dibutyl 3-phenylpropyl phosphate | 144357-50-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: dibutyl 3-phenylpropyl phosphate
• CAS: 144357-50-6
• 化学式: C₁₇H₂₉O₄P
• 分子量: 328.389
• InChiKey: FGEMIDAJSRONKA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  22
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-溴-3-苯基丙烷 、 磷酸二丁酯 在 caesium carbonate 作用下， 以 乙腈 为溶剂， 反应 12.0h， 以90%的产率得到dibutyl 3-phenylpropyl phosphate
  参考文献：
  名称：

  Base-promoted O-deprotonation/alkylation reaction of P(O)–OH compounds with alkyl halides

  摘要：

  A novel base-promoted O-deprotonation/alkylation reaction of P(O)-OH compounds with alkyl halides has been developed. The protocol is practical, representing a simple way to produce a broad spectrum of functionalized phosphinates, phosphonates, and phosphates from basic starting materials with good to excellent yields. A plausible mechanism was proposed for this reaction. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.10.013

文献信息

• Some Properties of Cyclic Phosphoramidites and Their Phosphites: Phosphitylation, Ester Exchange, and Hydrolysis
  作者：Yutaka Watanabe、Shin-ichi Maehara

  DOI：10.3987/com-99-s89

  日期：——

  Phosphorylation of diols using sterically bulky cyclic phosphoramidites was performed in a good selectivity. Their phosphite derivatives underwent tetrazole-catalyzed hydrolysis and transesterification. The reaction was shown to proceed via a phosphorane intermediate by MMR analysis.
• Watanabe, Yutaka; Maehara, Shin-ichi; Ozaki, Shoichiro, Journal of the Chemical Society. Perkin transactions I, 1992, # 15, p. 1879 - 1880
  作者：Watanabe, Yutaka、Maehara, Shin-ichi、Ozaki, Shoichiro

  DOI：——

  日期：——