C.sub.8烯基;C.sub.2-C.sub.8炔基;C.sub.1-C.sub.8烷氧基;C.sub.1-C.sub.8烷
硫基;三
氟甲基;C.sub.1-C.sub.4烷基取代的苯基;苯基;F;Cl;NO.sub.2;苯氧基;C.sub.1-C.sub.4烷基取代的苯氧基;
噻吩基;C.sub.1-C.sub.4烷基
噻吩基;--COOR.sup.7;--N(R.sup.7).sub.2或--N(R.sup.7)SO.sub.2R.sup.7,其中每个R.sup.7独立地为氢或C.sub.1-C.sub.6烷基;R.sup.3为H或C.sub.1-C.sub.4烷基;R.sup.4和R.sup.5各自独立地为H,或当它们在一起时形成键;R.sup.6为H;C.sub.1-C.sub.8烷基;C.sub.2-C.sub.8烯基;C.sub.2-C.sub.8炔基;--SO.sub.2CH.sub.3;--(CH.sub.2).sub.nNR.sup.8R.sup.9;--(CH.sub.2).sub.nCO.sub.2R.sup.8;--(CH.sub.2).sub.nOR.sup.8,其中n为1至6之间的整数,包括1和6,R.sup.8和R.sup.9各自独立地为氢;C.sub.1-C.sub.6烷基;C.sub.2-C.sub.6烯基;C.sub.2-C.sub.6炔基;苯基;C.sub.1-C.sub.4烷基取代的苯基;--(CH.sub.2).sub.qOH;或(CH.sub.2).sub.qS(C.sub.1-C.sub.4烷基),其中q为2至6之间的整数,包括2和6;以及##STR1## 其中m为0或1;或其药学上可接受的盐或其光学异构体。