carboxymethyl di-tert-butyl phosphate | 130985-37-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: carboxymethyl di-tert-butyl phosphate
• 英文别名: [(di-tert-butoxyphosphoryl)oxy]acetic acid；2-((di-tert-butoxyphosphoryl)oxy)acetic acid；glycolic acid-O-(di-tert-butyl)phosphate；(Di-tert-butoxy-phosphoryloxy)-acetic acid；2-[bis[(2-methylpropan-2-yl)oxy]phosphoryloxy]acetic acid
• CAS: 130985-37-4
• 化学式: C₁₀H₂₁O₆P
• 分子量: 268.247
• InChiKey: OBNORMCGWHFKGY-UHFFFAOYSA-N

物化性质

• 沸点：
  342.8±25.0 °C(Predicted)
• 密度：
  1.158±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  82.1
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  carboxymethyl di-tert-butyl phosphate 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以91%的产率得到(膦酰氧基)乙酸
  参考文献：
  名称：

  Nanoscale Ionic Diodes with Tunable and Switchable Rectifying Behavior

  摘要：

  Nanoscale ionic diodes have attracted interest as circuit elements for development of nanofluidic devices for a variety of applications. including biosensing, constructing artificial cells, and engineering biological batteries. This paper presents a bottom-up. Self-assembly approach for constructing nanopores with rectified conductance behavior in a membrane using semisynthetic derivatives of the ion-channel-forming peptide gramicidin A. The capability to individually access each half of a dimeric gramicidin channel makes it possible to generate asymmetric channels ill a membrane that exhibit diodelike conductance properties. The modular nature of these self-assembled channels affords the possibility of tuning their rectifying conductance properties by simple replacement of one peptide derivative with another in the membrane. Additionally, introduction of an external stimulus there, an enzyme) to change the Functional group attached to one side of the gramicidin pore induces diodelike conductance behavior in previously nonrectified channels, demonstrating the possibility of switching the conductance properties of these nanopores in situ in a controlled manner.

  DOI：

  10.1021/ja909876h
• 作为产物：
  描述：

  N,N-二乙基亚磷酰胺二叔丁酯 在 四氮唑 、 甲醇 、 sodium hydroxide 作用下， 以 四氢呋喃 、 乙腈 为溶剂， 反应 3.67h， 生成 carboxymethyl di-tert-butyl phosphate
  参考文献：
  名称：

  [EN] PRODRUG MODULATORS OF THE INTEGRATED STRESS PATHWAY
  [FR] MODULATEURS DE PROMÉDICAMENTS DE LA VOIE DE RÉPONSE INTÉGRÉE AU STRESS

  摘要：

  本文提供了用于调节综合应激反应（ISR）并治疗相关疾病、疾病和症状的化合物、组合物和方法。

  公开号：

  WO2020077217A1

文献信息

• ANTIMICROBIAL OXAZOLIDINONE PRODRUGS
  申请人：Macielag Mark J.

  公开号：US20080027053A1

  公开（公告）日：2008-01-31

  This invention includes oxazolidinone prodrug compounds of Formula (I) and Formula (II) as defined herein. The prodrugs are convertible by natural biological processes into an active ingredient possessed of antimicrobial properties useful in treating bacterial infections in mammals.

  这项发明包括本文所定义的Formula (I)和Formula (II)的噁唑烷酮前药化合物。这些前药可以通过自然生物过程转化为一种具有抗微生物特性的活性成分，可用于治疗哺乳动物体内的细菌感染。
• Synthetic Posttranslational Modifications: Chemical Catalyst-Driven Regioselective Histone Acylation of Native Chromatin
  作者：Yoshifumi Amamoto、Yuki Aoi、Nozomu Nagashima、Hiroki Suto、Daisuke Yoshidome、Yasuhiro Arimura、Akihisa Osakabe、Daiki Kato、Hitoshi Kurumizaka、Shigehiro A. Kawashima、Kenzo Yamatsugu、Motomu Kanai

  DOI：10.1021/jacs.7b02138

  日期：2017.6.7

  antigen)-peptide, promotes both natural (including acetylation, butyrylation, malonylation, and ubiquitination) and non-natural (azido- and phosphoryl labeling) PTMs on histones in recombinant nucleosomes and/or in native chromatin, at lysine residues close to the DSH moiety. To investigate the validity of our method, we used LANA-DSH to promote histone H2B lysine-120 (K120) acylation, the function of

  组蛋白的翻译后修饰 (PTM) 在控制基因转录的复杂调控机制中起着重要作用，它们的失调会导致癌症等疾病。然而，缺乏对天然染色质进行位点选择性修饰的方法限制了我们对特定组蛋白 PTM 的功能作用的理解，不是作为单一标记，而是在相互交织的 PTM 网络中。在这里，我们报告了一种合成催化剂 DMAP-SH (DSH)，它在生理条件下激活化学稳定的硫酯（包括乙酰辅酶 A）并将各种酰基转移到邻近的氨基。我们的数据表明，与核小体配体（如吡咯-咪唑-聚酰胺和 LANA（潜伏期相关核抗原）-肽）结合的 DSH 可促进天然（包括乙酰化、丁酰化、丙二酰化、和泛素化）和非天然（叠氮基和磷酰基标记）PTM 位于重组核小体和/或天然染色质中靠近 DSH 部分的赖氨酸残基处的组蛋白上。为了研究我们方法的有效性，我们使用 LANA-DSH 来促进组蛋白 H2B 赖氨酸-120 (K120) 酰化，其功能在很大程度上是未知的。H2BK120
• Antimicrobial oxazolidinone prodrugs
  申请人：Janssen Pharmaceutica N.V.

  公开号：US07776855B2

  公开（公告）日：2010-08-17

  This invention includes oxazolidinone prodrug compounds of Formula (I) and Formula (II) as defined herein. The prodrugs are convertible by natural biological processes into an active ingredient possessed of antimicrobial properties useful in treating bacterial infections in mammals.

  本发明涉及Formula(I)和Formula(II)的噁唑烷酮前药化合物，如本文所定义。这些前药化合物可以通过自然的生物过程转化为具有抗微生物活性的活性成分，用于治疗哺乳动物的细菌感染。
• Prodrug modulators of the integrated stress pathway
  申请人：Calico Life Sciences LLC

  公开号：US11149043B2

  公开（公告）日：2021-10-19

  Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.

  本文提供了用于调节综合应激反应（ISR）和治疗相关疾病、失调和病症的化合物、组合物和方法。
• Renin inhibitory peptides. Incorporation of polar, hydrophilic end groups into an active renin inhibitory peptide template and their evaluation in a human renin-infused rat model and in conscious sodium-depleted monkeys
  作者：Suvit Thaisrivongs、Donald T. Pals、Donald W. DuCharme、Steve R. Turner、Garry L. DeGraaf、Judy A. Lawson、Sally J. Couch、Mark V. Williams

  DOI：10.1021/jm00106a026

  日期：1991.2

  We previously reported that Boc-Pro-Phe-N-MeHis-Leu-psi[CHOHCH2]?? -Ile-Amp (1) is a potent and specific inhibitor of human renin in vitro. It was shown to resist degradation by selected proteases and a rat liver homogenate. It was shown to inhibit plasma renin activity and to reduce blood pressure in renin-dependent-animal models both by the intravenous and by the oral routes using dilute citric acid as vehicle. In an effort to discover compounds with improved pharmacological efficacy, we set out to modify the physical characteristics of this highly lipophilic renin inhibitor by incorporation of hydrophilic end groups. We report here a variety of water-solubilizing groups and the resulting structure-activity relationship of these compounds. They all maintain an extremely high level of enzyme inhibitory activity in vitro. Evaluation of these potent renin inhibitors in a human renin infused rat model suggests that some of these compounds exhibit improved pharmacological efficacy in vivo. This observation was further confirmed in the conscious sodium-depleted cynomolgus monkey. Importantly, the oral efficacy was demonstrated in a water vehicle in the absence of citric acid.